The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

Histone Mutants Separate R Loop Formation from Genome Instability Induction

(2017) Desiré García-Pichardo et al.   MOLECULAR CELL

Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation

(2017) Sreerama Chaitanya Sridhara et al.   Cell Reports

Topoisomerase I‐mediated cleavage at unrepaired ribonucleotides generates DNA double‐strand breaks

(2016) Shar‐yin N Huang et al.   EMBO JOURNAL

TERRA promotes telomerase‐mediated telomere elongation inSchizosaccharomyces pombe

(2016) Martin Moravec et al.   EMBO REPORTS

Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

(2016) Sonia Silva et al.   GENES & DEVELOPMENT

Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1

(2016) Xiaoyu Xue et al.   GENES & DEVELOPMENT

Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE

(2016) Sarah Moradi-Fard et al.   PLoS Genetics

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance

(2015) Demis Menolfi et al.   MOLECULAR CELL

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breaking bad: R-loops and genome integrity

(2015) Julie Sollier et al.   TRENDS IN CELL BIOLOGY

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

(2015) María L. García-Rubio et al.   PLoS Genetics

A Saccharomyces cerevisiae RNase H2 Interaction Network Functions To Suppress Genome Instability

(2014) S. Allen-Soltero et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

Restriction of Replication Fork Regression Activities by a Conserved SMC Complex

(2014) Xiaoyu Xue et al.   MOLECULAR CELL

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

High Nutrient Levels and TORC1 Activity Reduce Cell Viability following Prolonged Telomere Dysfunction and Cell Cycle Arrest

(2014) Julia Klermund et al.   Cell Reports

Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip

(2014) Yujia A. Chan et al.   PLoS Genetics

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

(2013) Verena Pfeiffer et al.   EMBO JOURNAL

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres

(2013) Emilio Cusanelli et al.   MOLECULAR CELL

Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA

(2013) Jessica S. Williams et al.   MOLECULAR CELL

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNase H2 roles in genome integrity revealed by unlinking its activities

(2013) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

(2013) Jessica Marinello et al.   NUCLEIC ACIDS RESEARCH

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

(2012) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mph1 Helicase Can Promote Telomere Uncapping and Premature Senescence in Budding Yeast

(2012) Sarah Luke-Glaser et al.   PLoS One

Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 protein

(2011) Xiao-Feng Zheng et al.   DNA REPAIR

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

(2011) Belén Gómez-González et al.   EMBO JOURNAL

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast

(2011) Nahid Iglesias et al.   EMBO REPORTS

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability

(2011) Hannah E. Mischo et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

(2011) Doryen Bubeck et al.   NUCLEIC ACIDS RESEARCH

Mismatch Repair, But Not Heteroduplex Rejection, Is Temporally Coupled to DNA Replication

(2011) H. Hombauer et al.   SCIENCE

The FANCM family of DNA helicases/translocases

(2010) Matthew C. Whitby   DNA REPAIR

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

Sumoylation and the Structural Maintenance of Chromosomes (Smc) 5/6 Complex Slow Senescence through Recombination Intermediate Resolution

(2010) Alejandro Chavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Smc5/6 Complex and Esc2 Influence Multiple Replication-associated Recombination Processes in Saccharomyces cerevisiae

(2010) Koyi Choi et al.   MOLECULAR BIOLOGY OF THE CELL

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling

(2009) Sarah Luke-Glaser et al.   EMBO JOURNAL

TERRA: telomeric repeat-containing RNA

(2009) Brian Luke et al.   EMBO JOURNAL

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

The DNA damage response at eroded telomeres and tethering to the nuclear pore complex

(2009) Basheer Khadaroo et al.   NATURE CELL BIOLOGY

Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair

(2009) Yu-Hung Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New Purple Fluorescent Color Marker for Genetic Studies in Saccharomyces cerevisiae and Candida albicans

(2008) S. Keppler-Ross et al.   GENETICS

Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination

(2008) Soma Banerjee et al.   JOURNAL OF CELL BIOLOGY

Smc5/6: a link between DNA repair and unidirectional replication?

(2007) Johanne M. Murray et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY