Postulates for validating TLR4 agonists

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

(2014) C. Walsh et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: FimH Adhesin of Type 1 Fimbriae Is a Novel TLR4 Ligand

(2014) K. L. Mossman et al.   JOURNAL OF IMMUNOLOGY

A Cross-Disciplinary Perspective on the Innate Immune Responses to Bacterial Lipopolysaccharide

(2014) Yunhao Tan et al.   MOLECULAR CELL

Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators

(2013) Dessy Rachmawati et al.   CONTACT DERMATITIS

MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

(2013) Mark T. Orr et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Serum Amyloid A3 Binds MD-2 To Activate p38 and NF- B Pathways in a MyD88-Dependent Manner

(2013) A. Deguchi et al.   JOURNAL OF IMMUNOLOGY

Allergens as Immunomodulatory Proteins: The Cat Dander Protein Fel d 1 Enhances TLR Activation by Lipid Ligands

(2013) J. Herre et al.   JOURNAL OF IMMUNOLOGY

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

Cleavage of Fibrinogen by Proteinases Elicits Allergic Responses Through Toll-Like Receptor 4

(2013) V. O. Millien et al.   SCIENCE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

A Mouse Model of Salmonella Typhi Infection

(2012) Ramkumar Mathur et al.   CELL

NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

(2012) Iva Hafner-Bratkovič et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain

(2012) Fei-xiang Wu et al.   International Journal of Medical Sciences

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

(2012) Takashi Shichita et al.   NATURE MEDICINE

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification

(2012) M. Oldenburg et al.   SCIENCE

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica

(2012) Adeline M. Hajjar et al.   PLoS Pathogens

The Lipopolysaccharide Core of Brucella abortus Acts as a Shield Against Innate Immunity Recognition

(2012) Raquel Conde-Álvarez et al.   PLoS Pathogens

A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo

(2011) Austin Pantel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

(2010) Mohan R. Dasu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin

(2010) P. Tewary et al.   BLOOD

Variability in the Lipooligosaccharide Structure and Endotoxicity amongBordetella pertussisStrains

(2010) Nico Marr et al.   JOURNAL OF INFECTIOUS DISEASES

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway

(2010) Honglian Geng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Free Thiol Group of MD-2 as the Target for Inhibition of the Lipopolysaccharide-induced Cell Activation

(2009) Mateja Manček-Keber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Roles of Lysines 122, 125, and 58 in Functional Differences between Human and Murine MD-2

(2009) J. Vasl et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production

(2008) Emmanuel Lorne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

Taxanes inhibit human TLR4 signaling by binding to MD-2

(2008) Nuša Resman et al.   FEBS LETTERS

Paclitaxel Binding to Human and Murine MD-2

(2008) Shanta M. Zimmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helicobacter pyloriProtein HP0175 Transactivates Epidermal Growth Factor Receptor through TLR4 in Gastric Epithelial Cells

(2008) Sanchita Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

(2008) Aurelien Trompette et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY