A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions

Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks

(2016) Daisuke Sato et al.   BIOPHYSICAL JOURNAL

Mitochondria-derived ROS bursts disturb Ca2+ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: a theoretical study

(2015) Qince Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcium-Voltage Coupling in the Genesis of Early and Delayed Afterdepolarizations in Cardiac Myocytes

(2015) Zhen Song et al.   BIOPHYSICAL JOURNAL

Changes in T-Tubules and Sarcoplasmic Reticulum in Ventricular Myocytes in Early Cardiac Hypertrophy in a Pressure Overload Rat Model

(2015) Perla Pérez-Treviño et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Perturbed atrial calcium handling in an ovine model of heart failure: Potential roles for reductions in the L-type calcium current

(2015) Jessica D. Clarke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

T-tubule disruption promotes calcium alternans in failing ventricular myocytes: Mechanistic insights from computational modeling

(2015) Michael Nivala et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

t-tubule disease: Relationship between t-tubule organization and regional contractile performance in human dilated cardiomyopathy

(2015) David J. Crossman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

(2015) Simon M. Bryant et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcium Alternans is Due to an Order-Disorder Phase Transition in Cardiac Cells

(2015) Enrique Alvarez-Lacalle et al.   PHYSICAL REVIEW LETTERS

Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes

(2015) Vijay Rajagopal et al.   PLoS Computational Biology

Superresolution Modeling of Calcium Release in the Heart

(2014) Mark A. Walker et al.   BIOPHYSICAL JOURNAL

Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions

(2014) David J. Greensmith et al.   CARDIOVASCULAR RESEARCH

Dependence of Cardiac Transverse Tubules on the BAR Domain Protein Amphiphysin II (BIN-1)

(2014) Jessica L. Caldwell et al.   CIRCULATION RESEARCH

Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells

(2014) Michael D. Stern et al.   JOURNAL OF GENERAL PHYSIOLOGY

Serial block face scanning electron microscopy for the study of cardiac muscle ultrastructure at nanoscale resolutions

(2014) Christian Pinali et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Formation of Spatially Discordant Alternans Due to Fluctuations and Diffusion of Calcium

(2014) Daisuke Sato et al.   PLoS One

Emerging mechanisms of T-tubule remodelling in heart failure

(2013) Ang Guo et al.   CARDIOVASCULAR RESEARCH

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation

(2013) Niels Voigt et al.   CIRCULATION

Three-Dimensional Reconstruction of Cardiac Sarcoplasmic Reticulum Reveals a Continuous Network Linking Transverse-Tubules

(2013) Christian Pinali et al.   CIRCULATION RESEARCH

Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria

(2013) Michael A. Colman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Criticality in Intracellular Calcium Signaling in Cardiac Myocytes

(2012) Michael Nivala et al.   BIOPHYSICAL JOURNAL

Mechanisms by which Cytoplasmic Calcium Wave Propagation and Alternans Are Generated in Cardiac Atrial Myocytes Lacking T-Tubules—Insights from a Simulation Study

(2012) Qince Li et al.   BIOPHYSICAL JOURNAL

The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities

(2012) S. Nattel et al.   EUROPEAN HEART JOURNAL

Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture

(2012) D.R. Laver et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A functional role for transverse (t-) tubules in the atria

(2012) Katharine M. Dibb et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcium flux balance in the heart

(2012) David Eisner et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Data-based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes

(2012) Leonid Livshitz et al.   JOURNAL OF PHYSIOLOGY-LONDON

An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation

(2012) Stefano Severi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Toward an Integrative Computational Model of the Guinea Pig Cardiac Myocyte

(2012) Laura Doyle Gauthier et al.   Frontiers in Physiology

Computational Modeling and Numerical Methods for Spatiotemporal Calcium Cycling in Ventricular Myocytes

(2012) Michael Nivala et al.   Frontiers in Physiology

Multiscale Modeling of Calcium Cycling in Cardiac Ventricular Myocyte: Macroscopic Consequences of Microscopic Dyadic Function

(2011) Namit Gaur et al.   BIOPHYSICAL JOURNAL

Dynamics of Calcium Sparks and Calcium Leak in the Heart

(2011) George S.B. Williams et al.   BIOPHYSICAL JOURNAL

Multiscale Modeling of Calcium Dynamics in Ventricular Myocytes With Realistic Transverse Tubules

(2011) Zeyun Yu et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

A localized meshless approach for modeling spatial-temporal calcium dynamics in ventricular myocytes

(2011) Guangming Yao et al.   International Journal for Numerical Methods in Biomedical Engineering

Changes in the Organization of Excitation-Contraction Coupling Structures in Failing Human Heart

(2011) David J. Crossman et al.   PLoS One

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Spark-Induced Sparks As a Mechanism of Intracellular Calcium Alternans in Cardiac Myocytes

(2010) Robert Rovetti et al.   CIRCULATION RESEARCH

Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes

(2010) P. Li et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Numerical Analysis of Ca2+ Signaling in Rat Ventricular Myocytes with Realistic Transverse-Axial Tubular Geometry and Inhibited Sarcoplasmic Reticulum

(2010) Yuhui Cheng et al.   PLoS Computational Biology

Three-dimensional high-resolution imaging of cardiac proteins to construct models of intracellular Ca2+signalling in rat ventricular myocytes

(2009) Christian Soeller et al.   EXPERIMENTAL PHYSIOLOGY

Calsequestrin-Mediated Mechanism for Cellular Calcium Transient Alternans

(2008) Juan G. Restrepo et al.   BIOPHYSICAL JOURNAL

Calcium Cycling and Signaling in Cardiac Myocytes

(2007) Donald M. Bers   Annual Review of Physiology