Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma

PKM2 Thr454 phosphorylation increases its nuclear translocation and promotes xenograft tumor growth in A549 human lung cancer cells

(2016) Zhenhai Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells

(2016) Joydeep Mukherjee et al.   INTERNATIONAL JOURNAL OF CANCER

Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome

(2016) Goran Hamid Mohammad et al.   PLoS One

MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer

(2015) Kohei Taniguchi et al.   CANCER LETTERS

Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions

(2015) Xi Chen et al.   CANCER SCIENCE

AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma

(2015) Jung-Hee Kwon et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells

(2015) Yan-Ling Chen   WORLD JOURNAL OF GASTROENTEROLOGY

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

Hepatocellular carcinoma epidemiology

(2014) Cristina Bosetti et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer

(2014) C Papadaki et al.   BRITISH JOURNAL OF CANCER

PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells

(2014) Haili Wu et al.   CELLULAR SIGNALLING

Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling

(2014) Peng Yang et al.   CELLULAR SIGNALLING

TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma

(2014) Z Chen et al.   ONCOGENE

Nuclear PKM2 regulates the Warburg effect

(2013) Weiwei Yang et al.   CELL CYCLE

PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancer

(2013) J. Li et al.   Clinical & Translational Oncology

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

New aspects of the Warburg effect in cancer cell biology

(2012) Steven J. Bensinger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Molecular mechanism of size control in development and human diseases

(2011) Xiaolong Yang et al.   CELL RESEARCH

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer as a metabolic disease

(2010) Thomas N Seyfried et al.   Nutrition & Metabolism

Hepatocellular carcinoma in non-cirrhotic liver: A reappraisal

(2009) Franco Trevisani et al.   DIGESTIVE AND LIVER DISEASE

Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study

(2008) U Haug et al.   BRITISH JOURNAL OF CANCER

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Clinicopathologic Features and Long-Term Outcomes of Chinese Patients with Hepatocellular Carcinoma in Non-Cirrhotic Liver

(2008) Li Xu et al.   DIGESTIVE SURGERY