Article
Nanoscience & Nanotechnology
Eugenia Belcastro, Asad Ur Rehman, Lamia Remila, Sin-Hee Park, Dal Seong Gong, Nicolas Anton, Cyril Auger, Olivier Lefebvre, Jacky G. Goetz, Mayeul Collot, Andrey S. Klymchenko, Thierry F. Vandamme, Valerie B. Schini-Kerth
Summary: Endothelial senescence is identified as an early event in cardiovascular disease development. Theranostic nanocarriers decorated with VCAM-1 antibodies show potential in targeting senescent endothelial cells, and loading with omega 3 polyunsaturated fatty acids may effectively prevent senescence in endothelial cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yan-rou Bei, Shun-chi Zhang, Yu Song, Mao-lin Tang, Ke-lan Zhang, Min Jiang, Run-chao He, Shao-guo Wu, Xue-hui Liu, Li-mei Wu, Xiao-yan Dai, Yan-wei Hu
Summary: Atherosclerosis is a chronic inflammatory disease in which monocyte adhesion to endothelial cells plays a crucial role. This study shows that the novel gene EPSTI1 is significantly upregulated in atherosclerotic plaques and promotes monocyte adhesion to endothelial cells by increasing the expression of VCAM-1 and ICAM-1. The expression of EPSTI1 is regulated by LPS and is dependent on p65 nuclear translocation. These findings suggest that EPSTI1 may play a potential role in the development of atherosclerosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Medical Laboratory Technology
Varinder Singh, Rupinder Kaur, Pratima Kumari, Chirag Pasricha, Ravinder Singh
Summary: Leukocyte migration is vital for lymphocyte recirculation and immune response. ICAM-1 and VCAM-1 play a crucial role in leukocyte adherence to endothelial cells in various diseases. They contribute to inflammation, leukocyte migration, and have implications in multiple pathological states. Understanding their immunoregulatory role and pathophysiological effects helps in disease management.
CLINICA CHIMICA ACTA
(2023)
Article
Clinical Neurology
Qianwen Lv, Haili Sun, Zhiyong Du, Xiaolu Jiao, Huahui Yu, Qiuju Sun, Fan Li, Yu Wang, Linyi Li, Chaowei Hu, Yanwen Qin
Summary: The study revealed a significant association between circulating VCAM-1 levels and the presence of CAD in Chinese adults with moderate to severe OSA, suggesting VCAM-1 as a potential novel biomarker for monitoring the development and progression of CAD in this population.
Article
Pharmacology & Pharmacy
Xinyu Zhu, Jiangtong Peng, Liuye Yang, Yi Guo, Pengchao Wang, Kaiyuan Liu, Jingbo Zhu, Shan Deng, Minglu Liang
Summary: This study demonstrates the inhibitory effect of 7-Mif on endothelial inflammation by reducing the expression of endothelial adhesion molecules and monocyte adhesion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Shuangfei Li, Boyu Wang, Liangxu Liu, Yingjie Song, Chuhan Lv, Xingyu Zhu, Yanqing Luo, Christopher H. K. Cheng, Huapu Chen, Xuewei Yang, Tao Li
Summary: The study demonstrates that adding Aurantiochytrium sp. to diets can significantly improve the growth performance and immune response of Trachinotus ovatus. With increased microalgae content, the growth rate and feed utilization efficiency of fish were enhanced, along with increased fatty acid content in blood and tissues, resulting in improved immunity and disease resistance in fish.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Environmental Sciences
Weixuan Wang, Shuang Li, Xi Wang, Jianbo Wang, Yanshu Zhang
Summary: This study investigated the effect of nano-PbO exposure on lymphocyte cells infiltration and adhesion protein expression in the choroid plexus, as well as the role of reactive oxygen species (ROS) in the process. Results showed that nano-PbO exposure increased lymphocyte cell percentage and upregulated ICAM-1 and VCAM-1 expression. Additionally, nano-PbO treatment led to increased ROS production and decreased antioxidant activity. Inhibition of ROS significantly decreased ICAM-1 and VCAM-1 expression. In conclusion, nano-PbO exposure increases ICAM-1 and VCAM-1 expression through oxidative stress, facilitating lymphocyte infiltration into the brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biology
Sandra Marinovic Kulisic, Marta Takahashi, Marta Himelreich Peric, Vedrana Muzic Radovic, Ruzica Jurakic Toncic
Summary: This study evaluated the expression of E-selectin, ICAM-1, and VCAM-1 in skin biopsy specimens of patients with AD using a computer program. The results showed that the number of ICAM-1 and VCAM-1 positive cells decreased, while the E-selectin positive epidermal surface area increased in AD patients. The endothelial area positive for E-selectin and ICAM1 was significantly larger in AD-affected skin. In addition, strong signals of E-selectin were detected in skin macrophages and ICAM-1 in dermal vessel endothelium. VCAM-1 signal could not be found in the endothelial cells of AD-affected skin. The expression of E-selectin, ICAM-1, and VCAM-1 shows significant changes in AD-affected skin compared to control skin.
Article
Biochemistry & Molecular Biology
Weiwei Zeng, Zhiyuan Sun, Tengxiang Ma, Xiaobin Song, Shuai Li, Qianqian Zhang, Wen Yuan, Jing Li, Li Liu, Minsheng Zhu, Huaqun Chen
Summary: Leucocyte adhesion to the vascular endothelium is regulated by the expression of cell adhesion molecules (CAMs), primarily under the influence of TNF-alpha through ZIPK activation and gene expression. TNF-alpha-induced ZIPK plays a crucial role in CAM expression and leucocyte adhesion, functioning upstream of NF-kappa B signaling. The findings suggest a TNF-alpha/ZIPK/NF-kappa B signaling axis for CAM expression that is essential for leucocyte adhesion to endothelial cells and may serve as a potential target for anti-inflammatory drug exploration.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Pharmacology & Pharmacy
Ching-Kai Shen, Bor-Ren Huang, Wei-Lan Yeh, Chao-Wei Chen, Yu-Shu Liu, Sheng-Wei Lai, Wen-Pei Tseng, Dah-Yuu Lu, Cheng-Fang Tsai
Summary: This study showed that IL-1 beta induces the expression of ICAM-1 and VCAM-1 in GBM cells, leading to increased adhesive interaction between monocytes and GBM cells. Additionally, IL-1 beta also triggers the production of soluble ICAM-1 and VCAM-1 in GBM, which plays a crucial role in regulating tumor-associated monocyte/macrophage polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Joon Ho Park, Yao Jiang, Jiarong Zhou, Hua Gong, Animesh Mohapatra, Jiyoung Heo, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: By exploiting the specific affinity between VLA-4 and VCAM-1, a biomimetic nanoparticle formulation capable of targeting inflammation sites was developed. These nanoparticles coated with cell membranes showed enhanced affinity to target cells, improving the delivery of anti-inflammatory drugs to inflamed lungs and demonstrating significant therapeutic efficacy in vivo.
Article
Oncology
Safiye Aktas, Pinar Ercetin, Zekiye Altun, Mehmet Kantar, Nur Olgun
Summary: In this in vitro study, it was found that EPA did not promote proliferation in most cancer cells and did not affect the cytotoxic effects of chemotherapy drugs. Additionally, it was observed that EPA had some proliferative effects on fibroblasts, but did not reduce the toxicity of chemotherapy drugs on these cells.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Hematology
Do Huu Chi, Tomoaki Kahyo, Ariful Islam, Md Mahmudul Hasan, A. S. M. Waliullah, Md Al Mamun, Madoka Nakajima, Takenori Ikoma, Keitaro Akita, Yuichiro Maekawa, Tomohito Sato, Mitsutoshi Setou
Summary: Supplementation of docosahexaenoic acid or eicosapentaenoic acid to the Western diet resulted in higher levels of NAD(+), FAD(+), and their metabolites in the aortic arch.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Nutrition & Dietetics
Melanie Gsoellpointner, Margarita Thanhaeuser, Fabian Eibensteiner, Robin Ristl, Bernd Jilma, Renate Fuiko, Sophia Brandstetter, Angelika Berger, Nadja Haiden
Summary: This study analyzed the intake of polyunsaturated fatty acids (PUFAs) during complementary feeding (CF) in very low birth weight (VLBW) infants and its impact on neurodevelopment. The results showed that higher intake of total PUFAs, docosahexaenoic acid (DHA), and arachidonic acid (AA) was associated with improved cognitive and motor function at 12 months of age. However, the dietary intake of AA and DHA did not meet the recommended levels, highlighting the need to increase PUFA, DHA, and AA intake during CF for better neurodevelopmental outcomes in VLBW infants.
Article
Biotechnology & Applied Microbiology
Qian Zhang, Wei Zhang, Jing Liu, Haisen Yang, Yuxia Hu, Mengdi Zhang, Tuya Bai, Fuhou Chang
Summary: The study investigated the regulatory role of LPC on endothelial cell adhesion marker expression, suggesting that the LPC-G2A-ICAM-1/VCAM-1 pathway may contribute to atherogenic activity of oxLDL, with NF-kappa B antagonists potentially serving as effective therapeutic tools for cardiovascular diseases.
