Potassium Channels: A Potential Therapeutic Target for Parkinson’s Disease

The two-century journey of Parkinson disease research

(2017) Serge Przedborski   NATURE REVIEWS NEUROSCIENCE

Changes in SK channel expression in the basal ganglia after partial nigrostriatal dopamine lesions in rats: Functional consequences

(2017) Christiane Mourre et al.   NEUROPHARMACOLOGY

Blockade of fast A-type and TEA-sensitive potassium channels provide an antiparkinsonian effect in a 6-OHDA animal model

(2017) Hashem Haghdoost-Yazdi et al.   Neurosciences

Old and new challenges in Parkinson's disease therapeutics

(2017) Ana O. Pires et al.   PROGRESS IN NEUROBIOLOGY

The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal NeuronsIn Vivo

(2016) Henrik H. Hansen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Converging roles of ion channels, calcium, metabolic stress, and activity pattern ofSubstantia nigradopaminergic neurons in health and Parkinson's disease

(2016) Johanna Duda et al.   JOURNAL OF NEUROCHEMISTRY

Bee Venom for the Treatment of Parkinson Disease – A Randomized Controlled Clinical Trial

(2016) Andreas Hartmann et al.   PLoS One

Activation of ATP-sensitive potassium channels enhances DMT1-mediated iron uptake in SK-N-SH cells in vitro

(2016) Xixun Du et al.   Scientific Reports

Kv4 channel blockade reduces motor and neuropsychiatric symptoms in rodent models of Parkinson’s disease

(2015) Sabrine Aidi-knani et al.   BEHAVIOURAL PHARMACOLOGY

Dopamine midbrain neurons in health and Parkinson’s disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels

(2015) E. Dragicevic et al.   NEUROSCIENCE

Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease

(2015) Nicolas Maurice et al.   PLoS One

SK channel blockade reverses cognitive and motor deficits induced by nigrostriatal dopamine lesions in rats

(2014) Lin Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mutant α-Synuclein Enhances Firing Frequencies in Dopamine Substantia Nigra Neurons by Oxidative Impairment of A-Type Potassium Channels

(2014) Mahalakshmi Subramaniam et al.   JOURNAL OF NEUROSCIENCE

Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development

(2014) Martial A. Dufour et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Firing Pattern Modulation Through SK Channel Current Increase Underlies Neuronal Survival in an Organotypic Slice Model of Parkinson’s Disease

(2014) Yuan Wang et al.   MOLECULAR NEUROBIOLOGY

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

(2014) A M Dolga et al.   Cell Death & Disease

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

(2013) Jenny Lam et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+channels

(2013) Jon K. Maffie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model

(2013) Daniel Alvarez-Fischer et al.   PLoS One

Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels

(2013) Limin Shi et al.   Nature Communications

SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons

(2012) J. Deignan et al.   NEUROSCIENCE

Protective Roles for Potassium SK/KCa2 Channels in Microglia and Neurons

(2012) Amalia M. Dolga et al.   Frontiers in Pharmacology

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

(2011) John P. Adelman et al.   Annual Review of Physiology

Significant effects of 4-aminopyridine and tetraethylammonium in the treatment of 6-hydroxydopamine-induced Parkinson's disease

(2011) Hashem Haghdoost-Yazdi et al.   BEHAVIOURAL BRAIN RESEARCH

Bee Venom Reduces Neuroinflammation in the MPTP-Induced Model of Parkinson's Disease

(2011) Jong-In Kim et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Retigabine, a KV7 (KCNQ) potassium channel opener, attenuates l-DOPA-induced dyskinesias in 6-OHDA-lesioned rats

(2011) S.E. Sander et al.   NEUROPHARMACOLOGY

Role of Kv1 Potassium Channels in Regulating Dopamine Release and Presynaptic D2 Receptor Function

(2011) Philippe Martel et al.   PLoS One

M-type channels selectively control bursting in rat dopaminergic neurons

(2010) Guillaume Drion et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson’s disease?

(2010) Xiao-Kun Liu et al.   Neuroscience Bulletin

Novel Potassium Channel Blocker, 4-AP-3-MeOH, Inhibits Fast Potassium Channels and Restores Axonal Conduction in Injured Guinea Pig Spinal Cord White Matter

(2009) Wenjing Sun et al.   JOURNAL OF NEUROPHYSIOLOGY

Neuroprotective effects of bee venom pharmaceutical acupuncture in acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease

(2009) Ah-Reum Doo et al.   NEUROLOGICAL RESEARCH

SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta

(2008) T.D. Aumann et al.   EXPERIMENTAL NEUROLOGY

Synthesis and Structure−Activity Relationship Studies of 2-(N-Substituted)-aminobenzimidazoles as Potent Negative Gating Modulators of Small Conductance Ca2+-Activated K+Channels

(2008) Ulrik S. Sørensen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites

(2008) M. Day et al.   JOURNAL OF NEUROSCIENCE

Potassium channels: Possible new therapeutic targets in Parkinson’s disease

(2008) Yan Wang et al.   MEDICAL HYPOTHESES