Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 11, Pages 2569-2576Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.03.103
Keywords
Drug repurposing; Target repurposing; Lead repurposing; Target class repurposing; Neglected tropical disease; Tropical disease; Piggy-back drug discovery; Drug repositioning
Categories
Funding
- National Institutes of Health [R56AI099476, R01AI114685]
- American Chemical Society Division of Medicinal Chemistry
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Neglected tropical diseases (NTDs) and other diseases of the developing world, such as malaria, attract research investments that are disproportionately low compared to their impact on human health worldwide. Therefore, pragmatic methods for launching new drug discovery programs have emerged that repurpose existing chemical matter as new drugs or new starting points for optimization. In this Digest we describe applications of different repurposing approaches for NTDs, and provide a means by which these approaches may be differentiated from each other. These include drug repurposing, target repurposing, target class repurposing, and lead repurposing. (C) 2016 Elsevier Ltd. All rights reserved.
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