Review
Biochemistry & Molecular Biology
Ioanna Akrida, Vasiliki Bravou, Helen Papadaki
Summary: The Hippo signaling pathway is essential for regulating organ size growth and tissue regeneration, and its dysfunction is implicated in cancer progression, particularly by promoting cell proliferation and EMT.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Food Science & Technology
Yuting Hao, Dongliang Feng, Huarui Ye, Wenzhen Liao
Summary: NOB can protect hepatocytes from undergoing EMT during liver fibrosis by inducing autophagy and subsequently modulating the Hippo/YAP pathway. Nobiletin significantly suppresses liver fibrosis in CCl4-induced mice and mitigates EMT in hepatocytes. Further investigation demonstrates that NOB can protect hepatocytes from undergoing EMT during liver fibrosis by regulating autophagy and the Hippo/YAP pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xin Wang, Jie Lu, Jing Li, Yang Liu, Gaochao Guo, Qiang Huang
Summary: Recent studies have shown that the IKBKE inhibitor CYT387 suppresses glioblastoma cell proliferation, migration, invasion and induces cell apoptosis and cell cycle arrest. Additionally, CYT387 activates the Hippo pathway and reduces IKBKE protein expression. Studies have also suggested that CYT387 has potential as a new antiglioblastoma drug, but further research is needed to address its limited ability to penetrate the blood-brain barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Isabele Cristiana Iser, Samlai Vedovatto, Fernanda Dittrich Oliveira, Liziane Raquel Beckenkamp, Guido Lenz, Marcia Rosangela Wink
Summary: Epithelial-mesenchymal transition (EMT) plays a crucial role in tumor progression, invasion, metastasis, therapy resistance, and poor prognosis in various types of cancer. Recent studies have identified a link between the CD73 enzyme and the EMT process. CD73 not only produces the immune suppressant adenosine (ADO), but also acts as a receptor for extracellular matrix proteins, contributing to cell adhesion and migration. The interaction between the adenosinergic pathway and the EMT program significantly impacts cancer development and progression. Analysis of RNAseq datasets reveals a significant correlation between EMT scores and the expressions of NT5E (CD73) and ENTPD1 (CD39) in multiple tumor types, with the strongest correlation observed in prostate adenocarcinoma. The cooperation between EMT and the adenosinergic pathway is context and tumor-dependent. Advancing knowledge in this area will facilitate the exploration of novel treatments and therapies for different types of cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Azar Abbas, Peng Jun, Jiang Yuan Yuan, Li Sun, Jinwei Jiang, Shengtao Yuan
Summary: This study provides evidence that GPR160 is a potential therapeutic target in glioma for the first time. These findings can be used to discover in detail the molecular mechanism and pathways through which GPR160 promotes glioma progression.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sara Lovisa
Summary: EMT, a process crucial in wound healing, fibrosis, and cancer, has gained significant attention from researchers since its discovery in the seventies. Despite advances in understanding its functional role, targeting EMT in fibrotic diseases remains a challenge at an early stage of development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Huizhi Wang, Yuntao Ding, Qiuming Zhu, Zhengyue Yu, Qi Wang, Aihua Gong, Min Xu
Summary: In this study, it was found that lncRNA FAM83A-AS1 is highly expressed in pancreatic cancer and is associated with poor prognosis. FAM83A-AS1 promotes epithelial-mesenchymal transition (EMT) of pancreatic cancer cells through activation of the Hippo pathway. Therefore, FAM83A-AS1 may serve as a potential diagnostic and prognostic target for pancreatic cancer.
Review
Biochemistry & Molecular Biology
Joanna Kozak, Alicja Forma, Marcin Czeczelewski, Pawel Kozyra, Elzbieta Sitarz, Elzbieta Radzikowska-Buchner, Monika Sitarz, Jacek Baj
Summary: Epithelial-mesenchymal transition (EMT) is a key process in the development of gastric cancer, affecting patient outcomes. There is an urgent need for research on pharmacological agents targeting EMT to prevent progression and potential metastasis of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hao Yu, Xueqing Hu, Yingru Zhang, Jiajia Wang, Zhongya Ni, Yan Wang, Huirong Zhu
Summary: Cancer metastasis is a major cause of death in cancer patients, and epithelial-mesenchymal transition (EMT) plays a crucial role in this process. Abnormal expression of Glycine Decarboxylase (GLDC) has been found in tumor progression, and GLDC is up-regulated in various types of cancers. However, the role of GLDC in colorectal cancer (CRC) metastasis is not well understood. This study aimed to investigate the role of GLDC in CRC metastasis and found that GLDC promotes EMT through the Hippo signaling pathway, providing a potential therapeutic target for CRC metastasis.
Review
Biochemistry & Molecular Biology
Lili Liang, Andreas M. Kaufmann
Summary: Cancer stem cells (CSCs) have been identified and characterized in both hematopoietic and solid tumors. They possess unique properties, including slow proliferation, self-renewal, differentiation, and the ability to undergo epithelial-mesenchymal transition (EMT) and its reverse process. CSCs play a crucial role in tumor growth, therapy resistance, and cancer metastasis. Strategies targeting CSCs are being developed for novel anti-metastasis treatments, aiming to improve therapeutic efficiency and prognosis with fewer side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Sarthak Sahoo, Sonali Priyadarshini Nayak, Kishore Hari, Prithu Purkait, Susmita Mandal, Akash Kishore, Herbert Levine, Mohit Kumar Jolly
Summary: Recent research shows that cells with hybrid epithelial/mesenchymal characteristics can have high levels of PD-L1, important for immune evasion, without needing to fully undergo epithelial-mesenchymal transition. This cellular state in breast cancer is associated with resistance to anti-estrogen therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
Article
Medicine, Research & Experimental
Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang, Xiangbo Xu
Summary: The study revealed that the overexpression of CHN1 is associated with lymph node metastasis and low survival rates in cervical carcinoma patients. CHN1 overexpression promoted cell proliferation, migration, and invasion by inducing EMT-related transcription factors. Furthermore, in vitro experiments showed that CHN1 overexpression activated the Akt/GSK-3 beta/Snail signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Ying Yang, Jin Wang, Fei Shi, Aijun Shan, Shihai Xu, Wen Lv
Summary: BDKRB2 expression in glioma is positively correlated with tumor grade, specifically in the more aggressive IDH wildtype and mesenchymal subtype tumors. It is significantly associated with EMT process, particularly with key biomarkers, and is an independent prognostic indicator for glioma patients.
Article
Cell & Tissue Engineering
Bing-zhou Xue, Wei Xiang, Qing Zhang, Hao-fei Wang, Yu-jie Zhou, Han Tian, Ahmed Abdelmaksou, Jian Xue, Min-xuan Sun, Dong-ye Yi, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao, Peng Fu
Summary: The study found that CD90(low) gaMSCs increased FOXS1 expression in glioma cells by secreting IL-6, leading to the activation of epithelial-mesenchymal transition and resistance to TMZ in these cells. These results reveal a new role of gaMSCs in promoting chemotherapy resistance.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Yang Liu, Jie Lu, Zhimeng Zhang, Lin Zhu, Shicai Dong, Gaochao Guo, Ruohong Li, Yang Nan, Kai Yu, Yue Zhong, Qiang Huang
CELL DEATH & DISEASE
(2017)
Article
Biotechnology & Applied Microbiology
Yang Nan, Hongbao Guo, Liyun Guo, Le Wang, Bingcheng Ren, Kai Yu, Qiang Huang, Yue Zhong
HUMAN GENE THERAPY CLINICAL DEVELOPMENT
(2018)
Article
Cell Biology
Yingwei Zhen, Yang Nan, Shewei Guo, Longzhou Zhang, Ge Li, Saichao Yue, Xianzhi Liu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Oncology
G. Guo, Y. Sun, R. Hong, J. Xiong, Y. Lu, Y. Liu, J. Lu, Z. Zhang, C. Guo, Y. Nan, Q. Huang
CLINICAL & TRANSLATIONAL ONCOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Jinbiao Xiong, Gaochao Guo, Lianmei Guo, Zengguang Wang, Zhijuan Chen, Yang Nan, Yiyao Cao, Ruilong Li, Xuejun Yang, Jun Dong, Xun Jin, Weidong Yang, Qiang Huang
Summary: The combined treatment with TMZ and amlexanox showed significant efficacy in inducing apoptosis and inhibiting cell viability, migration, and invasion in GBM cells. It also reversed the activation of Akt induced by TMZ and inhibited mTOR phosphorylation, potentially improving the prognosis of glioblastoma patients.
Article
Oncology
Bingcheng Ren, Le Wang, Yang Nan, Tong Liu, Liwen Zhao, Haiwen Ma, Jiabo Li, Yiming Zhang, Xiao Ren
Summary: The study revealed that RAB1A is highly expressed in gliomas, and patients with high RAB1A expression have significantly shortened overall survival time. Downregulation of RAB1A can inhibit the proliferation and invasion of glioma cells.
Article
Oncology
Yalin Lu, Gaochao Guo, Rujun Hong, Xingjie Chen, Yan Sun, Fang Liu, Zhimeng Zhang, Xun Jin, Jun Dong, Kai Yu, Xuejun Yang, Yang Nan, Qiang Huang
Summary: In this study, it was found that lncRNA HAS2-AS1 is upregulated in GBM cell lines and predominantly localized in the cytoplasm. High expression of HAS2-AS1 in vitro promoted proliferation, while knockdown of HAS2-AS1 significantly inhibited proliferation. Additionally, HAS2-AS1 acted as a ceRNA for miR-137, leading to the derepression of its downstream target LSD1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yang Nan, Liyun Guo, Yalin Lu, Gaochao Guo, Rujun Hong, Liwen Zhao, Le Wang, Bingcheng Ren, Kai Yu, Yue Zhong, Qiang Huang
Summary: miRNA-451 inhibits the PI3K/Akt/Snail signaling pathway by targeting CAB39, reducing proliferation, invasion, migration, and EMT of glioma cells, potentially serving as a new target for glioma treatment.
Article
Oncology
Xingjie Chen, Yalin Lu, Gaochao Guo, Yu Zhang, Yan Sun, Lianmei Guo, Ruohong Li, Yang Nan, Xuejun Yang, Jun Dong, Xun Jin, Qiang Huang
Summary: AMOTL2 is downregulated in high-grade glioma cells and can inhibit glioma proliferation, migration, and invasion by regulating beta-catenin nuclear localization, leading to a higher survival rate for patients with glioma.
Article
Medicine, Research & Experimental
Luqing Tong, Jiabo Li, Qiuying Li, Xuya Wang, Ravi Medikonda, Tianna Zhao, Tao Li, Haiwen Ma, Li Yi, Peidong Liu, Yang Xie, John Choi, Shengping Yu, Yu Lin, Jun Dong, Qiang Huang, Xun Jin, Michael Lim, Xuejun Yang