The Relationship between Fatty Acids and Different Depression-Related Brain Regions, and Their Potential Role as Biomarkers of Response to Antidepressants

Long-Chain Polyunsaturated Fatty Acids Modulate Interleukin-1β–Induced Changes in Behavior, Monoaminergic Neurotransmitters, and Brain Inflammation in Rats

(2018) Cai Song et al.   JOURNAL OF NUTRITION

Plasma lipidomics reveals potential lipid markers of major depressive disorder

(2016) Xinyu Liu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Maternal diet of polyunsaturated fatty acid altered the cell proliferation in the dentate gyrus of hippocampus and influenced glutamatergic and serotoninergic systems of neonatal female rats

(2016) Mimi Tang et al.   Lipids in Health and Disease

Fruit and vegetable consumption and the risk of depression: A meta-analysis

(2016) Xiaoqin Liu et al.   NUTRITION

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

(2016) Artemis Simopoulos   Nutrients

Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder

(2016) R J T Mocking et al.   Translational Psychiatry

Brain membrane lipids in major depression and anxiety disorders

(2015) Christian P. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Western diet is associated with a smaller hippocampus: a longitudinal investigation

(2015) Felice N. Jacka et al.   BMC Medicine

Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers

(2015) Chika Horikawa et al.   BRITISH JOURNAL OF NUTRITION

Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker

(2015) Robert K. McNamara et al.   Early Intervention in Psychiatry

A review of recent evidence in human studies of n-3 and n-6 PUFA intake on cardiovascular disease, cancer, and depressive disorders: does the ratio really matter?

(2015) Stefano Marventano et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids

(2015) Cecile Hryhorczuk et al.   NEUROPSYCHOPHARMACOLOGY

Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression

(2015) Lin Ge et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice

(2015) F. Guida et al.   Molecular Brain

Dietary patterns and the risk of depression in adults: a systematic review of observational studies

(2014) Corinna Rahe et al.   EUROPEAN JOURNAL OF NUTRITION

Effects of omega-3 on behavioral and biochemical parameters in rats submitted to chronic mild stress

(2014) Aline Haas de Mello et al.   METABOLIC BRAIN DISEASE

Linoleic Acid Derivative DCP-LA Ameliorates Stress-Induced Depression-Related Behavior by Promoting Cell Surface 5-HT1A Receptor Translocation, Stimulating Serotonin Release, and Inactivating GSK-3β

(2014) Takeshi Kanno et al.   MOLECULAR NEUROBIOLOGY

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms

(2014) Giuseppe Grosso et al.   Oxidative Medicine and Cellular Longevity

Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials

(2014) Giuseppe Grosso et al.   PLoS One

A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults

(2013) Jun S Lai et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis

(2013) Theodora Psaltopoulou et al.   ANNALS OF NEUROLOGY

The Epidemiology of Depression Across Cultures

(2013) Ronald C. Kessler et al.   Annual Review of Public Health

N-3 (Omega-3) Polyunsaturated Fatty Acids in the Pathophysiology and Treatment of Depression: Pre-Clinical Evidence

(2013) Beth Levant   CNS & Neurological Disorders-Drug Targets

Biomarkers Predicting Antidepressant Treatment Response: How Can We Advance the Field?

(2013) Christiana Labermaier et al.   DISEASE MARKERS

Omega-6 fatty acids and greater likelihood of suicide risk and major depression in early pregnancy

(2013) Juliana S. Vaz et al.   JOURNAL OF AFFECTIVE DISORDERS

Striatum-Based Circuitry of Adolescent Depression and Anhedonia

(2013) Vilma Gabbay et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Prolonged High Fat Diet Reduces Dopamine Reuptake without Altering DAT Gene Expression

(2013) Jackson J. Cone et al.   PLoS One

Abnormalities in the fatty acid composition of the postmortem entorhinal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder

(2013) Kei Hamazaki et al.   PSYCHIATRY RESEARCH

Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice

(2013) Melissa M. Kaczmarczyk et al.   PSYCHONEUROENDOCRINOLOGY

Relationship between the hypothalamic–pituitary–adrenal-axis and fatty acid metabolism in recurrent depression

(2013) Roel J.T. Mocking et al.   PSYCHONEUROENDOCRINOLOGY

Fatty Acid Modulation of the Endocannabinoid System and the Effect on Food Intake and Metabolism

(2013) Shaan S. Naughton et al.   International Journal of Endocrinology

Fatting the brain: a brief of recent research

(2013) Ghulam Hussain et al.   Frontiers in Cellular Neuroscience

Maternal high-fat diet in mice programs emotional behavior in adulthood

(2012) Daria Peleg-Raibstein et al.   BEHAVIOURAL BRAIN RESEARCH

Fatty acid composition of membrane bilayers: Importance of diet polyunsaturated fat balance

(2012) Sarah K. Abbott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population – A preliminary study

(2012) Hirohito Tsuboi et al.   CLINICAL NUTRITION

Monounsaturated Fatty Acids Prevent the Aversive Effects of Obesity on Locomotion, Brain Activity, and Sleep Behavior

(2012) T. Sartorius et al.   DIABETES

Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry

(2012) S Sharma et al.   INTERNATIONAL JOURNAL OF OBESITY

Saturated long-chain fatty acids activate inflammatory signaling in astrocytes

(2012) Sunita Gupta et al.   JOURNAL OF NEUROCHEMISTRY

Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic–pituitary–adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life

(2012) Hui-Feng Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice

(2012) Thomas Larrieu et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation

(2012) Umashankar Vetrivel et al.   Lipids in Health and Disease

Where in the Brain Is Depression?

