Article
Biotechnology & Applied Microbiology
Li Dong, Yumin Zheng, Xiaoguang Luo
Summary: This study focused on exploring the role of NEAT1 in Parkinson's disease (PD) and its effects on PD and related molecular mechanisms. The results showed that NEAT1 was involved in the development of PD, regulating cellular proliferation, apoptosis, and autophagy. Interfering with NEAT1 had potential therapeutic effects on PD by increasing the level of miR-107-5p.
Article
Neurosciences
Jiakai Chen, Handong Wang, Junjun Wang, Wenhao Niu, Chulei Deng, Mengliang Zhou
Summary: Accumulated evidence suggests that NEAT1 promotes glioma progression by acting as a sponge for miR-128-3p. The NEAT1/miR-128-3p/ITGA5 axis is involved in glioma initiation and progression, offering a potential novel strategy for treatment. NEAT1 competitively binds to miR-128-3p to enhance ITGA5 expression, activating the FAK signaling pathway and promoting cell growth in glioma.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Heng Yu, Anchun Xu, Bo Wu, Meng Wang, Zhongjun Chen
Summary: NEAT1 promotes glioma tumorigenesis by acting as a competing endogenous RNA for miR-185-5p to regulate DNMT1/mTOR signaling pathway, inhibiting apoptosis and promoting glioma migration, proliferation, and epithelial-mesenchymal transition. Moreover, NEAT1 knockdown can suppress tumor growth and alter the expression of related genes in vivo, highlighting its potential as a diagnostic and therapeutic target in glioma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jingshan Liang, Changtao Liu, Dezhi Xu, Kang Xie, Aimin Li
Summary: This study found that the long noncoding RNA NEAT1 promotes glioma progression by stabilizing PGK1. Overexpression of NEAT1 is associated with poor overall survival in GBM patients, indicating that the NEAT1/PGK1 axis may be a candidate therapeutic target for glioma treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Retraction
Cell Biology
Jianfei Tu, Zhongwei Zhao, Min Xu, Minjiang Chen, Qiaoyou Weng, Jiangmei Wang, Jiansong Ji
Summary: This article investigated the role of LINC00707 in the progression of hepatocellular carcinoma, revealing its contribution in promoting cancer progression by sponging miR-206 and increasing the expression of CDK14. However, following allegations raised by a third party and a detailed investigation, it was discovered that image elements of the experimental data had already been published elsewhere in a different scientific context. Therefore, the conclusions of this article are considered invalid.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Jun Liu, Jianwen Zhao, Guang Feng, Rui Li, Jianhang Jiao
Summary: This study explores the role of circ-CDK14 in the progression of osteosarcoma. The results show that silencing circ-CDK14 can inhibit proliferation, migration, and invasion of osteosarcoma cells and promote apoptosis. In addition, circ-CDK14 regulates the progression of osteosarcoma cells by targeting the miR-198/E2F2 axis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Jinpeng Hu, Guoqing Zhang, Yongfeng Wang, Kai Xu, Lian Chen, Gang Luo, Jinkun Xu, Hao Li, Dongmei Pei, Xiang Zhao, Zhengting Guo, Xinqiao Li, Shengliang Zong, Yang Jiang, Zhitao Jing
Summary: This study identifies a novel circular RNA, circGNB1, which is upregulated in glioma and closely associated with poor prognosis. Functional assays reveal that circGNB1 overexpression promotes the viability, proliferation, invasion, and neurosphere formation of glioma stem cells. Mechanistically, circGNB1 upregulates the expression of oncogene XPR1 by sponging miR-515-5p and miR-582-3p. XPR1, in turn, promotes the malignant phenotype of glioma stem cells through upregulating IL6 expression and activating JAK2/STAT3 signaling. Additionally, the RNA binding protein IGF2BP3 binds to and stabilizes circGNB1, thus enhancing its effects on glioma stem cells. This study uncovers the crucial role of circGNB1 in tumorigenesis and malignant progression of glioma, providing a promising cancer biomarker.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Guanghan Fan, Chenzhi Zhang, Xuyong Wei, Rongli Wei, Zhetuo Qi, Kangchen Chen, Xuechun Cai, Li Xu, Linsong Tang, Junbin Zhou, Zhensheng Zhang, Zuyuan Lin, Haiyang Xie, Shusen Zheng, Weimin Fan, Xiao Xu
Summary: This study investigates the mechanism of rapamycin-induced dyslipidemia after liver transplantation by focusing on the role of microRNA hsa-miR-372?3p in regulating triglyceride metabolism through target genes AGPS and APOC4. The results suggest that the NEAT1/hsa-miR-372?3p/AGPS/APOC4 axis plays a crucial role in disrupting lipid homeostasis caused by rapamycin, providing a potential therapeutic target for combating dyslipidemia post-LT.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jingjing Cui, Jian Wang, Yeke Lv, Dong Xu
Summary: The study found that the expression of lncRNA NEAT1 was up-regulated in the serum of infantile pneumonia patients, while miR-146b was down-regulated. Knocking down lncRNA NEAT1 promoted cell growth and reduced apoptosis, while over-expressing miR-146b enhanced cell viability. This study demonstrated that lncRNA NEAT1 regulates infantile pneumonia by sponging miR-146b.
