Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease

Skin and Mucosal Manifestations in NEMO Syndrome: A Case Series and Literature Review

(2022) Lucinda L. Kohn et al.   PEDIATRIC DERMATOLOGY

Interleukin-23 in the Pathogenesis of Inflammatory Bowel Disease and Implications for Therapeutic Intervention

(2022) Gavin W Sewell et al.   Journal of Crohns & Colitis

NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis

(2021) Carlo De Salvo et al.   JOURNAL OF CLINICAL INVESTIGATION

Bimekizumab efficacy and safety in moderate to severe plaque psoriasis (BE READY): a multicentre, double-blind, placebo-controlled, randomised withdrawal phase 3 trial

(2021) Kenneth B Gordon et al.   LANCET

Intermittent antibiotic treatment accelerated the development of colitis in IL-10 knockout mice

(2021) Shiyu Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Fecal Microbiome Changes and Specific Anti-Bacterial Response in Patients with IBD during Anti-TNF Therapy

(2021) Dagmar Schierova et al.   Cells

Serum Interleukin (IL)-23 and IL-17 Profile in Inflammatory Bowel Disease (IBD) Patients Could Differentiate between Severe and Non-Severe Disease

(2021) Laura A. Lucaciu et al.   Journal of Personalized Medicine

The development of colitis in Il10−/− mice is dependent on IL-22

(2020) Dilini C. Gunasekera et al.   Mucosal Immunology

Attenuation of intestinal inflammation in IL-10 deficient mice by a plasmid carrying Lactococcus lactis strain

(2020) Meritxell Zurita-Turk et al.   BMC BIOTECHNOLOGY

Whole exome sequencing analyses reveal gene–microbiota interactions in the context of IBD

(2020) Shixian Hu et al.   GUT

Genetic Factors and the Intestinal Microbiome Guide Development of Microbe-based Therapies for Inflammatory Bowel Diseases

(2019) Louis J. Cohen et al.   GASTROENTEROLOGY

Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease

(2019) Erik P. Karmele et al.   Mucosal Immunology

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2019) Bruce E. Sands et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fusobacterium nucleatum facilitates ulcerative colitis through activating IL‐17F signaling to NF‐κB via the upregulation of CARD3 expression

(2019) Yongyu Chen et al.   JOURNAL OF PATHOLOGY

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Sudabeh Alatab et al.   Lancet Gastroenterology & Hepatology

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota

(2018) Ce Tang et al.   NATURE IMMUNOLOGY

Divergent Roles of Interferon-γ and Innate Lymphoid Cells in Innate and Adaptive Immune Cell-Mediated Intestinal Inflammation

(2018) Jennifer Brasseit et al.   Frontiers in Immunology

OUP accepted manuscript

(2018)   Journal of Crohns & Colitis

Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells

(2018) A. Butera et al.   Scientific Reports

Interleukin 13-mediated colitis in the absence of IL-4Rα signalling

(2017) Jennifer C Hoving et al.   GUT

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity

(2017) Juan L. Mendoza et al.   IMMUNITY

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

Human genetic variation and the gut microbiome in disease

(2017) Andrew Brantley Hall et al.   NATURE REVIEWS GENETICS

Innate Lymphoid Cells in Intestinal Inflammation

(2017) Alessandra Geremia et al.   Frontiers in Immunology

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease

(2016) Stephan R Targan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A mouse model for ulcerative colitis based on NOD-scidIL2R γnullmice reconstituted with peripheral blood mononuclear cells from affected individuals

(2016) Pia Palamides et al.   Disease Models & Mechanisms

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

(2016) Konrad Aden et al.   Cell Reports

Predicting durable response or resistance to antitumor necrosis factor therapy in inflammatory bowel disease

(2016) Uri Kopylov et al.   Therapeutic Advances in Gastroenterology

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice

(2015) Katerina Vlantis et al.   GUT

Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study

(2015) Walter Reinisch et al.   GUT

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

(2015) Jacob S. Lee et al.   IMMUNITY

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

(2015) Stacey N. Harbour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells

(2014) Jenny M. Karo et al.   CELL

Involvement of IL-23 in enteropathic arthritis patients with inflammatory bowel disease: preliminary results

(2014) Tamer A. Gheita et al.   CLINICAL RHEUMATOLOGY

IL-12-and IL-23 in health and disease

(2014) Andrew L. Croxford et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study

(2014) Silvio Danese et al.   GUT

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Therapeutic activity of an interleukin-4/interleukin-13 dual antagonist on oxazolone-induced colitis in mice

(2014) Marion T. Kasaian et al.   IMMUNOLOGY

Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease

(2014) Wenyu Jiang et al.   INFLAMMATION RESEARCH

Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States

(2014) Antonia Kwan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rγnullmice engrafted with human peripheral blood mononuclear cells

(2013) T. Nolte et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Type I IFNs Regulate Effector and Regulatory T Cell Accumulation and Anti-Inflammatory Cytokine Production during T Cell-Mediated Colitis

(2013) A. Kole et al.   JOURNAL OF IMMUNOLOGY

Nod2 deficiency is associated with an increased mucosal immunoregulatory response to commensal microorganisms

(2013) A Amendola et al.   Mucosal Immunology

NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation

(2012) Kai Wang et al.   CELLULAR SIGNALLING

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

(2012) Martina Perše et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

(2012) Ana Camelo et al.   JOURNAL OF GASTROENTEROLOGY

Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon

(2012) Hamed Laroui et al.   PLoS One

Th17 Responses Are Not Induced in Dextran Sodium Sulfate Model of Acute Colitis

(2012) Yoon Suk Kim et al.   Immune Network

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

B Cells That Produce Immunoglobulin E Mediate Colitis in BALB/c Mice

(2011) Jennifer C. Hoving et al.   GASTROENTEROLOGY

Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: evidence for decreased platelet production

(2010) Jeffrey A. Sosman et al.   BRITISH JOURNAL OF HAEMATOLOGY

Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD)

(2010) T. KUCHARZIK et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis

(2010) Ting Feng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biomechanical changes in oxazolone-induced colitis in BALB/C mice

(2009) Jian Yang et al.   JOURNAL OF BIOMECHANICS

Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice

(2008) Reiko Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells

(2008) Yongpeng Gu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Direct Health Care Costs of Crohn's Disease and Ulcerative Colitis in US Children and Adults

(2008) Michael D. Kappelman et al.   GASTROENTEROLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

(2008) Ken Sugimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of IL-13 and NK T cells in experimental and human ulcerative colitis

(2008) I J Fuss et al.   Mucosal Immunology