Predicting drug–target interactions through integrative analysis of chemogenetic assays in yeast

Mining high-throughput screens for cancer drug targets-lessons from yeast chemical-genomic profiling and synthetic lethality

(2012) Marja A. Heiskanen et al.   Wiley Interdisciplinary Reviews-Data Mining and Knowledge Discovery

Chemical-genomic profiling: Systematic analysis of the cellular targets of bioactive molecules

(2011) Kerry Andrusiak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A quantitative analysis of monochromaticity in genetic interaction networks

(2011) Chien-Hsiang Hsu et al.   BMC BIOINFORMATICS

Searching for synthetic lethality in cancer

(2011) Rachel Brough et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Discovering the Targets of Drugs Via Computational Systems Biology: FIGURE 1.

(2011) Hon Nian Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae

(2011) Craig M. Tamble et al.   Molecular BioSystems

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

STITCH 3: zooming in on protein-chemical interactions

(2011) M. Kuhn et al.   NUCLEIC ACIDS RESEARCH

Saccharomyces Genome Database: the genomics resource of budding yeast

(2011) J. M. Cherry et al.   NUCLEIC ACIDS RESEARCH

Inference of Protein Complex Activities from Chemical-Genetic Profile and Its Applications: Predicting Drug-Target Pathways

(2011) Sangjo Han et al.   PLoS Computational Biology

Protein Complexes are Central in the Yeast Genetic Landscape

(2011) Magali Michaut et al.   PLoS Computational Biology

The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics

(2011) Tara A Gianoulis et al.   GENOME BIOLOGY

Charting the genetic interaction map of a cell

(2010) Michael Costanzo et al.   CURRENT OPINION IN BIOTECHNOLOGY

Combining functional genomics and chemical biology to identify targets of bioactive compounds

(2010) Cheuk Hei Ho et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthetic lethality: General principles, utility and detection using genetic screens in human cells

(2010) Sebastian M.B. Nijman   FEBS LETTERS

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

(2010) Laura Kapitzky et al.   Molecular Systems Biology

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

A survey of yeast genomic assays for drug and target discovery

(2010) Andrew M. Smith et al.   PHARMACOLOGY & THERAPEUTICS

Rewiring of Genetic Networks in Response to DNA Damage

(2010) S. Bandyopadhyay et al.   SCIENCE

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action

(2010) Maureen E Hillenmeyer et al.   GENOME BIOLOGY

High-confidence mapping of chemical compounds and protein complexes reveals novel aspects of chemical stress response in yeast

(2009) Thiago M. Venancio et al.   Molecular BioSystems

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE