HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways

17-DMAG targets the nuclear factor- B family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

(2010) E. Hertlein et al.   BLOOD

17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells

(2010) Panagiotis K Karkoulis et al.   BMC CANCER

Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis

(2010) Julio Madrigal-Matute et al.   CARDIOVASCULAR RESEARCH

Heat shock protein 90 regulates IκB kinase complex and NF-κB activation in angiotensin II-induced cardiac cell hypertrophy

(2010) Kyung Hye Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

An NF-κB–Dependent Role for JunB in the Induction of Proinflammatory Cytokines in LPS-Activated Bone Marrow–Derived Dendritic Cells

(2010) Tiphanie Gomard et al.   PLoS One

Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70

(2010) M. Howard et al.   THORAX

Hsp90: A Drug Target?

(2010) Jeffrey M. Holzbeierlein et al.   Current Oncology Reports

Expression of interleukin-6 is downregulated by 17-(allylamino)-17-demethoxygeldanamycin in human prostatic carcinoma cells

(2009) Ke-hung Tsui et al.   ACTA PHARMACOLOGICA SINICA

The biology of reactive intermediates in systemic lupus erythematosus

(2009) Jim C. Oates   AUTOIMMUNITY

Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity

(2009) Sampa Ghoshal et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?

(2009) A. Graham Pockley et al.   CELL STRESS & CHAPERONES

Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex

(2009) Christina B. Clark et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Toll-like receptor mediated signaling pathway in ischemic heart

(2009) Yasuchika Takeishi   Frontiers in Bioscience-Landmark

Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma

(2009) O. Ayrault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geldanamycin Analog 17-DMAG Inhibits iNOS and Caspases in Gamma-Irradiated Human T Cells

(2009) Juliann G. Kiang et al.   RADIATION RESEARCH

The AKT Axis as a Therapeutic Target in Autoimmune Diseases

(2009) Tianfu Wu et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction

(2008) Sumathy Mohan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas

(2008) Jeremy S. Abramson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism

(2008) T. Ha et al.   CARDIOVASCULAR RESEARCH

Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects

(2008) Petrus R. de Jong et al.   CELL STRESS & CHAPERONES

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

IFN-γ synergizes with LPS to induce nitric oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10

(2008) Chiou-Feng Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-α regulation

(2008) Pranoti Mandrekar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dominant-Negative Hsp90 Reduces VEGF-Stimulated Nitric Oxide Release and Migration in Endothelial Cells

(2007) Robert Q. Miao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY