Review
Biochemistry & Molecular Biology
Mariusz A. Bromke, Malgorzata Krzystek-Korpacka
Summary: Inflammatory bowel disease, characterized by chronic and complex conditions such as ulcerative colitis or Crohn's disease, is closely linked to dysregulation of the mucosal immune system, compromised intestinal epithelial barrier, and dysbiosis of the gut microbiome. Bile acids play a significant physiological role beyond aiding digestion of lipids, acting as signaling molecules on lipid metabolism and immune responses through various receptors. Recent studies have focused on the therapeutic potential of bile acids in the treatment of inflammatory bowel disease, highlighting their impact on gut microbiome and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Veronika Wess, Paula Schuster-Winkelmann, Yasemin Hazal Karatekin, Simge Malik, Florian Beigel, Florian Kuehn, Roswitha Gropp
Summary: Animal models, such as NSG-UC and NSG-CD mice, can partially mimic the pathologies of ulcerative colitis (UC) and Crohn's disease (CD) in humans. NSG-UC mice exhibit a strong inflammatory response when challenged with ethanol, while NSG-CD mice develop pathological manifestations without challenge.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Magdalena Kurnik-Lucka, Pawel Pasieka, Patrycja Laczak, Marcin Wojnarski, Michal Jurczyk, Krzysztof Gil
Summary: The dopaminergic system may play a significant role in inflammatory bowel disease, but its impact is currently underestimated. Further in-depth observational studies are needed to support this notion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Xiaowen Zheng, Yi Zhu, Zihan Zhao, Ying Chu, Wenjing Yang
Summary: Inflammation is a characteristic symptom of many diseases, and this review summarizes the changes and mechanisms of amino acids in inflammatory bowel disease and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ines Silva, Joao Solas, Rui Pinto, Vanessa Mateus
Summary: This study successfully developed and validated a chronic TNBS-induced colitis mouse model. After week 4, clinical and inflammation signs remained stable, suggesting the model develops within 4 weeks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Bartolo Tamburini, Marco Pio La Manna, Lidia La Barbera, Leila Mohammadnezhad, Giusto Davide Badami, Mojtaba Shekarkar Azgomi, Francesco Dieli, Nadia Caccamo
Summary: Inflammatory bowel disease (IBD) is a pressing global health problem with increasing incidence worldwide. While the exact etiology is still unclear, a complex interaction of factors, including immune system defects, microbial dysbiosis, genetic predisposition, and environmental factors, contribute to the development of inflammation. This review aims to analyze the intricate balance between these elements in maintaining intestinal homeostasis and preventing or minimizing the adverse effects of IBD on health.
Review
Biochemistry & Molecular Biology
Brunette Katsandegwaza, William Horsnell, Katherine Smith
Summary: This article reviews the current murine models used for studying human inflammatory bowel disease, including chemical-induced models, gene-deficient models, and cell transfer models. The application and limitations of these models in understanding the disease pathogenesis and developing new clinical treatment strategies are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Yun Ji, Ying Yang, Shiqiang Sun, Zhaolai Dai, Fazheng Ren, Zhenlong Wu
Summary: The incidence and prevalence of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, have been increasing substantially. Dietary factors, particularly those with high levels of saturated fat or sugar, have been found to be involved in the development and progression of IBD. The imbalance of gut microbiota exacerbates oxidative stress and inflammatory responses, leading to disturbances in intestinal redox balance and immunity. Recent studies have shown that functional amino acids play a crucial role in maintaining intestinal redox and immune homeostasis, as they have antioxidative and anti-inflammatory properties and can modulate the microbial community and metabolites in the gut.
Article
Medicine, General & Internal
Juan Manuel Medina, Raul Fernandez-Lopez, Javier Crespo, Fernando de la Cruz
Summary: Studies have found that genes related to propionate production in the gut microbiome are decreased in patients with Crohn's disease. Changes in overall species abundance may not necessarily correlate with changes in metabolic gene abundances, indicating that alterations in strain composition may be as important as changes in species abundance in pathological conditions associated with the gut microbiome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Jian He, Xiaobei Luo, Hongjie Xin, Qianwei Lai, Yuanping Zhou, Yang Bai
Summary: Omega-3 fatty acids have a protective effect against ulcerative colitis, while there is no causal relationship between other fatty acids and inflammatory bowel disease.
