IMM-H004, a coumarin derivative, attenuated brain ischemia/reperfusion injuries and subsequent inflammation in spontaneously hypertensive rats through inhibition of VCAM-1

Hypertension unawareness among Chinese patients with first-ever stroke

(2016) Qinqin Cao et al.   BMC PUBLIC HEALTH

The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation

(2016) Mingcheng Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Post-ischemic salubrinal treatment results in a neuroprotective role in global cerebral ischemia

(2016) Berta Anuncibay-Soto et al.   JOURNAL OF NEUROCHEMISTRY

TNF-α enhances vascular cell adhesion molecule-1 expression in human bone marrow mesenchymal stem cells via the NF-κB, ERK and JNK signaling pathways

(2016) ZI-YUAN LU et al.   Molecular Medicine Reports

Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion

(2016) Shi-Feng Chu et al.   MOLECULAR NEUROBIOLOGY

Nafamostat mesilate protects against acute cerebral ischemia via blood–brain barrier protection

(2016) Jing Wang et al.   NEUROPHARMACOLOGY

Neurovascular coupling protects neurons against hypoxic injury via inhibition of potassium currents by generation of nitric oxide in direct neuron and endothelium cocultures

(2016) Kun-Wei Wu et al.   NEUROSCIENCE

Ivabradine Prevents Low Shear Stress Induced Endothelial Inflammation and Oxidative Stress via mTOR/eNOS Pathway

(2016) Bing Li et al.   PLoS One

Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation

(2016) Byung Soo Kong et al.   PLoS One

Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries

(2016) Luong Le et al.   THROMBOSIS AND HAEMOSTASIS

Erythrocyte rheological properties but not whole blood and plasma viscosity are associated with severity of hypertension in older people

(2016) Guo-xiang Fu et al.   ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE

Effects of cerebral glucose levels in infarct areas on stroke injury mediated by blood glucose changes

(2016) Shuai Zhang et al.   RSC Advances

Compound IMM-H004, a Novel Coumarin Derivative, Protects against CA1 Cell Loss and Spatial Learning Impairments Resulting from Transient Global Ischemia

(2015) Wei Zuo et al.   CNS Neuroscience & Therapeutics

Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats

(2015) Rafik Balti et al.   FOOD CHEMISTRY

The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation

(2015) Wenlu Li et al.   JOURNAL OF NEUROCHEMISTRY

Chemokine-Like Factor 1-Derived C-Terminal Peptides Induce the Proliferation of Dermal Microvascular Endothelial Cells in Psoriasis

(2015) Yaqi Tan et al.   PLoS One

Arterial Hypertension Aggravates Innate Immune Responses after Experimental Stroke

(2015) Karoline Möller et al.   Frontiers in Cellular Neuroscience

Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells

(2015) Guo-qian He et al.   Molecular Brain

Magnolol Reduced TNF-α-Induced Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells via JNK/p38 and NF-κB Signaling Pathways

(2014) Chan-Jung Liang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

RETRACTED: Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen–glucose deprivation

(2014) Tomasz Urbanek et al.   BRAIN RESEARCH

IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia

(2014) Xiu-Yun Song et al.   BRAIN RESEARCH BULLETIN

IMM-H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA-and PI3K-dependent Akt activation

(2014) Wei Zuo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Novel Antihypertensive Lactoferrin-Derived Peptides Produced by Kluyveromyces marxianus: Gastrointestinal Stability Profile and In Vivo Angiotensin I-Converting Enzyme (ACE) Inhibition

(2014) Aurora García-Tejedor et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats

(2014) Ling Kong et al.   Journal of Neuroinflammation

Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: The role of inhibition of Drp1 in ischemic brain damage

(2014) Wei Zuo et al.   NEUROPHARMACOLOGY

Inflammatory cell recruitment after experimental thromboembolic stroke in rats

(2014) J. Lehmann et al.   NEUROSCIENCE

Salusin-β, but Not Salusin-α, Promotes Human Umbilical Vein Endothelial Cell Inflammation via the p38 MAPK/JNK-NF-κB Pathway

(2014) Cheng-Hua Zhou et al.   PLoS One

Ischemic neurons recruit natural killer cells that accelerate brain infarction

(2014) Y. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycophenolic acid attenuates the tumour necrosis factor-α-mediated proinflammatory response in endothelial cells by blocking the MAPK/NF-κB and ROS pathways

(2013) Wioletta Olejarz et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Mechanosensitive microRNAs—role in endothelial responses to shear stress and redox state

(2013) Traci Marin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of JNK and NF-κB pathways in Porphyromonas gingivalis LPS-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells

(2013) BIN LIU et al.   Molecular Medicine Reports

Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: results from a randomized clinical trial

(2012) Khosrow S Houschyar et al.   BMC Medicine

Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats

(2012) Yong Pan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of Intensive Blood Pressure Lowering on Cardiovascular and Renal Outcomes: A Systematic Review and Meta-Analysis

(2012) Jicheng Lv et al.   PLOS MEDICINE

Brain inflammation is induced by co-morbidities and risk factors for stroke

(2011) Caroline Drake et al.   BRAIN BEHAVIOR AND IMMUNITY

Viscolin reduces VCAM-1 expression in TNF-α-treated endothelial cells via the JNK/NF-κB and ROS pathway

(2011) Chan-Jung Liang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of p38 Mitogen-Activated Protein Kinase Pathway inPorphyromonas gingivalisLipopolysaccharide–Induced VCAM-1 Expression in Human Aortic Endothelial Cells

(2011) Bin Liu et al.   JOURNAL OF PERIODONTOLOGY

Neuroprotection by local intra-arterial infusion of erythropoietin after focal cerebral ischemia in rats

(2011) Sha Dang et al.   NEUROLOGICAL RESEARCH

Benzene toxicity: The role of the susceptibility factor NQO1 in bone marrow endothelial cell signaling and function

(2010) David Ross et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells

(2010) Tzu-Ming Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Involvement of MAPKs and NF-κB in tumor necrosis factor α–induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts

(2009) Shue-Fen Luo et al.   ARTHRITIS AND RHEUMATISM

Chemokine-like factor 1, a novel cytokine, induces nerve cell migration through the non-extracellular Ca2+-dependent tyrosine kinases pathway

(2009) Zhen-Zhen Wang et al.   BRAIN RESEARCH

The Role of the Ubiquitin Proteasome System in Ischemia and Ischemic Tolerance

(2009) Robert Meller   NEUROSCIENTIST

Effect of parenteral or oral vinpocetine on the hemorheological parameters of patients with chronic cerebrovascular diseases

(2009) Gergely Feher et al.   PHYTOMEDICINE

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The cost of cerebral ischaemia

(2008) R.W.V. Flynn et al.   NEUROPHARMACOLOGY