Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function
Authors
Keywords
-
Journal
PLoS Pathogens
Volume 8, Issue 7, Pages e1002806
Publisher
Public Library of Science (PLoS)
Online
2012-07-20
DOI
10.1371/journal.ppat.1002806
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1
- (2011) Claudia R. Ruprecht et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Direct Antibody Access to the HIV-1 Membrane-Proximal External Region Positively Correlates with Neutralization Sensitivity
- (2011) B. K. Chakrabarti et al. JOURNAL OF VIROLOGY
- Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization
- (2011) Mikyung Kim et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant
- (2011) Javier Guenaga et al. PLoS One
- Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41
- (2011) S. Moses Dennison et al. PLoS One
- Nef Decreases HIV-1 Sensitivity to Neutralizing Antibodies that Target the Membrane-proximal External Region of TMgp41
- (2011) Rachel P.J. Lai et al. PLoS Pathogens
- Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding
- (2010) J. P. Julien et al. JOURNAL OF VIROLOGY
- Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1
- (2010) M. Pancera et al. JOURNAL OF VIROLOGY
- Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region
- (2010) Nathan I Nicely et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
- (2010) R. Pejchal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Elicitation of structure-specific antibodies by epitope scaffolds
- (2010) G. Ofek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Architectures of Trimeric SIV and HIV-1 Envelope Glycoproteins on Intact Viruses: Strain-Dependent Variation in Quaternary Structure
- (2010) Tommi A. White et al. PLoS Pathogens
- Structure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation†,‡
- (2009) Jie Liu et al. BIOCHEMISTRY
- Role of a Putative gp41 Dimerization Domain in Human Immunodeficiency Virus Type 1 Membrane Fusion
- (2009) J. Liu et al. JOURNAL OF VIROLOGY
- Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region
- (2009) G. Ofek et al. JOURNAL OF VIROLOGY
- HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane
- (2008) Zhen-Yu J. Sun et al. IMMUNITY
- Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site
- (2008) Jean-Philippe Julien et al. JOURNAL OF MOLECULAR BIOLOGY
- Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens
- (2008) M.-Y. Zhang et al. JOURNAL OF VIROLOGY
- Molecular architecture of native HIV-1 gp120 trimers
- (2008) Jun Liu et al. NATURE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started