Review
Nutrition & Dietetics
Pandi He, Leilei Yu, Fengwei Tian, Hao Zhang, Wei Chen, Qixiao Zhai
Summary: Dietary patterns and the gut microbiota play significant roles in the occurrence and progression of inflammatory bowel disease (IBD). Dietary patterns can modulate IBD through various signaling pathways, while the gut microbiota affects IBD susceptibility genes, immune function, and physiological metabolism. The interplay between dietary patterns and the gut microbiota impacts the onset and progression of IBD.
ADVANCES IN NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Na Li, Shukai Zhan, Zhenyi Tian, Caiguang Liu, Zonglin Xie, Shenghong Zhang, Minhu Chen, Zhirong Zeng, Xiaojun Zhuang
Summary: Patients with inflammatory bowel disease (IBD) exhibit specific changes in bile acids (BAs), with an increase in primary and conjugated BAs and a decrease in secondary BAs in fecal samples. These changes may have profound effects on IBD patients by shaping the gut microbiota community, disrupting inflammatory processes, causing bile acid malabsorption associated with diarrhea, and potentially leading to intestinal dysplasia and cancer. Therapeutic strategies targeting the correction of BA composition alterations, such as the removal of excess BAs and supplementation of deficient BAs, show promise in the treatment of IBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Immunology
John P. Thomas, Dezso Modos, Simon M. Rushbrook, Nick Powell, Tamas Korcsmaros
Summary: This review examines the interaction between bile acid metabolites and intestinal inflammation in inflammatory bowel disease (IBD), highlighting their role in regulation of the inflammatory milieu through pathways such as autophagy, apoptosis, and the inflammasome pathway. The study also discusses the potential of novel experimental and bioinformatics approaches to further advance our understanding of the role of bile acids in IBD and inform therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nuha Mahmoud, Mohamed-Elamir F. Hegazy, Walaa Wadie, Mohamed Elbadawi, Edmond Fleischer, Anette Klinger, Gerhard Bringmann, Mohamed T. Khayyal, Thomas Efferth
Summary: This study evaluated the potential therapeutic values of naphthoquinone derivatives as Pgp modulators and found that NQ-2, NQ-3, and NQ-4 possess anti-inflammatory effects and can alleviate the inflammatory cascades associated with IBD. Furthermore, NQ-2 showed significant efficacy in treating colitis in rats.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cell Biology
Zhilin Zhang, Huan Zhang, Tian Chen, Lin Shi, Daorong Wang, Dong Tang
Summary: This article discusses the association between inflammatory bowel disease (IBD) and dysbiosis of the gut microbiota, which leads to persistent immune response and inflammation. Short-chain fatty acids (SCFAs) derived from fiber-rich diet produced by probiotic gut bacteria have shown anti-inflammatory effects and can delay the progression of IBD. The modulation of innate immune recognition and cytokine production by SCFAs may intervene in the progression of IBD. More studies are needed to investigate the clinical impact of SCFA.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Nutrition & Dietetics
Ping Kang, Yang Wang, Xiangen Li, Zhicheng Wan, Xiuying Wang, Huiling Zhu, Chunwei Wang, Shengjun Zhao, Huifu Chen, Yulan Liu
BRITISH JOURNAL OF NUTRITION
(2020)
Article
Nutrition & Dietetics
Xiao Xu, Hongwei Hua, Longmei Wang, Pengwei He, Lin Zhang, Qin Qin, Cheng Yu, Xiuying Wang, Guolong Zhang, Yulan Liu
BRITISH JOURNAL OF NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
Kan Xiao, Congcong Liu, Qin Qin, Yang Zhang, Xiuying Wang, Jing Zhang, Jack Odle, Xi Lin, Chien-An Andy Hu, Yulan Liu
Article
Cell Biology
Kan Xiao, Congcong Liu, Zhixiao Tu, Qiao Xu, Shaokui Chen, Yang Zhang, Xiuying Wang, Jing Zhang, Chien-An Andy Hu, Yulan Liu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cell Biology
Yulan Liu, Qiao Xu, Yang Wang, Tianzeng Liang, Xiangen Li, Dan Wang, Xiuying Wang, Huiling Zhu, Kan Xiao
Summary: Necroptosis, a newly discovered form of programmed cell death, plays a role in intestinal injury during sepsis. An inhibitor of necroptosis, Nec-1, has a preventive effect on intestinal injury.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Qiao Xu, Junjie Guo, Xiangen Li, Yang Wang, Dan Wang, Kan Xiao, Huiling Zhu, Xiuying Wang, Chien-An Andy Hu, Guolong Zhang, Yulan Liu
Summary: Necroptosis, a newly recognized form of programmed cell death with features of both necrosis and apoptosis, was found to occur in the liver during sepsis, contributing to septic hepatic injury. Inhibition of necroptosis led to reduced hepatic inflammation and damage in a piglet model of LPS-induced sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Junjie Guo, Tianzeng Liang, Huifu Chen, Xiangen Li, Xiaorui Ren, Xiuying Wang, Kan Xiao, Jiangchao Zhao, Huiling Zhu, Yulan Liu
Summary: The study demonstrates that glutamate protects against lipopolysaccharide-induced intestinal barrier dysfunction, potentially through modulation of the corticotropin-releasing factor signaling pathway.