(2012) Mayur Pandya et al.   Current Psychiatry Reports

High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour

(2012) Sandeep Sharma et al.   Scientific Reports

Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons

(2011) Laura J. Fick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Omega-3 Fatty Acid Augmentation of Citalopram Treatment for Patients With Major Depressive Disorder

(2011) Lev Gertsik et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain

(2011) Artemis P. Simopoulos   MOLECULAR NEUROBIOLOGY

Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions

(2011) Mathieu Lafourcade et al.   NATURE NEUROSCIENCE

Dietary Fat Intake and the Risk of Depression: The SUN Project

(2011) Almudena Sánchez-Villegas et al.   PLoS One

Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission

(2011) Stanley I. Rapoport et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Fatty acid transport into the brain: Of fatty acid fables and lipid tails

(2011) Ryan W. Mitchell et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment

(2011) Bun-Hee Lee et al.   Psychiatry Investigation

Behavioural effects of a 10-day Mediterranean diet. Results from a pilot study evaluating mood and cognitive performance

(2010) Laura McMillan et al.   APPETITE

A Meta-Analytic Review of Polyunsaturated Fatty Acid Compositions in Patients with Depression

(2010) Pao-Yen Lin et al.   BIOLOGICAL PSYCHIATRY

Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder

(2010) Robert K. McNamara et al.   JOURNAL OF AFFECTIVE DISORDERS

The Efficacy of Omega-3 Supplementation for Major Depression

(2010) François Lespérance et al.   JOURNAL OF CLINICAL PSYCHIATRY

Chronic Consumption of a High-Fat Diet during Pregnancy Causes Perturbations in the Serotonergic System and Increased Anxiety-Like Behavior in Nonhuman Primate Offspring

(2010) E. L. Sullivan et al.   JOURNAL OF NEUROSCIENCE

DHA Deficiency and Prefrontal Cortex Neuropathology in Recurrent Affective Disorders

(2010) Robert K. McNamara   JOURNAL OF NUTRITION

Phospholipid profile in the postmortem hippocampus of patients with schizophrenia and bipolar disorder: No changes in docosahexaenoic acid species

(2010) Kei Hamazaki et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity

(2010) Daisuke Miyazawa et al.   LIFE SCIENCES

Genetic Deletion of Fatty Acid Amide Hydrolase Alters Emotional Behavior and Serotonergic Transmission in the Dorsal Raphe, Prefrontal Cortex and Hippocampus

(2010) Francis Rodriguez Bambico et al.   NEUROPSYCHOPHARMACOLOGY

Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status

(2010) Paul F. Davis et al.   NUTRITIONAL NEUROSCIENCE

Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder

(2010) Shima Jazayeri et al.   PSYCHIATRY RESEARCH

Association of the Mediterranean Dietary Pattern With the Incidence of Depression

(2009) Almudena Sánchez-Villegas et al.   ARCHIVES OF GENERAL PSYCHIATRY

Olive Oils Modulate Fatty Acid Content and Signaling Protein Expression in Apolipoprotein E Knockout Mice Brain

(2009) Regina Alemany et al.   LIPIDS

Dietary linoleic and oleic fatty acids in relation to severe depressed mood: 10 years follow-up of a national cohort

(2009) Allen R. Wolfe et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress

(2009) Matthew N. Hill et al.   PSYCHONEUROENDOCRINOLOGY

Understanding nutrition, depression and mental illnesses

(2009) TS Sathyanarayana Rao et al.   Indian Journal of Psychiatry

Comparison of Therapeutic Effects of Omega-3 Fatty Acid Eicosapentaenoic Acid and Fluoxetine, Separately and in Combination, in Major Depressive Disorder

(2008) Shima Jazayeri et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine

(2008) Andreas Artmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hippocampal volume and 2-year outcome in depression

(2008) Klaus-Thomas Kronmüller et al.   BRITISH JOURNAL OF PSYCHIATRY

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

(2008) Artemis P. Simopoulos   EXPERIMENTAL BIOLOGY AND MEDICINE

Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography

(2008) John C. Umhau et al.   JOURNAL OF LIPID RESEARCH

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

(2008) G. Esposito et al.   JOURNAL OF NUCLEAR MEDICINE

Long-Chain Omega-3 Polyunsaturated Fatty Acids in the Blood of Children and Adolescents with Juvenile Bipolar Disorder

(2008) Edward H. Clayton et al.   LIPIDS

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Brain foods: the effects of nutrients on brain function

(2008) Fernando Gómez-Pinilla   NATURE REVIEWS NEUROSCIENCE

Corticosteroid–serotonin interactions in the neurobiological mechanisms of stress-related disorders

(2008) Laurence Lanfumey et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report

(2008) M. Hill et al.   PHARMACOPSYCHIATRY

Synergistic effects of stress and omega-3 fatty acid deprivation on emotional response and brain lipid composition in adult rats

(2008) G. Mathieu et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults

(2007) Kentaro Murakami et al.   NUTRITION