FGFR3–TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle

FGFR3-TACC3 fusion proteins act as naturally occurring drivers of tumor resistance by functionally substituting for EGFR/ERK signaling

(2016) C Daly et al.   ONCOGENE

FGFR3-TACC3 fusion in solid tumors: mini review

(2016) Ricardo Costa et al.   Oncotarget

The Role of Aneuploidy in Cancer Evolution

(2016) Laurent Sansregret et al.   Cold Spring Harbor Perspectives in Medicine

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations

(2015) Leandro H. Gallo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization

(2015) Yirui Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1

(2015) Y. Nakanishi et al.   MOLECULAR CANCER THERAPEUTICS

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

(2015) Selena G. Burgess et al.   PLoS Genetics

The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle

(2015) Faye M Nixon et al.   eLife

TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation

(2015) C. Gutierrez-Caballero et al.   Biology Open

Direct kinetochore–spindle pole connections are not required for chromosome segregation

(2014) Vitali Sikirzhytski et al.   JOURNAL OF CELL BIOLOGY

The Centrosomal Adaptor TACC3 and the Microtubule Polymerase chTOG Interact via Defined C-terminal Subdomains in an Aurora-A Kinase-independent Manner

(2013) Harish C. Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of adjacent domains mediates TACC3–ch-TOG–clathrin assembly and mitotic spindle binding

(2013) Fiona E. Hood et al.   JOURNAL OF CELL BIOLOGY

Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension

(2013) L. P. Cheeseman et al.   JOURNAL OF CELL SCIENCE

Parallel RNA Interference Screens Identify EGFR Activation as an Escape Mechanism in FGFR3-Mutant Cancer

(2013) M. T. Herrera-Abreu et al.   Cancer Discovery

Fusion genes in solid tumors: an emerging target for cancer diagnosis and treatment

(2013) Brittany C. Parker et al.   Chinese Journal of Cancer

Oncogenic FGFR3 gene fusions in bladder cancer

(2012) Sarah V. Williams et al.   HUMAN MOLECULAR GENETICS

Clathrin-mediated endocytosis is inhibited during mitosis

(2012) A. B. Fielding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

(2012) D. Singh et al.   SCIENCE

A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging

(2011) Daniel G Booth et al.   EMBO JOURNAL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability

(2010) Chiou-Hong Lin et al.   JOURNAL OF CELL BIOLOGY

Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment

(2010) W. Fu et al.   JOURNAL OF CELL SCIENCE

The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program

(2010) S Schmidt et al.   ONCOGENE