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Mechanical
Xiuying Wang, Yu Chen, Kai Ding, Chengtao Yu
Summary: This study aims to obtain a design scheme of the surface texture on mechanical seal with lower friction and leakage. The optimal free-form dimple shows the best performance in terms of lower friction coefficient and leakage rate. The groove angled at 60 degrees to the direction of movement has lower friction but higher leakage.
INDUSTRIAL LUBRICATION AND TRIBOLOGY
(2023)
Article
Mechanics
Yu Chen, Xuze Wu, Xiuying Wang, Qingjie Kong, Chengtao Yu, Kai Wu
Summary: A novel dynamic model of angular contact ball bearing with clearance is proposed in this work, considering the elastic deformation and energy dissipation. The experiment test demonstrates the effectiveness of the proposed model and shows the impact of clearance on the dynamic characteristics of the ball bearing. Simulation results also highlight the significant role of contact force in the dynamic analysis.
Article
Chemistry, Physical
Wenjia Mi, Jiale An, Feng Zhang, Jun Zhao, Xiuying Wang
Summary: In this study, three dimensional graphene nanostructure (3DGN) was used as a substrate to synthesize FeF3.0.33H2O/3DGN composites by an in-situ microwave assisted method. The amount of 3DGN was found to play a crucial role in the morphology and electrochemical performance of the composites. The synthesized composites exhibited high reversible capacities and good cycling stability when used as cathode materials in lithium ion batteries. The improved electrochemical performance can be attributed to the synergistic effect of FeF3.0.33H2O nanoparticles and 3DGN.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Jiahao Liu, Mohan Zhou, Qilong Xu, Qingqing Lv, Junjie Guo, Xu Qin, Xiaoye Xu, Shaokui Chen, Jiangchao Zhao, Kan Xiao, Yulan Liu
Summary: Quercetin can attenuate intestinal injury and barrier dysfunction of piglets after deoxynivalenol exposure by modulating the necroptosis signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Pengfei Li, Xiuying Wang, Yin Zhang, Haoyu Wang, Jianjie Lu, Qiang Zhao, Licai Hao, Chunyu Peng, Wenjuan Lu, Zhiting Lin, Xiulong Wu
Summary: This paper presents a novel Radiation Hardened By Design Cell (RHBD-14T) using source isolation technology to reduce the number of sensitive nodes in order to improve the ability of static random access memory (SRAM) to resist single event upset. Compared with other radiation-hardened memory cells, RHBD-14T achieves better performance in terms of read and write delay times, power consumption, and noise margins.
MICROELECTRONICS JOURNAL
(2023)
Article
Engineering, Multidisciplinary
Wentao Shan, Yu Chen, Jun Huang, Xiuying Wang, Zhenhua Han, Kai Wu
Summary: This study proposes a general method for establishing the lubrication analysis model of ball bearing and uses CFD to reveal the oil-air multiphase flow characteristics inside the ball bearing. By introducing micro-clearance and increasing mesh density, the simulation model achieves convergence and accuracy. Experimental results demonstrate that this model accurately captures the lubrication characteristics of the ball bearing and displays the evolution of lubrication behavior under different lubrication states. The effects of structure characteristics and working condition on the lubrication performance are quantified.
RESULTS IN ENGINEERING
(2023)
Article
Agriculture, Dairy & Animal Science
Xiuying Wang, Kan Xiao, Cheng Yu, Longmei Wang, Tianzeng Liang, Huiling Zhu, Xiao Xu, Yulan Liu
Summary: XOS enhances intestinal mucosal integrity, regulates gene expression, and influences the microbial community structure, inhibiting inflammatory response and beneficially altering microbes and metabolites in the hindgut to protect the intestine from inflammation-related injury.