Review
Pharmacology & Pharmacy
Xiaowei Xie, Tianxiang Yue, Wenting Gu, Weiyi Cheng, Li He, Weiye Ren, Fanzhu Li, Ji-Gang Piao
Summary: This paper discusses the use of surface-functionalized mesoporous silica nanoparticles (MSN) as delivery vehicles for siRNA in cancer therapy. The advantages of using MSNs for siRNA loading and strategies to improve cellular uptake and endosomal escape are highlighted. Attention is also paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes.
Article
Nanoscience & Nanotechnology
Yunsheng Zheng, Wenfeng Guo, Lingwei Hu, Zekai Xiao, Xianzhu Yang, Ziyang Cao, Jie Cao
Summary: Cancer nanomedicine treatment aims to achieve specific targeting to cancer cells. By coating nanoparticles with cell membranes, they acquire new functions and properties, including targeting and long circulation. In this study, a hybrid biomimetic nanomedicine was developed for colon cancer therapy, which showed prolonged circulation and targeted function to provide a bioinspired strategy for chemophotodynamic synergistic therapy of colon cancer.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Han Zhang, Karen Kelly, Jonathan Lee, Dimas Echeverria, David Cooper, Rebecca Panwala, Nadia Amrani, Zexiang Chen, Nicholas Gaston, Atish Wagh, Gregory A. Newby, Jun Xie, David R. Liu, Guangping Gao, Scot A. Wolfe, Anastasia Khvorova, Jonathan K. Watts, Erik J. Sontheimer
Summary: This study demonstrates the use of chemical modification and protecting oligos to enhance the potency and stability of heavily modified crRNA in CRISPR-Cas9 genome editing. The co-delivery of chemically modified crRNAs with protecting oligos and AAV vectors enables in vivo genome editing in adult mouse liver and central nervous system, offering potential for transient editing activity and target multiplexing.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Engineering, Biomedical
Xiaoli Wu, Han Yang, Xingmeng Chen, Junxiao Gao, Yue Duan, Daohe Wei, Jinchao Zhang, Kun Ge, Xing-Jie Liang, Yuanyu Huang, Sizhou Feng, Rongli Zhang, Xi Chen, Jin Chang
Summary: A new immunotherapy approach combining innate immune activator and photodynamic therapy reagent has shown promising results in treating colon cancer, effectively inhibiting tumor growth, promoting immune cell infiltration, and enhancing cytotoxicity of immune cells. This approach may serve as an effective and safe platform for combinatory use with nano-herb medicine and PDT, providing a new therapy option for colon cancer treatment.
Article
Chemistry, Multidisciplinary
Bowon Lee, Ok Kyu Park, Limin Pan, Kang Kim, Taegyu Kang, Hyunjoong Kim, Nohyun Lee, Seung Hong Choi, Taeghwan Hyeon
Summary: Simultaneous inhibition of lactate metabolism and intracellular acidification using a co-delivery system of lactate transporter inhibitor, glucose oxidase, and O2-evolving nanoparticles shows high anticancer efficacy without toxicity in normal tissues. This study provides new insights into synergistic metabolic modulation in tumors using co-delivery of small-molecule drugs, proteins, and nanoparticles.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Yuanyuan Guo, Qiushuang Zhang, Qiwen Zhu, Jing Gao, Xinyuan Zhu, Haijun Yu, Yuehua Li, Chuan Zhang
Summary: This study presents a rational design and assembly of a nanocarrier that can package multiple drugs, including small-molecule drugs and macromolecular biologics. The nanogel not only achieves photodynamic therapy but also targets gene silencing, leading to enhanced antitumor immune response in a synergistic manner.
Article
Chemistry, Multidisciplinary
Qin Ouyang, Kai Liu, Qubo Zhu, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan, Wenhu Zhou, Jianbin Tong
Summary: Alzheimer's disease (AD) is a common form of dementia in elderly individuals, with no effective treatment currently available. This study presents a novel DNA nanoflowers-based delivery system for AD therapy, which allows exogenous supplementation of miR-124 to ameliorate AD-like pathology. The nanosystem demonstrates promising results in increasing miR-124 levels in the brain and achieving robust therapeutic efficacy in a mouse model of AD.
