Molecules in pain and sex: a developing story

Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia

(2016) Justin S. Ko et al.   BRAIN BEHAVIOR AND IMMUNITY

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Sex differences in neuroimmunity and pain

(2016) Sarah Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

(2016) Takahiro Masuda et al.   Nature Communications

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

(2016) Ryoichi Tashima et al.   Scientific Reports

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

(2016) Nan Gu et al.   Cell Reports

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing

(2016) Michael E. Hildebrand et al.   Cell Reports

Evidence for brain glial activation in chronic pain patients

(2015) Marco L. Loggia et al.   BRAIN

Delayed Activation of Spinal Microglia Contributes to the Maintenance of Bone Cancer Pain in Female Wistar Rats via P2X7 Receptor and IL-18

(2015) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Opinion: Sex inclusion in basic research drives discovery: Fig. 1.

(2015) Sabra L. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals

(2014) Wenling Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Female mice liberated for inclusion in neuroscience and biomedical research

(2014) Brian J. Prendergast et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Sex differences in pain: a brief review of clinical and experimental findings

(2013) E.J. Bartley et al.   BRITISH JOURNAL OF ANAESTHESIA

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

The known knowns of microglia–neuronal signalling in neuropathic pain

(2013) Simon Beggs et al.   NEUROSCIENCE LETTERS

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Chronic-Pain-Associated Astrocytic Reaction in the Spinal Cord Dorsal Horn of Human Immunodeficiency Virus-Infected Patients

(2012) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

P2X4R+ microglia drive neuropathic pain

(2012) Simon Beggs et al.   NATURE NEUROSCIENCE

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Peroxisome proliferator-activated receptor (PPAR)  and -  regulate IFN  and IL-17A production by human T cells in a sex-specific way

(2012) M. A. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages

(2011) Russell P. Landry et al.   EXPERIMENTAL NEUROLOGY

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Direct transcriptional targets of sex steroid hormones in bone

(2010) Susan A. Krum   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular Depletion of Descending Serotonin Unmasks Its Novel Facilitatory Role in the Development of Persistent Pain

(2010) F. Wei et al.   JOURNAL OF NEUROSCIENCE

Sex bias in neuroscience and biomedical research

(2010) Annaliese K. Beery et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies

(2010) Marieke Niesters et al.   PAIN

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain

(2009) Marina Asiedu et al.   PAIN

Spinal cord histopathological alterations in a patient with longstanding complex regional pain syndrome

(2008) Luis Del Valle et al.   BRAIN BEHAVIOR AND IMMUNITY

CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain

(2008) Ling Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

(2008) Xue Jun Liu et al.   NATURE MEDICINE

Prevalence of chronic pain with neuropathic characteristics in the general population

(2007) Didier Bouhassira et al.   PAIN