Latest Developments in Metalloenzyme Design and Repurposing

Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

(2015) Hans Renata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

(2015) Gopeekrishnan Sreenilayam et al.   CHEMICAL COMMUNICATIONS

Transition-metal-mediated uncaging in living human cells—an emerging alternative to photolabile protecting groups

(2015) Timo Völker et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Artificial hydrogenases: biohybrid and supramolecular systems for catalytic hydrogen production or uptake

(2015) Giorgio Caserta et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Artificial hydrogenase: biomimetic approaches controlling active molecular catalysts

(2015) Akira Onoda et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Light-driven hydrogen production from Photosystem I-catalyst hybrids

(2015) Lisa M Utschig et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Approaches to the design of catalytic metallodrugs

(2015) Joan J Soldevila-Barreda et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids

(2015) Ivana Drienovská et al.   Chemical Science

Intermolecular carbene S–H insertion catalysed by engineered myoglobin-based catalysts

(2015) Vikas Tyagi et al.   Chemical Science

Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design

(2015) Joan J. Soldevila-Barreda et al.   Nature Communications

Enzymatic C(sp3)-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones

(2015) Ritesh Singh et al.   ACS Catalysis

A Genetically Encoded Alkyne Directs Palladium-Mediated Protein Labeling on Live Mammalian Cell Surface

(2014) Nan Li et al.   ACS Chemical Biology

Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran

(2014) Z. Jane Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

(2014) Timo Völker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Diastereoselective and Enantioselective Olefin Cyclopropanation Using Engineered Myoglobin-Based Catalysts

(2014) Melanie Bordeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Designing Hydrolytic Zinc Metalloenzymes

(2014) Melissa L. Zastrow et al.   BIOCHEMISTRY

Intramolecular C(sp3)H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts

(2014) Melanie Bordeaux et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Non-natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins

(2014) Thomas Heel et al.   CHEMBIOCHEM

An Artificial Imine Reductase based on the Ribonuclease S Scaffold

(2014) Maika Genz et al.   ChemCatChem

Protein Design: Toward Functional Metalloenzymes

(2014) Fangting Yu et al.   CHEMICAL REVIEWS

Hydrogenases

(2014) Wolfgang Lubitz et al.   CHEMICAL REVIEWS

Hybrid Ruthenium ROMP Catalysts Based on an Engineered Variant of β-Barrel Protein FhuA ΔCVFtev: Effect of Spacer Length

(2014) Daniel F. Sauer et al.   Chemistry-An Asian Journal

Neocarzinostatin-based hybrid biocatalysts for oxidation reactions

(2014) Elodie Sansiaume-Dagousset et al.   DALTON TRANSACTIONS

Cobaloxime-Based Artificial Hydrogenases

(2014) Marine Bacchi et al.   INORGANIC CHEMISTRY

P450BM3-Axial Mutations: A Gateway to Non-Natural Reactivity

(2014) Todd K. Hyster et al.   ISRAEL JOURNAL OF CHEMISTRY

Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination

(2014) Todd K. Hyster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct EPR Observation of a Tyrosyl Radical in a Functional Oxidase Model in Myoglobin during both H2O2 and O2 Reactions

(2014) Yang Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Systematic Tuning of Heme Redox Potentials and Its Effects on O2 Reduction Rates in a Designed Oxidase in Myoglobin

(2014) Ambika Bhagi-Damodaran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer

(2014) Christopher C. Farwell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neutralizing the Detrimental Effect of Glutathione on Precious Metal Catalysts

(2014) Yvonne M. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

(2014) Megan L Matthews et al.   Nature Chemical Biology

Short peptides self-assemble to produce catalytic amyloids

(2014) Caroline M. Rufo et al.   Nature Chemistry

A designed supramolecular protein assembly with in vivo enzymatic activity

(2014) Woon Ju Song et al.   SCIENCE

Functional tuning and expanding of myoglobin by rational protein design

(2014) YingWu Lin et al.   Science China-Chemistry

Manganese terpyridine artificial metalloenzymes for benzylic oxygenation and olefin epoxidation

(2014) Chen Zhang et al.   TETRAHEDRON

P450-Catalyzed Intramolecular sp3 C–H Amination with Arylsulfonyl Azide Substrates

(2014) Ritesh Singh et al.   ACS Catalysis

Photoinduced Hydrogen Evolution Catalyzed by a Synthetic Diiron Dithiolate Complex Embedded within a Protein Matrix

(2014) Akira Onoda et al.   ACS Catalysis

P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions

(2014) Hans Renata et al.   Catalysis Science & Technology

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

(2013) John A. McIntosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Method for Artificial Metalloenzyme Formation through Strain-Promoted Azide-Alkyne Cycloaddition

(2013) Hao Yang et al.   CHEMBIOCHEM

Electron Flow through Metalloproteins

(2013) Jay R. Winkler et al.   CHEMICAL REVIEWS

A Hybrid Ring-Opening Metathesis Polymerization Catalyst Based on an Engineered Variant of the β-Barrel Protein FhuA

