Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design
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Title
Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design
Authors
Keywords
Lipids, Lipid structure, Viral structure, Antibodies, Crystal structure, Glycerol, HIV-1, Electron density
Journal
PLoS Pathogens
Volume 13, Issue 2, Pages e1006212
Publisher
Public Library of Science (PLoS)
Online
2017-02-23
DOI
10.1371/journal.ppat.1006212
References
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Note: Only part of the references are listed.- Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design
- (2016) Dennis R. Burton et al. Annual Review of Immunology
- Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10
- (2016) Adriana Irimia et al. IMMUNITY
- Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design
- (2016) Young D. Kwon et al. JOURNAL OF VIROLOGY
- Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer
- (2016) J. H. Lee et al. SCIENCE
- Structural basis for membrane anchoring of HIV-1 envelope spike
- (2016) J. Dev et al. SCIENCE
- Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8
- (2016) Cinque Soto et al. PLoS One
- The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region
- (2015) Beatriz Apellániz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure and immune recognition of trimeric pre-fusion HIV-1 Env
- (2014) Marie Pancera et al. NATURE
- Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10
- (2013) C. Doyle-Cooper et al. JOURNAL OF IMMUNOLOGY
- Common Tolerance Mechanisms, but Distinct Cross-Reactivities Associated with gp41 and Lipids, Limit Production of HIV-1 Broad Neutralizing Antibodies 2F5 and 4E10
- (2013) Y. Chen et al. JOURNAL OF IMMUNOLOGY
- Mechanism of HIV-1 Neutralization by Antibodies Targeting a Membrane-Proximal Region of gp41
- (2013) J. Chen et al. JOURNAL OF VIROLOGY
- Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
- (2013) J.-P. Julien et al. SCIENCE
- Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
- (2013) D. Lyumkis et al. SCIENCE
- Comparative lipidomics analysis of HIV-1 particles and their producer cell membrane in different cell lines
- (2012) Maier Lorizate et al. CELLULAR MICROBIOLOGY
- Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
- (2012) Jinghe Huang et al. NATURE
- Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function
- (2012) Javier Guenaga et al. PLoS Pathogens
- Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation
- (2012) Erin E. H. Tran et al. PLoS Pathogens
- Reactivity profiles of broadly neutralizing anti-HIV-1 antibodies are distinct from those of pathogenic autoantibodies
- (2011) Harvir Singh et al. AIDS
- Direct Antibody Access to the HIV-1 Membrane-Proximal External Region Positively Correlates with Neutralization Sensitivity
- (2011) B. K. Chakrabarti et al. JOURNAL OF VIROLOGY
- Binding of Anti-Membrane-Proximal gp41 Monoclonal Antibodies to CD4-Liganded and -Unliganded Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Virions
- (2011) R. Rathinakumar et al. JOURNAL OF VIROLOGY
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions
- (2010) E. M. Scherer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope
- (2010) Bruno E. Correia et al. STRUCTURE
- Molecular Architectures of Trimeric SIV and HIV-1 Envelope Glycoproteins on Intact Viruses: Strain-Dependent Variation in Quaternary Structure
- (2010) Tommi A. White et al. PLoS Pathogens
- CHARMM: The biomolecular simulation program
- (2009) B. R. Brooks et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity
- (2009) H. Xu et al. JOURNAL OF VIROLOGY
- Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies
- (2009) M. S. Seaman et al. JOURNAL OF VIROLOGY
- A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies
- (2009) R. Pejchal et al. JOURNAL OF VIROLOGY
- Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region
- (2009) G. Ofek et al. JOURNAL OF VIROLOGY
- Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface
- (2009) L. Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of HIV membrane in neutralization by two broadly neutralizing antibodies
- (2009) S. M. Alam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1
- (2008) Gary R. Matyas et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane
- (2008) Zhen-Yu J. Sun et al. IMMUNITY
- Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site
- (2008) Jean-Philippe Julien et al. JOURNAL OF MOLECULAR BIOLOGY
- Membrane lipids: where they are and how they behave
- (2008) Gerrit van Meer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
- (2008) G. Frey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryoelectron Tomography of HIV-1 Envelope Spikes: Further Evidence for Tripod-Like Legs
- (2008) Ping Zhu et al. PLoS Pathogens
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