mTOR inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing COX-2 and PGE2

Mesenchymal stromal cells and immunomodulation: A gathering of regulatory immune cells

(2016) Mehdi Najar et al.   CYTOTHERAPY

Rapamycin Augments Immunomodulatory Properties of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis

(2016) Mansoureh Togha et al.   MOLECULAR NEUROBIOLOGY

Mesenchymal stem cells and immunomodulation: current status and future prospects

(2016) F Gao et al.   Cell Death & Disease

Phenotypical and Functional Characterization of Bone Marrow Mesenchymal Stem Cells in Patients with Chronic Graft-versus-Host Disease

(2015) Binsheng Wang et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs

(2015) John Girdlestone et al.   CYTOTHERAPY

TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition

(2015) Antje Thien et al.   DEVELOPMENTAL CELL

Mesenchymal Stromal Cells Disrupt mTOR-Signaling and Aerobic Glycolysis During T-Cell Activation

(2015) Martin Böttcher et al.   STEM CELLS

Insensitivity of Human iPS Cells-Derived Mesenchymal Stem Cells to Interferon-γ-induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice

(2015) Yue-Qi Sun et al.   STEM CELLS

Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation

(2015) Sally K. Martin et al.   STEM CELLS

Optimization of adipose tissue-derived mesenchymal stem cells by rapamycin in a murine model of acute graft-versus-host disease

(2015) Kyoung-Woon Kim et al.   Stem Cell Research & Therapy

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

(2014) Ying Wang et al.   NATURE IMMUNOLOGY

Interferon-Gamma Modification of Mesenchymal Stem Cells: Implications of Autologous and Allogeneic Mesenchymal Stem Cell Therapy in Allotransplantation

(2014) Kisha Nandini Sivanathan et al.   Stem Cell Reviews and Reports

Mechanisms of Immune Modulation by Mesenchymal Stromal Cells and Clinical Translation

(2013) J. Stagg et al.   CURRENT MOLECULAR MEDICINE

Critical Role of the Tumor Suppressor Tuberous Sclerosis Complex 1 in Dendritic Cell Activation of CD4 T Cells by Promoting MHC Class II Expression via IRF4 and CIITA

(2013) H. Pan et al.   JOURNAL OF IMMUNOLOGY

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma

(2013) R. B. Corcoran et al.   Science Translational Medicine

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

(2013) Sara M. Melief et al.   STEM CELLS

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

How mesenchymal stem cells interact with tissue immune responses

(2012) Yufang Shi et al.   TRENDS IN IMMUNOLOGY

Mesenchymal Stem Cells: Mechanisms of Inflammation

(2011) Nora G. Singer et al.   Annual Review of Pathology-Mechanisms of Disease

Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells

(2010) M. J. Crop et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells

(2010) Rosa Yañez et al.   EXPERIMENTAL CELL RESEARCH

Tuberous Sclerosis Complex 2 (TSC2) Regulates Cell Migration and Polarity through Activation of CDC42 and RAC1

(2010) Yan Larson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2

(2009) G. M. Spaggiari et al.   BLOOD

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

Rictor is a novel target of p70 S6 kinase-1

(2009) C Treins et al.   ONCOGENE

A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1

(2008) Huiming Sheng et al.   CELL RESEARCH

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell

MHC expression kinetics and immunogenicity of mesenchymal stromal cells after short-term IFN-γ challenge

(2008) Wing Keung Chan et al.   EXPERIMENTAL HEMATOLOGY

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY