Caenorhabditis elegans Neuromuscular Junction: GABA Receptors and Ivermectin Action

Interactions of anthelmintic drugs in Caenorhabditis elegans neuro-muscular ion channel mutants

(2013) Sandra M. Miltsch et al.   PARASITOLOGY INTERNATIONAL

Macrocyclic Lactone Anthelmintics: Spectrum of Activity and Mechanism of Action

(2012) Timothy G. Geary et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Measurement of ivermectin concentrations in target worms and host gastrointestinal tissues: Influence of the route of administration on the activity against resistant Haemonchus contortus in lambs

(2012) M. Lloberas et al.   EXPERIMENTAL PARASITOLOGY

Nematode cys-loop GABA receptors: biological function, pharmacology and sites of action for anthelmintics

(2012) Michael V. Accardi et al.   INVERTEBRATE NEUROSCIENCE

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new approach for anthelmintic discovery for humans

(2012) Timothy G. Geary et al.   TRENDS IN PARASITOLOGY

Ivermectin binding sites in human and invertebrate Cys-loop receptors

(2012) Timothy Lynagh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Relative Neurotoxicity of Ivermectin and Moxidectin in Mdr1ab (−/−) Mice and Effects on Mammalian GABA(A) Channel Activity

(2012) Cécile Ménez et al.   PLoS Neglected Tropical Diseases

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

(2012) Timothy Lynagh et al.   Frontiers in Molecular Neuroscience

Caenorhabditis elegans Body Mechanics Are Regulated by Body Wall Muscle Tone

(2011) Bryan C. Petzold et al.   BIOPHYSICAL JOURNAL

A comparison of glycine- and ivermectin-mediated conformational changes in the glycine receptor ligand-binding domain

(2011) Qian Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Determinants of Ivermectin Sensitivity at the Glycine Receptor Chloride Channel

(2011) Timothy Lynagh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Relationships between Agonist Binding Sites and Coupling Regions of Homomeric Cys-Loop Receptors

(2011) N. Andersen et al.   JOURNAL OF NEUROSCIENCE

New insights into the structural bases of activation of Cys-loop receptors

(2011) Cecilia Bouzat   JOURNAL OF PHYSIOLOGY-PARIS

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Glutamate-Gated Chloride Channels of Haemonchus contortus Restore Drug Sensitivity to Ivermectin Resistant Caenorhabditis elegans

(2011) Susan K. Glendinning et al.   PLoS One

Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: Modulation by macrocyclic lactone anthelmintics and a receptor for piperazine

(2011) David D.R. Brown et al.   VETERINARY PARASITOLOGY

A Cys-loop Mutation in theCaenorhabditis elegansNicotinic Receptor Subunit UNC-63 Impairs but Does Not Abolish Channel Function

(2010) Andrew K. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic Acetylcholine Receptor Transmembrane Mutations Convert Ivermectin from a Positive to a Negative Allosteric Modulator

(2010) T. Collins et al.   MOLECULAR PHARMACOLOGY

Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor

(2010) Feyza Sancar et al.   NEUROPHARMACOLOGY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Comparative pharmacology and computational modelling yield insights into allosteric modulation of human α7 nicotinic acetylcholine receptors

(2009) David B. Sattelle et al.   BIOCHEMICAL PHARMACOLOGY

An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse

(2009) Ruta B Almedom et al.   EMBO JOURNAL

Structural Basis of Activation of Cys-Loop Receptors: the Extracellular–Transmembrane Interface as a Coupling Region

(2009) Mariana Bartos et al.   MOLECULAR NEUROBIOLOGY