Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

UmuD2Inhibits a Non-covalent Step during DinB-mediated Template Slippage on Homopolymeric Nucleotide Runs

(2010) James J. Foti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

Magic spot: (p) ppGpp

(2009) Jun Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

(2009) Bryan W. Davies et al.   MOLECULAR CELL

Critical amino acids in human DNA polymerases η and κ involved in erroneous incorporation of oxidized nucleotides

(2009) Atsushi Katafuchi et al.   NUCLEIC ACIDS RESEARCH

Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase

(2009) C. Indiani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

(2008) Michael A. Kohanski et al.   CELL

Overproduction ofEscherichia coliDNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal

(2008) Kaori Uchida et al.   MOLECULAR MICROBIOLOGY

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase   replication fidelity

(2008) Z. F. Pursell et al.   NUCLEIC ACIDS RESEARCH