Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment

Human haematopoietic stem cell lineage commitment is a continuous process

(2017) Lars Velten et al.   NATURE CELL BIOLOGY

Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells

(2017) Rhishikesh Bargaje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

(2016) Philipp S. Hoppe et al.   NATURE

Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process

(2016) Angélique Richard et al.   PLOS BIOLOGY

Cell Fate Decision as High-Dimensional Critical State Transition

(2016) Mitra Mojtahedi et al.   PLOS BIOLOGY

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

(2015) Nicola K. Wilson et al.   Cell Stem Cell

Hypoxic culture conditions enhance the generation of regulatory T cells

(2015) Thi My Anh Neildez-Nguyen et al.   IMMUNOLOGY

Single-cell messenger RNA sequencing reveals rare intestinal cell types

(2015) Dominic Grün et al.   NATURE

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Primed and ready: understanding lineage commitment through single cell analysis

(2015) Rachael A. Nimmo et al.   TRENDS IN CELL BIOLOGY

Single Cell Dynamics Causes Pareto-Like Effect in Stimulated T Cell Populations

(2015) Jérémie Cosette et al.   Scientific Reports

Epigenetic reprogramming induces the expansion of cord blood stem cells

(2014) Pratima Chaurasia et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Stochastic Fluctuations and Distributed Control of Gene Expression Impact Cellular Memory

(2014) Guillaume Corre et al.   PLoS One

Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages

(2014) André Görgens et al.   Stem Cell Reports

Synthesis and degradation jointly determine the responsiveness of the cellular proteome

(2013) Björn Schwanhäusser et al.   BIOESSAYS

Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts

(2013) José Viñuelas et al.   BMC BIOLOGY

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis

(2013) Victoria Moignard et al.   NATURE CELL BIOLOGY

Concise Review: Erythroid Versus Myeloid Lineage Commitment: Regulating the Master Regulators

(2013) Linda Wolff et al.   STEM CELLS

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

(2012) Yosef Buganim et al.   CELL

Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells

(2012) Kenneth J. Livak et al.   METHODS

Inferring rules of lineage commitment in haematopoiesis

(2012) Cristina Pina et al.   NATURE CELL BIOLOGY

What makes the cell differentiate?

(2012) Andras Paldi   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A Dynamical-Systems View of Stem Cell Biology

(2012) C. Furusawa et al.   SCIENCE

Haematopoietic stem cell differentiation promotes the release of prominin-1/CD133-containing membrane vesicles-a role of the endocytic-exocytic pathway

(2011) Nicola Bauer et al.   EMBO Molecular Medicine

High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors

(2010) C. Cattoglio et al.   BLOOD

Non-genetic heterogeneity of cells in development: more than just noise

(2009) S. Huang   DEVELOPMENT

The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells

(2009) T. Kobayashi et al.   GENES & DEVELOPMENT

Forcing cells to change lineages

(2009) Thomas Graf et al.   NATURE

A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid–lymphoid dichotomy

(2009) Hiroshi Kawamoto et al.   TRENDS IN IMMUNOLOGY

Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States

(2008) Katsuhiko Hayashi et al.   Cell Stem Cell

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

(2008) Hannah H. Chang et al.   NATURE