DNA replication stress restricts ribosomal DNA copy number

SIR2suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences

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A Signature of Genomic Instability Resulting from Deficient Replication Licensing

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Mutations in CDC45 , Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis

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Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

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More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance

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Global analysis of genomic instability caused by DNA replication stress inSaccharomyces cerevisiae

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rDNA Copy Number Variants Are Frequent Passenger Mutations in Saccharomyces cerevisiae Deletion Collections and de Novo Transformants

(2016) Elizabeth X. Kwan et al.   G3-Genes Genomes Genetics

Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication

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Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

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Hst3p, a histone deacetylase, promotes maintenance of Saccharomyces cerevisiae chromosome III lacking efficient replication origins

(2015) Carmela Irene et al.   MOLECULAR GENETICS AND GENOMICS

Regulation of ribosomal DNA amplification by the TOR pathway

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Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes

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PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress

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The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription

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A Sequence-Specific Interaction between the Saccharomyces cerevisiae rRNA Gene Repeats and a Locus Encoding an RNA Polymerase I Subunit Affects Ribosomal DNA Stability

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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae

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Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans

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A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

(2013) Elizabeth X. Kwan et al.   PLoS Genetics

Cohesin Proteins Promote Ribosomal RNA Production and Protein Translation in Yeast and Human Cells

(2012) Tania Bose et al.   PLoS Genetics

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

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Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast

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Monitoring the Rate and Dynamics of Concerted Evolution in the Ribosomal DNA Repeats of Saccharomyces cerevisiae Using Experimental Evolution

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Systematic exploration of essential yeast gene function with temperature-sensitive mutants

(2011) Zhijian Li et al.   NATURE BIOTECHNOLOGY

Mutations in the pre-replication complex cause Meier-Gorlin syndrome

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Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma

(2011) M E Rusiniak et al.   ONCOGENE

Ribosomal DNA Deletions Modulate Genome-Wide Gene Expression: “rDNA–Sensitive” Genes and Natural Variation

(2011) Silvana Paredes et al.   PLoS Genetics

Cis-interactions between non-coding ribosomal spacers dependent on RNAP-II separate RNAP-I and RNAP-III transcription domains

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DNA damage response and tumorigenesis in Mcm2-deficient mice

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Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity

(2010) S. Ide et al.   SCIENCE

Cohesin: Its Roles and Mechanisms

(2009) Kim Nasmyth et al.   Annual Review of Genetics

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Toward a Comprehensive Temperature-Sensitive Mutant Repository of the Essential Genes of Saccharomyces cerevisiae

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Low Levels of DNA Polymerase Alpha Induce Mitotic and Meiotic Instability in the Ribosomal DNA Gene Cluster of Saccharomyces cerevisiae

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