MOLECULAR BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang Wei, Shan Xu, Liang Chen
Summary: Sevoflurane exacerbates neurotoxicity by inhibiting cell viability and promoting cell apoptosis, neuroinflammation, and ROS production. Neat1 is up-regulated in sevoflurane-treated cells, and its knockdown can improve sevoflurane-induced neurotoxicity. Through a ceRNA mechanism, it was found that Neat1 interacts with miR-298-5p to up-regulate Srpk1, ultimately contributing to sevoflurane-stimulated neurotoxicity.
NEUROCHEMICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Qunsheng Yan, Qingqing Hu, Guoxiang Li, Qiao Qi, Ziyan Song, Jie Shu, Hu Liang, Haoran Liu, Zongyao Hao
Summary: This study found that the lncRNA NEAT1 enhances IRF1 signaling through targeted repression of miR-130a-3p and activates the TLR4/NF-kappa B pathways, promoting oxidative damage during CaOx crystal deposition. This provides an explanation for tubular epithelial damage caused by CaOx crystals and offers new ideas and drug targets for the prevention and treatment of CaOx nephrocalcinosis.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Oncology
Hai-Yan Piao, Yang Liu, Ye Kang, Yue Wang, Xiang-Yu Meng, Dong Yang, Jun Zhang
Summary: HYPAL is significantly upregulated in gastric cancer cells and tissues, correlating with poor prognosis, and activates the Wnt/β-catenin signaling pathway to promote gastric cancer cell proliferation. It may serve as a potential molecular target for gastric cancer therapy.
Article
Biochemistry & Molecular Biology
Ronald O. B. de Keizer, Anne L. M. Vriends, Gijsbert J. Hotte, Dion A. Paridaens, Erik A. C. Wiemer, Robert M. Verdijk
Summary: The study aims to find microRNA biomarkers to distinguish between Ocular Sebaceous Carcinoma (OSC) and Squamous Cell Carcinomas of the Conjunctiva (SCCC), as well as normal tissue. The combination of miR-196b-5p and miR-107 can be used as an additional diagnostic tool to differentiate OSC and SCCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xia Lv, Xiang-Yan Zhang, Qian Zhang, Ying-Jie Nie, Guang-Heng Luo, Xia Fan, Song Yang, Qing-Hua Zhao, Jian-Quan Li
Summary: The study reveals that NEAT1 plays a role in the inflammation and cell cycle progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Hongli Li, Yiwei Zhang, Huiqin Song, Li Li
Summary: The study revealed that circRFX3 functions as a tumor promoter in glioma by modulating the miR-1179/miR-1229-VASP axis, promoting cell proliferation, migration, and invasion while reducing apoptosis. These findings provide a new target and therapeutic strategy for glioma treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yuan Tian, Shaobo Hao, Minhua Ye, Anling Zhang, Yang Nan, Guangxiu Wang, Zhifan Jia, Kai Yu, Lianmei Guo, Peiyu Pu, Qiang Huang, Yue Zhong
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Oncology
Hongbao Guo, Yang Nan, Yingwei Zhen, Yahui Zhang, Liyun Guo, Kai Yu, Qiang Huang, Yue Zhong
Article
Oncology
Yang Nan, Liyun Guo, Yunpeng Song, Le Wang, Kai Yu, Qiang Huang, Yue Zhong
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2017)
