Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli

A Life Investigating Pathways That Repair Broken Chromosomes

(2016) James E. Haber   Annual Review of Genetics

Prompt repair of hydrogen peroxide-induced DNA lesions prevents catastrophic chromosomal fragmentation

(2016) Tulip Mahaseth et al.   DNA REPAIR

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

(2016) David W. Wyatt et al.   MOLECULAR CELL

Biological and physiological role of reactive oxygen species - the good, the bad and the ugly

(2015) L. Zuo et al.   Acta Physiologica

Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in Starving Escherichia coli

(2015) J. M. Moore et al.   GENETICS

Cyanide enhances hydrogen peroxide toxicity by recruiting endogenous iron to trigger catastrophic chromosomal fragmentation

(2015) Tulip Mahaseth et al.   MOLECULAR MICROBIOLOGY

A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis

(2015) Michelle K. Scotland et al.   PLoS Genetics

Mutational Signatures Indicative of Environmental Stress in Bacteria

(2014) Ram Maharjan et al.   MOLECULAR BIOLOGY AND EVOLUTION

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

(2014) Wouter Koole et al.   Nature Communications

8-oxoguanine causes spontaneous de novo germline mutations in mice

(2014) Mizuki Ohno et al.   Scientific Reports

The DinB•RecA complex ofEscherichia colimediates an efficient and high-fidelity response to ubiquitous alkylation lesions

(2013) Tiziana M. Cafarelli et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination

(2013) Richard T Pomerantz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines

(2013) N. P. Degtyareva et al.   NUCLEIC ACIDS RESEARCH

R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli

(2013) Hallie Wimberly et al.   Nature Communications

Mutations Arising During Repair of Chromosome Breaks

(2012) Anna Malkova et al.   Annual Review of Genetics

Stress-induced mutation via DNA breaks inEscherichia coli: A molecular mechanism with implications for evolution and medicine

(2012) Susan M. Rosenberg et al.   BIOESSAYS

Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

(2012) Brian R. Berquist et al.   CANCER LETTERS

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

THE EVOLUTION OF STRESS-INDUCED HYPERMUTATION IN ASEXUAL POPULATIONS

(2012) Yoav Ram et al.   EVOLUTION

Escherichia coli DNA Polymerase IV (Pol IV), but Not Pol II, Dynamically Switches with a Stalled Pol III* Replicase

(2012) J. M. H. Heltzel et al.   JOURNAL OF BACTERIOLOGY

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

A switch between DNA polymerases   and   promotes error-free bypass of 8-oxo-G lesions

(2012) E. Markkanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics

(2012) J. J. Foti et al.   SCIENCE

Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

(2012) A. A. M. Al Mamun et al.   SCIENCE

Two Mechanisms Produce Mutation Hotspots at DNA Breaks in Escherichia coli

(2012) Chandan Shee et al.   Cell Reports

Replication Forks Stalled at Ultraviolet Lesions Are Rescued via RecA and RuvABC Protein-catalyzed Disintegration inEscherichia coli

(2011) Sharik R. Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Postreplication repair mechanisms in the presence of DNA adducts in Escherichia coli

(2011) Marc Bichara et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli

(2011) C. Shee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Separate DNA Pol II- and Pol IV-Dependent Pathways of Stress-Induced Mutation during Double-Strand-Break Repair in Escherichia coli Are Controlled by RpoS

(2010) R. L. Frisch et al.   JOURNAL OF BACTERIOLOGY

The σE stress response is required for stress-induced mutation and amplification in Escherichia coli

(2010) Janet L. Gibson et al.   MOLECULAR MICROBIOLOGY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila

(2010) Sze Ham Chan et al.   PLoS Genetics

Metabolic response to MMS-mediated DNA damage inSaccharomyces cerevisiaeis dependent on the glucose concentration in the medium

(2009) Ana Kitanovic et al.   FEMS YEAST RESEARCH

DinB Upregulation Is the Sole Role of the SOS Response in Stress-Induced Mutagenesis in Escherichia coli

(2009) R. S. Galhardo et al.   GENETICS

Stress-Induced  -Lactam Antibiotic Resistance Mutation and Sequences of Stationary-Phase Mutations in the Escherichia coli Chromosome

(2009) J. F. Petrosino et al.   JOURNAL OF BACTERIOLOGY

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

(2009) P. J. Hastings et al.   PLoS Genetics

Segmental Duplications Arise from Pol32-Dependent Repair of Broken Forks through Two Alternative Replication-Based Mechanisms

(2008) Celia Payen et al.   PLoS Genetics

Hypermutability of Damaged Single-Strand DNA Formed at Double-Strand Breaks and Uncapped Telomeres in Yeast Saccharomyces cerevisiae

(2008) Yong Yang et al.   PLoS Genetics