Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells

Structural and Functional Alteration of RyR Clusters After Remodeling in Persistent Atrial Fibrillation

(2015) Niall Macquaide et al.   BIOPHYSICAL JOURNAL

RyR-NCX-SERCA Local Cross-Talk Ensures Pacemaker Cell Function at Rest and During the Fight-or-Flight Reflex

(2013) Anna V. Maltsev et al.   CIRCULATION RESEARCH

Life and death of a cardiac calcium spark

(2013) Michael D. Stern et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle

(2013) Dirk Gillespie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca2+ clock generate robust, flexible, and energy-efficient cardiac pacemaking

(2013) Victor A. Maltsev et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ca2+ channel nanodomains boost local Ca2+ amplitude

(2013) M. R. Tadross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: Insights from bifurcation analysis of mathematical models

(2012) Yasutaka Kurata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Criticality in Intracellular Calcium Signaling in Cardiac Myocytes

(2012) Michael Nivala et al.   BIOPHYSICAL JOURNAL

Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Patricia Neco et al.   CIRCULATION

Ryanodine Receptor Current Amplitude Controls Ca 2+ Sparks in Cardiac Muscle

(2012) Tao Guo et al.   CIRCULATION RESEARCH

Characterizing Phospholamban to Sarco(endo)plasmic Reticulum Ca2+-ATPase 2a (SERCA2a) Protein Binding Interactions in Human Cardiac Sarcoplasmic Reticulum Vesicles Using Chemical Cross-linking

(2012) Brandy L. Akin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture

(2012) D.R. Laver et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation

(2012) Stefano Severi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synchronization of Stochastic Ca2+ Release Units Creates a Rhythmic Ca2+ Clock in Cardiac Pacemaker Cells

(2011) Anna V. Maltsev et al.   BIOPHYSICAL JOURNAL

Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity

(2011) Hena R. Ramay et al.   CARDIOVASCULAR RESEARCH

Dynamic Calcium Movement Inside Cardiac Sarcoplasmic Reticulum During Release

(2011) Eckard Picht et al.   CIRCULATION RESEARCH

Distribution and Functional Role of Inositol 1,4,5- tris phosphate Receptors in Mouse Sinoatrial Node

(2011) Yue-Kun Ju et al.   CIRCULATION RESEARCH

The funny current has a major pacemaking role in the sinus node

(2011) Dario DiFrancesco et al.   HEART RHYTHM

Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells

(2010) Yukiko Himeno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes

(2010) P. Li et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model

(2009) Victor A. Maltsev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Three-dimensional high-resolution imaging of cardiac proteins to construct models of intracellular Ca2+signalling in rat ventricular myocytes

(2009) Christian Soeller et al.   EXPERIMENTAL PHYSIOLOGY

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes

(2008) Sabine Huke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanism of Local and Global Ca2+ Sensing by Calmodulin in Complex with a Ca2+ Channel

(2008) Michael R. Tadross et al.   CELL