A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses
Authors
Keywords
-
Journal
Scientific Reports
Volume 7, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-11-07
DOI
10.1038/s41598-017-15258-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach
- (2017) H. Ongun Onaran et al. Scientific Reports
- A comprehensive map of molecular drug targets
- (2016) Rita Santos et al. NATURE REVIEWS DRUG DISCOVERY
- A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain
- (2016) Eugene R. Viscusi et al. PAIN
- Functional studies cast light on receptor states
- (2015) Frederick J. Ehlert TRENDS IN PHARMACOLOGICAL SCIENCES
- Molecular Mechanisms of Bitopic Ligand Engagement with the M1Muscarinic Acetylcholine Receptor
- (2014) Peter Keov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biased ligands at G-protein-coupled receptors: promise and progress
- (2014) Jonathan D. Violin et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist
- (2013) S. Hennen et al. Science Signaling
- Structure-Function of the G Protein–Coupled Receptor Superfamily
- (2012) Vsevolod Katritch et al. Annual Review of Pharmacology and Toxicology
- Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism
- (2012) David Roche et al. DRUG DISCOVERY TODAY
- Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation
- (2011) Cassandra Koole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantifying Ligand Bias at Seven-Transmembrane Receptors
- (2011) S. Rajagopal et al. MOLECULAR PHARMACOLOGY
- Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
- (2011) Arun K. Shukla et al. TRENDS IN BIOCHEMICAL SCIENCES
- Identification of Orthosteric and Allosteric Site Mutations in M2Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias
- (2010) Karen J. Gregory et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization
- (2010) J. McPherson et al. MOLECULAR PHARMACOLOGY
- Receptor reserve reflects differential intrinsic efficacy associated with opioid diastereomers
- (2009) Richard D.S. Carliss et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Selectivity of Agonists for the Active State of M1 to M4 Muscarinic Receptor Subtypes
- (2008) K. W. Figueroa et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- On the analysis of ligand-directed signaling at G protein-coupled receptors
- (2008) Frederick J. Ehlert NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search