Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

Repurposing strategies for tropical disease drug discovery

(2016) Dana M. Klug et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

(2016) Lucy Glover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond Tsetse – Implications for Research and Control of Human African Trypanosomiasis Epidemics

(2016) Susan C. Welburn et al.   TRENDS IN PARASITOLOGY

Identification of “Preferred” Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

(2016) Emanuele Amata et al.   ACS Infectious Diseases

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

(2015) Simone J. Woods et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Future treatment options for human African trypanosomiasis

(2015) Amy J Jones et al.   Expert Review of Anti-Infective Therapy

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: Expression site control from both ends?

(2015) Arthur Günzl et al.   GENE

Identification of the ISWI Chromatin Remodeling Complex of the Early Branching EukaryoteTrypanosoma brucei

(2015) Tara Stanne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

(2015) J. R. Devlin et al.   Cancer Discovery

Monitoring the Progress towards the Elimination of Gambiense Human African Trypanosomiasis

(2015) Pere P. Simarro et al.   PLoS Neglected Tropical Diseases

Leishmania is not prone to develop resistance to tamoxifen

(2015) Adriano C. Coelho et al.   International Journal for Parasitology-Drugs and Drug Resistance

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

(2015) Laureen Colis et al.   Oncotarget

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

(2014) Karita Peltonen et al.   CANCER CELL

Treatment options for second-stage gambiense human African trypanosomiasis

(2014) Gilles Eperon et al.   Expert Review of Anti-Infective Therapy

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

(2014) Jeannine Diesch et al.   Cell and Bioscience

Drug repurposing and human parasitic protozoan diseases

(2014) Katherine T. Andrews et al.   International Journal for Parasitology-Drugs and Drug Resistance

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context inVSGexpression control

(2013) Lucy Glover et al.   CELLULAR MICROBIOLOGY

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

(2013) Ross D Hannan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets

(2013) Joanna Bidzinska et al.   MOLECULES

TDP1 is an HMG chromatin protein facilitating RNA polymerase I transcription in African trypanosomes

(2013) Mani Shankar Narayanan et al.   NUCLEIC ACIDS RESEARCH

Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei

(2013) T. N. Nguyen et al.   NUCLEIC ACIDS RESEARCH

Genetic dissection of drug resistance in trypanosomes

(2013) SAM ALSFORD et al.   PARASITOLOGY

A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis

(2013) Peter Babokhov et al.   Pathogens and Global Health

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

The Trypanosomatid-Specific N Terminus of RPA2 Is Required for RNA Polymerase I Assembly, Localization, and Function

(2012) Jan-Peter Daniels et al.   EUKARYOTIC CELL

Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics

(2012) Mustapha Haddach et al.   ACS Medicinal Chemistry Letters

Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei

(2012) Megan L. Povelones et al.   PLoS Pathogens

Target repurposing for neglected diseases

(2011) Michael P Pollastri et al.   Future Medicinal Chemistry

Drug resistance in human African trypanosomiasis

(2011) Michael P Barrett et al.   Future Microbiology

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

(2010) Karita Peltonen et al.   PLoS One

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi

(2010) Kirsten Gillingwater et al.   VETERINARY PARASITOLOGY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of Leishmania braziliensis and Leishmania chagasi infections

(2008) D. C. Miguel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei

(2008) Christiane Hertz-Fowler et al.   PLoS One