(2013) Freddi Philippart et al.   CHEMISTRY-A EUROPEAN JOURNAL

Coupling Photocatalysis and Redox Biocatalysis Toward Biocatalyzed Artificial Photosynthesis

(2013) Sahng Ha Lee et al.   CHEMISTRY-A EUROPEAN JOURNAL

Olefin metathesis in aqueous media

(2013) Jasmine Tomasek et al.   GREEN CHEMISTRY

C(sp3)–H Bond Hydroxylation Catalyzed by Myoglobin Reconstituted with Manganese Porphycene

(2013) Koji Oohora et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Efficient Light-Driven P450 BM3 Biocatalyst

(2013) Ngoc-Han Tran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Delivery of a Ni Catalyst to Photosystem I for Light-Driven Hydrogen Production

(2013) Sunshine C. Silver et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

(2013) Shaun D. Wong et al.   NATURE

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

(2013) Pedro S Coelho et al.   Nature Chemical Biology

Spontaneous activation of [FeFe]-hydrogenases by an inorganic [2Fe] active site mimic

(2013) Julian Esselborn et al.   Nature Chemical Biology

Human carbonic anhydrase II as host protein for the creation of artificial metalloenzymes: the asymmetric transfer hydrogenation of imines

(2013) Fabien W. Monnard et al.   Chemical Science

An enantioselective artificial metallo-hydratase

(2013) Jeffrey Bos et al.   Chemical Science

Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds

(2013) Z. Jane Wang et al.   Chemical Science

Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis

(2013) Carl A. Denard et al.   ACS Catalysis

Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis

(2013) Jared C. Lewis   ACS Catalysis

Enantioselective Artificial Metalloenzymes by Creation of a Novel Active Site at the Protein Dimer Interface

(2012) Jeffrey Bos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Significant Increase of Oxidase Activity through the Genetic Incorporation of a Tyrosine-Histidine Cross-Link in a Myoglobin Model of Heme-Copper Oxidase

(2012) Xiaohong Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Designed Functional Metalloenzyme that Reduces O2 to H2O with Over One Thousand Turnovers

(2012) Kyle D. Miner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalysis by a De Novo Zinc-Mediated Protein Interface: Implications for Natural Enzyme Evolution and Rational Enzyme Engineering

(2012) Bryan S. Der et al.   BIOCHEMISTRY

A rhodium complex-linked β-barrel protein as a hybrid biocatalyst for phenylacetylene polymerization

(2012) Akira Onoda et al.   CHEMICAL COMMUNICATIONS

Semi-synthesis of an artificial scandium(iii) enzyme with a β-helical bio-nanotube

(2012) Hiroshi Inaba et al.   DALTON TRANSACTIONS

ATP-Uncoupled, Six-Electron Photoreduction of Hydrogen Cyanide to Methane by the Molybdenum–Iron Protein

(2012) Lauren E. Roth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

(2012) Sagar D Khare et al.   Nature Chemical Biology

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

(2012) V. Köhler et al.   Nature Chemistry

pH-tuned metal coordination and peroxidase activity of a peptide dendrimer enzyme model with a Fe(ii)bipyridine at its core

(2012) Piero Geotti-Bianchini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

(2012) P. S. Coelho et al.   SCIENCE

Incorporation of Manganese Complexes into Xylanase: New Artificial Metalloenzymes for Enantioselective Epoxidation

(2011) Mathieu Allard et al.   CHEMBIOCHEM

Light-Driven Uncoupling of Nitrogenase Catalysis from ATP Hydrolysis

(2011) Lauren E. Roth et al.   ChemCatChem

Artificial metalloenzymes for olefin metathesis based on the biotin-(strept)avidin technology

(2011) Cheikh Lo et al.   CHEMICAL COMMUNICATIONS

An artificial metalloenzyme for olefin metathesis

(2011) Clemens Mayer et al.   CHEMICAL COMMUNICATIONS

Creation of an artificial metalloprotein with a Hoveyda–Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin

(2011) Takashi Matsuo et al.   CHEMICAL COMMUNICATIONS

Preparation and reactivity of a tetranuclear Fe(II) core in the metallothionein α-domain

(2011) Yohei Sano et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Photocatalytic hydrogen evolution by a diiron hydrogenase model based on a peptide fragment of cytochrome c556 with an attached diiron carbonyl cluster and an attached ruthenium photosensitizer

(2011) Yohei Sano et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Palladium-mediated intracellular chemistry

(2011) Rahimi M. Yusop et al.   Nature Chemistry

Hydrolytic catalysis and structural stabilization in a designed metalloprotein

(2011) Melissa L. Zastrow et al.   Nature Chemistry

Heme proteins-Diversity in structural characteristics, function, and folding

(2010) Lorna J. Smith et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Rational design of a structural and functional nitric oxide reductase

(2009) Natasha Yeung et al.   NATURE

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of a Site-Specific DNA Cleaving Protein

(2008) Hyun Soo Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric catalytic cyclopropanation reactions in water

(2007) Irène Nicolas et al.   COORDINATION CHEMISTRY REVIEWS