Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy

Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

(2020) Mi Hyeon Cho et al.   Nano-Micro Letters

Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer

(2020) Yanlei Liu et al.   Nano-Micro Letters

Beyond Blocking: Engineering RNAi-Mediated Targeted Immune Checkpoint Nanoblocker Enables T-Cell-Independent Cancer Treatment

(2020) Xiaoyan Han et al.   ACS Nano

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

Molecular Interactions of Antibody Drugs Targeting PD-1, PD-L1, and CTLA-4 in Immuno-Oncology

(2019) Hyun Lee et al.   MOLECULES

PD-1/PD-L1 pathway: Basic biology and role in cancer immunotherapy

(2019) Arash Salmaninejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The siRNAsome: A Cation-Free and Versatile Nanostructure for siRNA and Drug Co-delivery

(2019) Meng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stressing the Role of DNA as a Drug Carrier: Synthesis of DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides

(2019) Yuanyuan Guo et al.   ADVANCED MATERIALS

Cancer nanomedicine for combination cancer immunotherapy

(2019) Jutaek Nam et al.   Nature Reviews Materials

Immune Checkpoint Blockade Mediated by a Small‐Molecule Nanoinhibitor Targeting the PD‐1/PD‐L1 Pathway Synergizes with Photodynamic Therapy to Elicit Antitumor Immunity and Antimetastatic Effects on Breast Cancer

(2019) Rui Zhang et al.   Small

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

(2019) Claire Donohoe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The potentiated checkpoint blockade immunotherapy by ROS-responsive nanocarrier-mediated cascade chemo-photodynamic therapy

(2019) Liqin Hu et al.   BIOMATERIALS

Harnessing the Potential Synergistic Interplay Between Photosensitizer Dark Toxicity and Chemotherapy

(2019) Yan Baglo et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Laser Immunotherapy in Combination with Perdurable PD-1 Blocking for Treatment of Metastatic Tumor

(2018) Lihua Luo et al.   ACS Nano

A Crosslinked Nucleic Acid Nanogel for Effective siRNA Delivery and Antitumor Therapy

(2018) Fei Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Nanotechnology-Enabled Drug Delivery Systems

(2018) Qinqin Hu et al.   CHEMICAL REVIEWS

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Nanoscale Metal–Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

(2018) Guangxu Lan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Recent Progresses in Phototherapy-Synergized Cancer Immunotherapy

(2018) Chee Wee Ng et al.   ADVANCED FUNCTIONAL MATERIALS

Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

(2018) Tingkai Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature

(2018) Rui Bao et al.   MOLECULAR PHARMACEUTICS

Tumor ablation using low-intensity ultrasound and sound excitable drug

(2017) Ching-Hsuan Tung et al.   JOURNAL OF CONTROLLED RELEASE

A Closer Look at Dark Toxicity of the Photosensitizer TMPyP in Bacteria

(2017) Daniel B. Eckl et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle

(2016) Xuyu Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photodynamic Therapy Mediated by Nontoxic Core–Shell Nanoparticles Synergizes with Immune Checkpoint Blockade To Elicit Antitumor Immunity and Antimetastatic Effect on Breast Cancer

(2016) Xiaopin Duan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy

(2016) Dangge Wang et al.   NANO LETTERS

Ovarian Cancer Immunotherapy Using PD-L1 siRNA Targeted Delivery from Folic Acid-Functionalized Polyethylenimine: Strategies to Enhance T Cell Killing

(2015) Pei Yun Teo et al.   Advanced Healthcare Materials

Deciphering and Reversing Tumor Immune Suppression

(2013) Greg T. Motz et al.   IMMUNITY

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

(2011) Jiang Li et al.   ACS Nano

RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells

(2010) Lisa Borkner et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

2′,7′-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy

(2010) Xiuping Chen et al.   FREE RADICAL RESEARCH

Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model

(2008) A. P. Castano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA