Article
Cell Biology
Yue Li, Ruoyi Shen, Anqi Wang, Jian Zhao, Jieqi Zhou, Weijie Zhang, Ruochen Zhang, Jianjie Zhu, Zeyi Liu, Jian-an Huang
Summary: This study established an immune lncRNA risk model that can accurately predict the prognosis of patients with lung adenocarcinoma through data analysis and experimental validation. The model showed efficacy through survival curves and ROC curves, demonstrating superior predictive accuracy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Tongyan Liu, Chencheng Han, Panqi Fang, Zhifei Ma, Xiaoxiao Wang, Hao Chen, Siwei Wang, Fanchen Meng, Cheng Wang, Erbao Zhang, Guozhang Dong, Hongyu Zhu, Wenda Yin, Jie Wang, Xianglin Zuo, Mantang Qiu, Jinke Wang, Xu Qian, Hongbing Shen, Lin Xu, Zhibin Hu, Rong Yin
Summary: This study reveals that cancer-associated fibroblasts (CAFs) in lung adenocarcinoma (LUAD) primarily enhance the glutamine metabolism of cancer cells. They have identified a CAF-specific long noncoding RNA, LINC01614, which is packaged by CAF-derived exosomes and mediates the enhancement of glutamine uptake in LUAD cells. Mechanistically, LINC01614 directly interacts with ANXA2 and p65 to facilitate the activation of NF-kappa B, leading to the upregulation of the glutamine transporters SLC38A2 and SLC7A5 and enhancing the glutamine influx of cancer cells. Clinically, LINC01614 expression in CAFs is associated with the glutamine influx and poor prognosis of patients with LUAD. Blocking exosome-transmitted LINC01614 inhibits glutamine addiction and LUAD growth in vivo.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Qi Wen Chen, Qian Qian Cai, Ying Yang, Shu Dong, Yuan Yuan Liu, Zhong Yi Chen, Chun Lan Kang, Bing Qi, Yi Wei Dong, Wei Wu, Li Ping Zhuang, Ye Hua Shen, Zhi Qiang Meng, Xing Zhong Wu
Summary: This study reveals the important role and mechanism of long non-coding RNA BC in promoting tumor metastasis and influencing clinical prognosis of lung adenocarcinoma (LUAD). BC promotes growth, invasion, metastasis, and resistance to EGFR-targeted therapies in lung cancer by forming a splicing complex with nucleolin and hnRNPK. High expression of BC is associated with clinical progress and poor survival in LUAD.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Jianyuan Feng, Jiarui Zhang, Yanling Li, Weilun Cheng, Yansong Liu, Ziang Chen, Yunqiang Duan, Tianshui Yu, Anbang Hu, Ting Wang, Hanyu Zhang, Mingcui Li, Zhiyuan Rong, Fei Ma, Baoliang Guo
Summary: This study found that lncRNA PCAT19 regulates the development of breast cancer and may serve as a prognostic biomarker for breast cancer patients.
Article
Oncology
David J. Birnbaum, Sebastian K. S. Begg, Pascal Finetti, Charles Vanderburg, Anupriya S. Kulkarni, Azfar Neyaz, Thomas Hank, Eric Tai, Vikram Deshpande, Francois Bertucci, Daniel Birnbaum, Keith D. Lillemoe, Andrew L. Warshaw, Mari Mino-Kenudson, Carlos Fernandez-Del Castillo, David T. Ting, Andrew S. Liss
Summary: This study identified specific molecular subtypes of PDAC through laser capture microdissection, and found gene expression signatures associated with short-term and long-term survival. These findings provide new insights into predicting patient survival based on the cancer- and stroma-specific features of PDAC.
CLINICAL CANCER RESEARCH
(2021)
Article
Genetics & Heredity
Yinliang Lu, XueHui Luo, Qi Wang, Jie Chen, Xinyue Zhang, YueSen Li, Yuetong Chen, Xinyue Li, Suxia Han
Summary: A signature consisting of 7 necroptosis-related lncRNAs was constructed as an independent predictor for LUAD patients, showing a close relationship between the predictive signature and immune status of LUAD patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zhihua Li, Cheng Pan, Zhibo Wang, Xiaheng Deng, Quan Zhu, Weibing Wu, Liang Chen
Summary: The study identified lncRNAs associated with the functional states of LUAD cells through single-cell RNA sequencing analysis, and revealed that PCBP1-AS1 may suppress the metastasis of LUAD by targeting the epithelial-mesenchymal transition pathway, serving as a potential prognostic biomarker and therapeutic target.
Article
Cell Biology
Ming Bai, Chen Sun
Summary: In this study, a prognostic risk model for lung adenocarcinoma (LUAD) was constructed using long non-coding RNAs (lncRNAs) related to m5C RNA methylation. A total of 16 lncRNAs significantly associated with overall survival were identified. The study concluded that the m5C-lncRNA signature score was closely related to overall survival based on the constructed risk model and experimental validation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Heng Zhang, Shao-Qiang Wang, Li Wang, Hang Lin, Jie-Bo Zhu, Ri Chen, Lin-Feng Li, Yuan-Da Cheng, Chao-Jun Duan, Chun-Fang Zhang
Summary: In this study, it was found that SNHG17 promotes gefitinib resistance in LUAD by epigenetically repressing LATS2 expression via recruiting EZH2 and inducing m6A modifications.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Meghana Manjunath, Snehal Nirgude, Anisha Mhatre, Sai G. Vemuri, Mallika Nataraj, Jayanti Thumsi, Bibha Choudhary
Summary: Breast cancer is one of the leading causes of cancer-associated death in women. Despite progress in treatment, drug resistance and recurrence still impact patient survival. This study aimed to identify lncRNA and mRNA signatures in Indian breast cancer patients using RNA-seq. The analysis revealed a gene set that could segregate the different molecular subtypes of breast cancer. Survival analysis showed that menopausal status, tumor grade, and hormone status significantly affected the risk of mortality due to breast cancer.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Liwei Wu, Zilu Wen, Yanzheng Song, Lin Wang
Summary: This study screened autophagy-related lncRNAs and constructed a survival model consisting of 11 lncRNAs, confirming their significant predictive value for the prognosis of lung adenocarcinoma patients.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jun Mao, Hailong Qiu, Liling Guo
Summary: The study showed that HCG11 was downregulated in LUAD and its inhibition of lung adenocarcinoma growth was mediated by METTL14 through the IGF2BP2/LATS1 pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
HuiWei Chen, Zhimin Xie, QingZhu Li, GenYi Qu, NianXi Tan, YuLong Zhang
Summary: By constructing a risk coefficient model of necroptosis-related long non-coding RNA, novel potential biomarkers for predicting the sensitivity to chemotherapeutic agents and prognosis of patients with lung adenocarcinoma (LUAD) were identified. The model can classify patients into high-risk and low-risk groups and predict their sensitivity to chemotherapy.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Baosuo Liu, Lize San, Huayang Guo, Kecheng Zhu, Nan Zhang, Jingwen Yang, Bo Liu, Jilun Hou, Dianchang Zhang
Summary: The skin of Trachinotus ovatus plays a crucial role in the immune response to Cryptocaryon irritans infection. This study conducted a comprehensive transcriptome analysis on skin tissues to investigate the involvement of the skin in C. irritans infection. The analysis identified differentially expressed long non-coding RNAs, microRNAs, and genes, and revealed their role in signaling pathways such as tight junction, MAPK, and cell adhesion molecules. Functional prediction analysis suggested that the differentially expressed non-coding RNAs may regulate immune genes to resist C. irritans infection. Further research on these non-coding RNAs will enhance our understanding of the immune regulatory function in T. ovatus during C. irritans infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shuoyan Xu, Zhiming Cheng, Bulin Du, Yao Diao, Yaming Li, Xuena Li
Summary: This study verifies the role of AP000695.2 in glycolysis of lung adenocarcinoma (LUAD) and explores its underlying mechanism. The results indicate that high expression of AP000695.2 promotes glycolysis, cell growth, and migration in LUAD. It is also found that AP000695.2 functions as a competing endogenous RNA (ceRNA) to absorb miR-335-3p, thereby regulating the expression of TEAD1 and influencing the energy metabolism of LUAD. The findings suggest that AP000695.2 may serve as a potential target for anti-tumor energy metabolism therapy.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Medicine, Research & Experimental
Beiyun Zhou, Per Flodby, Jiao Luo, Dan R. Castillo, Yixin Liu, Fa-Xing Yu, Alicia McConnell, Bino Varghese, Guanglei Li, Nyam-Osor Chimge, Mitsuhiro Sunohara, Michael N. Koss, Wafaa Elatre, Peter Conti, Janice M. Liebler, Chenchen Yang, Crystal N. Marconett, Ite A. Laird-Offringa, Parviz Minoo, Kunliang Guan, Barry R. Stripp, Edward D. Crandall, Zea Borok
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Genetics & Heredity
Chenchen Yang, Theresa Ryan Stueve, Chunli Yan, Suhn K. Rhie, Daniel J. Mullen, Jiao Luo, Beiyun Zhou, Zea Borok, Crystal N. Marconett, Ite A. Offringa
Article
Oncology
Shandy Shahabi, Vishaly Kumaran, Jonathan Castillo, Zhengmin Cong, Gopika Nandagopal, Daniel J. Mullen, Alexander Alvarado, Michele Ramos Correa, Autumn Saizan, Riya Goel, Amrita Bhat, Sean K. Lynch, Beiyun Zhou, Zea Borok, Crystal N. Marconett
Article
Physiology
Alessandra Castaldi, Masafumi Horie, Megan E. Rieger, Mickael Dubourd, Mitsuhiro Sunohara, Kusum Pandit, Beiyun Zhou, Ite A. Offringa, Crystal N. Marconett, Zea Borok
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Genetics & Heredity
Daniel J. Mullen, Chunli Yan, Diane S. Kang, Beiyun Zhou, Zea Borok, Crystal N. Marconett, Peggy J. Farnham, Ite A. Offringa, Suhn Kyong Rhie
Article
Multidisciplinary Sciences
Caitlin Mills, Anushya Muruganujan, Dustin Ebert, Crystal N. Marconett, Juan Pablo Lewinger, Paul D. Thomas, Huaiyu Mi
Article
Oncology
Rebecca L. Mather, Abhijit Parolia, Sandra E. Carson, Erik Venalainen, David Roig-Carles, Mustapha Jaber, Shih-Chun Chu, Ilaria Alborelli, Rebecca Wu, Dong Lin, Noushin Nabavi, Elena Jachetti, Mario P. Colombo, Hui Xue, Perla Pucci, Xinpei Ci, Cheryl Hawkes, Yinglei Li, Hardev Pandha, Igor Ulitsky, Crystal Marconett, Luca Quagliata, Wei Jiang, Ignacio Romero, Yuzhuo Wang, Francesco Crea
Summary: Metastatic neuroendocrine prostate cancer (NEPC) is a highly aggressive disease with increasing incidence. The study identified LINC00261 as significantly upregulated in NEPC, driving proliferation and metastasis through effects on CBX2 and FOXA2. This indicates that LINC00261 may be utilized as a therapeutic target and a biomarker for NEPC.
MOLECULAR ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
B. Zhou, T. R. Stueve, E. A. Mihalakakos, L. Miao, D. Mullen, Y. Wang, Y. Liu, J. Luo, E. Tran, K. D. Siegmund, S. K. Lynch, A. L. Ryan, I. A. Offringa, Z. Borok, C. N. Marconett
Summary: This study comprehensively profiles the epigenomic alterations in enhancer regions during AEC differentiation, and reveals that the differentiation process is regulated by dynamic networks of transcription factors acting in concert, rather than individually. The findings provide insight into the relationship between disruption of the epigenetic state during AEC differentiation and development of lung diseases, potentially offering therapeutic strategies.
Editorial Material
Genetics & Heredity
Laurence St. Pierre, Crystal N. Marconett
Article
Environmental Sciences
Candace Johnson, Daniel J. Mullen, Suhaida A. Selamat, Mihaela Campan, Ite A. Offringa, Crystal N. Marconett
Summary: Lung cancer, mainly caused by tobacco exposure, is the leading cause of cancer-related death. The SULT1C2 gene is associated with lung adenocarcinoma (LUAD) patient survival and its expression is elevated in LUAD tumors. The study also found that the DNA methylation state of the SULT1C2 promoter is inversely correlated with expression in LUAD and varies depending on the race of the patient.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Evelyn Tran, Tuo Shi, Xiuwen Li, Adnan Y. Chowdhury, Du Jiang, Yixin Liu, Hongjun Wang, Chunli Yan, William D. Wallace, Rong Lu, Amy L. Ryan, Crystal N. Marconett, Beiyun Zhou, Zea Borok, Ite A. Offringa
Summary: In this study, we successfully established alveolar epithelial cell lines using de-identified human remnant transplant lungs. These cell lines were validated in both 2D and 3D cultures. In 3D culture, the cells formed alveolar-like organoids and expressed mature alveolar epithelial cell markers. Single-cell RNA sequencing revealed increased cellular heterogeneity and induction of cytokine and lipoprotein signaling in the 3D organoids.
Article
Cell Biology
Qian Zhong, Yixin Liu, Michele Ramos Correa, Crystal Nicole Marconett, Parviz Minoo, Changgong Li, David K. Ann, Beiyun Zhou, Zea Borok
Summary: NKX2.1 and FOXO1 have significant interactions in regulating specific gene expression and cell fate in the distal lung, with FOXO1 playing a central role in alveolar epithelial cell differentiation and maintaining homeostasis.
Article
Cell Biology
Minxiao Yang, Hua Shen, Per Flodby, Michael D. Koss, Rania Bassiouni, Yixin Liu, Tea Jashashvili, Aaron Neely, Ezuka Ogbolu, Jonathan Castillo, Theresa Ryan Stueve, Daniel J. Mullen, Amy L. Ryan, John Carpten, Alessandra Castaldi, W. Dean Wallace, Beiyun Zhou, Zea Borok, Crystal N. Marconett
Summary: Gramd2+ AT1 cells can serve as a cell of origin for a subtype of lung adenocarcinoma (LUAD), suggesting the importance of considering distinct subtypes based on cell of origin in the development of therapeutics.
Article
Cell Biology
Masafumi Horie, Alessandra Castaldi, Mitsuhiro Sunohara, Hongjun Wang, Yanbin Ji, Yixin Liu, Fan Li, Thomas A. Wilkinson, Long Hung, Hua Shen, Hidenori Kage, Ite A. Offringa, Crystal N. Marconett, Per Flodby, Beiyun Zhou, Zea Borok