Article
Oncology
Zhimeng Zhang, Jie Lu, Gaochao Guo, Yi Yang, Shicai Dong, Yang Liu, Yang Nan, Yue Zhong, Kai Yu, Qiang Huang
Article
Cell Biology
Yang Liu, Jie Lu, Zhimeng Zhang, Lin Zhu, Shicai Dong, Gaochao Guo, Ruohong Li, Yang Nan, Kai Yu, Yue Zhong, Qiang Huang
CELL DEATH & DISEASE
(2017)
Article
Oncology
Jie Lu, Yi Yang, Gaochao Guo, Yang Liu, Zhimeng Zhang, Shicai Dong, Yang Nan, Zhenyi Zhao, Yue Zhong, Qiang Huang
Article
Neurosciences
Yang Nan, Lei Han, Anling Zhang, Guangxiu Wang, Zhifan Jia, Yang Yang, Xiao Yue, Peiyu Pu, Yue Zhong, Chunsheng Kang
Article
Oncology
Yuan Tian, Yang Nan, Lei Han, Anling Zhang, Guangxiu Wang, Zhifan Jia, Jianwei Hao, Peiyu Pu, Yue Zhong, Chunsheng Kang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Yang Nan, Hongbao Guo, Liyun Guo, Le Wang, Bingcheng Ren, Kai Yu, Qiang Huang, Yue Zhong
HUMAN GENE THERAPY CLINICAL DEVELOPMENT
(2018)
Article
Chemistry, Multidisciplinary
Jinbiao Xiong, Gaochao Guo, Lianmei Guo, Zengguang Wang, Zhijuan Chen, Yang Nan, Yiyao Cao, Ruilong Li, Xuejun Yang, Jun Dong, Xun Jin, Weidong Yang, Qiang Huang
Summary: The combined treatment with TMZ and amlexanox showed significant efficacy in inducing apoptosis and inhibiting cell viability, migration, and invasion in GBM cells. It also reversed the activation of Akt induced by TMZ and inhibited mTOR phosphorylation, potentially improving the prognosis of glioblastoma patients.
Article
Oncology
Bingcheng Ren, Le Wang, Yang Nan, Tong Liu, Liwen Zhao, Haiwen Ma, Jiabo Li, Yiming Zhang, Xiao Ren
Summary: The study revealed that RAB1A is highly expressed in gliomas, and patients with high RAB1A expression have significantly shortened overall survival time. Downregulation of RAB1A can inhibit the proliferation and invasion of glioma cells.
Article
Oncology
Yalin Lu, Gaochao Guo, Rujun Hong, Xingjie Chen, Yan Sun, Fang Liu, Zhimeng Zhang, Xun Jin, Jun Dong, Kai Yu, Xuejun Yang, Yang Nan, Qiang Huang
Summary: In this study, it was found that lncRNA HAS2-AS1 is upregulated in GBM cell lines and predominantly localized in the cytoplasm. High expression of HAS2-AS1 in vitro promoted proliferation, while knockdown of HAS2-AS1 significantly inhibited proliferation. Additionally, HAS2-AS1 acted as a ceRNA for miR-137, leading to the derepression of its downstream target LSD1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yang Nan, Liyun Guo, Yalin Lu, Gaochao Guo, Rujun Hong, Liwen Zhao, Le Wang, Bingcheng Ren, Kai Yu, Yue Zhong, Qiang Huang
Summary: miRNA-451 inhibits the PI3K/Akt/Snail signaling pathway by targeting CAB39, reducing proliferation, invasion, migration, and EMT of glioma cells, potentially serving as a new target for glioma treatment.
Article
Oncology
Xingjie Chen, Yalin Lu, Gaochao Guo, Yu Zhang, Yan Sun, Lianmei Guo, Ruohong Li, Yang Nan, Xuejun Yang, Jun Dong, Xun Jin, Qiang Huang
Summary: AMOTL2 is downregulated in high-grade glioma cells and can inhibit glioma proliferation, migration, and invasion by regulating beta-catenin nuclear localization, leading to a higher survival rate for patients with glioma.