Review
Biochemistry & Molecular Biology
Biying Yan, Yaxuan Liang
Summary: Extracellular vesicles (EVs) have been recognized as superior vectors for drug or gene delivery, and recent studies have highlighted their importance in CRISPR gene editing, especially in cancer treatment. This review discusses the strategies and limitations of constructing EV-CRISPR vectors, and emphasizes the clinical potential of engineered EVs in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zhenkun Ren, Xibin Han, Lixin Wang, Yi Wang
Summary: The study found that AS/GOD@HAZnO nanoparticles could effectively inhibit tumors and improve drug efficacy through responsive release. These nanoparticles, which can be efficiently taken in by tumor cells through the affinity between hyaluronic acid and CD44 receptors, release drugs in an acidic environment, thereby inhibiting tumor growth.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Lin Huang, Mengyang Zhou, Ghulam Abbas, Chao Li, Mengmeng Cui, Xian-En Zhang, Dian-Bing Wang
Summary: A cancer cell membrane-derived nanocarrier was developed for synergistic photothermal/gene therapy. This nanotherapeutic platform showed high biocompatibility, homologous targeting capacity, and efficient payload delivery, leading to enhanced therapeutic efficacy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Materials Science, Biomaterials
Bruna G. Carvalho, Franciele F. Vit, Hernandes F. Carvalho, Sang W. Han, Lucimara G. de la Torre
Summary: Nanocarrier delivery systems have been developed to overcome the multidrug-resistance of cells to antineoplastic medicines, allowing for more effective treatment. Co-delivery of different agents such as drugs and genetic materials can achieve synergistic therapeutic effects. Future trends involve designing novel nano-scale platforms for co-delivering therapeutic agents.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Junli Meng, Peisen Zhang, Qizhe Chen, Zihua Wang, Yuan Gu, Jie Ma, Wang Li, Chen Yang, Yuanyuan Qiao, Yi Hou, Lihong Jing, Yong Wang, Zi Gu, Lichong Zhu, Haozhen Xu, Xueguang Lu, Mingyuan Gao
Summary: Nanovaccines that can co-deliver antigen and adjuvant to dendritic cells have emerged as effective tools for activating antitumor immune responses, inhibiting tumor growth, and improving survival rates.
ADVANCED MATERIALS
(2022)
Review
Medicine, Research & Experimental
Xiao Wei, Mingzhu Song, Weijie Li, Jing Huang, Guang Yang, Yi Wang
Summary: The primary cause of chemotherapy failure is cancer multidrug resistance (MDR), leading to recurrence and metastasis of cancer. Dual-therapeutic combination using multifunctional nanoplatforms is gaining attention for overcoming resistant cancers. Smart co-delivery nanocarriers can improve drug properties, enhance therapeutic efficacy, and even overcome drug resistance.
Article
Medicine, Research & Experimental
Xinglong Fan, Tian Wang, Zhongyi Ji, Qingpeng Li, Hongyu Shen, Jun Wang
Summary: The study successfully constructed DDP and ORI co-loaded layer-by-layer nanoparticles, which showed significant in vitro and in vivo anti-tumor effects against DDP-resistant lung cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Yidan Sun, Chunyue An, Luyan Wu, Wenhui Zeng, Jiafeng Wang, Yanfeng Wang, Jian He, Guandao Gao, Deju Ye
Summary: The US-activated hybrid FeCuS-lipid nanoparticles showed promising therapeutic efficacy in deep-located orthotopic gastric tumors in living mice, enhancing tumor uptake and promoting hydroxyl radical production to induce tumor ferroptosis. The addition of disulfiram further synergized the therapeutic effect by chelating with liberated Cu2+ and yielding toxic chelates to ablate deep-seated orthotopic gastric tumors.