Article
Neurosciences
Hsueh-Te Lee, Kuan-I Lee, Hui-Ching Lin, Tzong-Shyuan Lee
MOLECULAR NEUROBIOLOGY
(2019)
Article
Physiology
Jin-Feng Zhao, Hsiang-Ying Chen, Jeng Wei, Shr-Jeng Jim Leu, Tzong-Shyuan Lee
Article
Physiology
An-Hsuan Lin, Meng-Han Liu, Hsin-Kuo Ko, Diahn-Warng Perng, Tzong-Shyuan Lee, Yu Ru Kou
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Cell Biology
Chih-Chan Lien, Chia-Hui Chen, Yeng-Ming Lee, Bei-Chia Guo, Li-Ching Cheng, Ching-Chien Pan, Song-Kun Shyue, Tzong-Shyuan Lee
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Chia-Hui Chen, Jin-Feng Zhao, Chiao-Po Hsu, Yu Ru Kou, Tse-Min Lu, Tzong-Shyuan Lee
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Medicine, General & Internal
Chung-Kuan Wu, Chia-Lin Wu, Tzu-Cheng Su, Yu Ru Kou, Chew-Teng Kor, Tzong-Shyuan Lee, Der-Cherng Tarng
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Nutrition & Dietetics
Po-An Hu, Chia-Hui Chen, Bei-Chia Guo, Yu Ru Kou, Tzong-Shyuan Lee
Article
Biochemistry & Molecular Biology
Chung-Kuan Wu, Chia-Lin Wu, Tzong-Shyuan Lee, Yu Ru Kou, Der-Cherng Tarng
Summary: The study found that TRPA1 plays a role in AKI by sensing oxidative stress and regulating inflammation in renal tubular cells. TRPA1 expression increased in patients with AKI and in a mouse model of IR-induced injury, highlighting its importance in kidney injury. In vitro experiments showed that TRPA1 activation by ROS under hypoxia-reoxygenation injury conditions led to increased intracellular Ca2+ level and activation of inflammatory signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chung-Kuan Wu, Ji-Fan Lin, Tzong-Shyuan Lee, Yu Ru Kou, Der-Cherng Tarng
Summary: TRPA1 plays dual roles in sensory neurons and non-neuronal cells, promoting tissue repair, clearing harmful stimuli, and inducing protective responses, while also potentially contributing to disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Man-Chen Hsu, Wei-Jia Luo, Bei-Chia Guo, Chia-Hui Chen, Po-An Hu, Yi-Hsuan Tsai, Kang-Yi Su, Tzong-Shyuan Lee
Summary: In this study, the role of HLJ1 in blood coagulation was investigated using wild-type mice and HLJ1-null mice. The results suggest that although HLJ1 is present in megakaryocytes and platelets, it may not play a role in blood coagulation under normal physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Po-An Hu, Sz-Han Wang, Chia-Hui Chen, Bei-Chia Guo, Jenq-Wen Huang, Tzong-Shyuan Lee
Summary: Bromelain has anticoagulant effects on non-alcoholic fatty liver disease-induced blood coagulation deregulation by inhibiting the activation of the coagulation cascade, decreasing the stability of clots, and promoting fibrinolytic activity. The findings suggest the potential therapeutic value of bromelain for thrombosis-related diseases.
Article
Biochemistry & Molecular Biology
Chia-Hui Chen, Chien-Chung Hsia, Po-An Hu, Chung-Hsin Yeh, Chun-Tang Chen, Cheng-Liang Peng, Chih-Hsien Wang, Tzong-Shyuan Lee
Summary: Bromelain, a cysteine protease found in pineapple, has been found to have beneficial effects in the treatment of inflammatory diseases. In this study, the effects of bromelain on hyperlipidemia and atherosclerosis in mice were investigated. It was found that daily administration of bromelain improved hyperlipidemia, reduced aortic inflammation, and slowed down the progression of atherosclerosis. The mechanisms underlying these effects involve the promotion of cholesteryl ester hydrolysis, autophagy, and antioxidant capacity through the AMPK/TFEB signaling pathway.
Article
Biochemistry & Molecular Biology
Ko-Lin Kuo, Chin-Wei Chiang, Yi-Ming Arthur Chen, Chih-Chin Yu, Tzong-Shyuan Lee
Summary: Folic acid has anti-inflammatory and antifibrotic effects. The major folic acid-binding protein in the liver, GNMT, regulates cellular methylation and may be a therapeutic target in treating renal fibrosis. Increased expression of GNMT was observed in humans with obstructive nephropathy and in mice with unilateral ureteral obstruction. Folic acid treatment alleviated renal injury in wild-type mice, but not in GNMT knockout mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Transplantation
Ko-Lin Kuo, Der-Cherng Tarng, Tzong-Shyuan Lee
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2018)
Article
Cell Biology
Chia-Hui Chen, Song-Kun Shyue, Chiao-Po Hsu, Tzong-Shyuan Lee
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)