Article
Biochemistry & Molecular Biology
Shunsuke Ando, Hiroya Mizutani, Makoto Muramatsu, Yumiko Hagihara, Hiroki Mishima, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura
Summary: This study investigates the role of SKCa and IKCa channels in regulating spontaneous Ca2+ oscillations in rat pinealocytes. The results show that SKCa channels, but not IKCa channels, contribute to the amplitude and frequency of spontaneous Ca2+ oscillations. The activity of SKCa2 channels plays a crucial role in controlling cytosolic Ca2+ signaling and melatonin production in the pineal gland.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Alexey I. Kuzmenkov, Steve Peigneur, Joshua A. Nasburg, Konstantin S. Mineev, Maxim V. Nikolaev, Ernesto Lopes Pinheiro-Junior, Alexander S. Arseniev, Heike Wulff, Jan Tytgat, Alexander A. Vassilevski
Summary: Apamin is a selective inhibitor of K(Ca)2 channels with no significant effects on other molecular targets. The spatial structure of apamin and its potential use as a pharmacological tool and drug design template for K(Ca)2 channels are supported by this study.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tuoxian Tang, Boshuo Jian, Zhenjiang Liu
Summary: Lysosomal ion channel TMEM175 is a unique potassium channel in lysosomes that plays a critical role in maintaining membrane potential, pH stability, and lysosome-autophagosome fusion. Recent studies have also revealed its proton-selective channel function. It is implicated in the pathogenesis of Parkinson's disease.
Article
Biochemistry & Molecular Biology
Lili Qu, Bingqian Lin, Wenping Zeng, Chunhong Fan, Haotian Wu, Yushu Ge, Qianqian Li, Canjun Li, Yanan Wei, Jing Xin, Xingbing Wang, Dan Liu, Chunlei Cang
Summary: Lysosomal potassium channel TMEM175 is regulated by apoptotic regulator Bcl-2, and its modulation plays an important role in cellular processes and Parkinson's disease.
Review
Oncology
Gulimirerouzi Fnu, Georg F. Weber
Summary: Cancer metastasis is associated with alterations in calcium, zinc, copper, potassium, sodium, and chloride homeostasis. Various drug candidates aimed at reversing these changes are in different stages of testing, with challenges including differences among tumor types and potential side effects from affecting healthy cells as well as transformed cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Maria Jose Sisalli, Salvatore Della Notte, Agnese Secondo, Carmelo Ventra, Lucio Annunziato, Antonella Scorziello
Summary: The study investigated whether pharmacological strategies improving mitochondrial functions could prevent neuronal dysfunction in Parkinson's disease. Using the amino acid ornithine, the compound LOLA was found to improve mitochondrial functions and reduce cytosolic calcium levels by modulating nitric oxide production. These results reveal the close relationship between cytosolic ionic homeostasis and cellular metabolism.
Review
Neurosciences
Sha Zhao, MengZhen Wang, ZeGang Ma
Summary: This review highlights the crucial roles of K-ATP channels in the pathogenesis of PD, and provides possible research directions from different perspectives such as vulnerability of dopamine neurons, neurotransmitter releasing, iron metabolism, α-synuclein secretion, and mitochondrial dysfunction, which are critical for investigation of K-ATP channels-targeted precise therapeutic interventions for PD.
BRAIN RESEARCH BULLETIN
(2021)
Article
Oncology
Chan-Chuan Liu, Cheng-Lin Wu, I-Chun Yeh, Sheng-Nan Wu, Chun- Sze, Po-Wu Gean
Summary: Continuous irradiation-induced resistance (CIIR) in GBM leads to TGF-beta secretion, activation of pro-survival Akt, downregulation of p21 independent of p53, upregulation of multi-drug resistant proteins, enhanced cell mobility and proliferation. CIIR also diminishes BK channel activity in an expression-independent manner. Cilostazol, a phosphodiesterase-3 inhibitor, can reverse CIIR-induced BK channel inactivation, potentially serving as a repurposed treatment for GBM.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Lei Xiong, Jin-Xiu Pan, Hao-han Guo, Lin Mei, Wen-Cheng Xiong
Summary: Patients with Parkinson's disease exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. Understanding the relationship between peripheral tissue deficits and brain pathology in PD development is still at an early stage, highlighting the complex interaction of genetic and environmental risk factors. Genetic mutations in various genes have been identified in PD patients, some of which are involved in regulation of bone metabolism, indicating potential links between PD risk genes and bone health.
CELL AND BIOSCIENCE
(2021)
Article
Multidisciplinary Sciences
Jinhong Wie, Zhenjiang Liu, Haikun Song, Thomas F. Tropea, Lu Yang, Huanhuan Wang, Yuling Liang, Chunlei Cang, Kimberly Aranda, Joey Lohmann, Jing Yang, Boxun Lu, Alice S. Chen-Plotkin, Kelvin C. Luk, Dejian Ren
Summary: This study uncovers a pathway by which extracellular growth factors regulate intracellular organelle function, and establishes a targetable mechanism by which common variants of TMEM175 confer risk for Parkinson's disease. The TMEM175 gene's common variants can increase or decrease the risk of developing Parkinson's disease, affecting neuronal damage and defense capabilities.
Article
Clinical Neurology
Jin Ho Jung, Han Kyu Na, Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Kyoungwon Baik, Sang Jin Kim, Young H. Sohn, Phil Hyu Lee
Summary: This study suggests that DHPs may be associated with better long-term cognitive outcomes in hypertensive patients with PD.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Jin Ho Jung, Han Kyu Na, Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Kyoungwon Baik, Sang Jin Kim, Young H. Sohn, Phil Hyu Lee
Summary: This study suggests that Dihydropyridines (DHPs) may have neuroprotective effects in patients with Parkinson's disease (PD) and hypertension. The use of DHPs was associated with a lower risk of developing dementia in hypertensive patients with PD.
MOVEMENT DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Paolo Zuccolini, Loretta Ferrera, Alessia Remigante, Cristiana Picco, Raffaella Barbieri, Sara Bertelli, Oscar Moran, Paola Gavazzo, Michael Pusch
Summary: This research investigated the effect of DCPIB on pancreatic duct adenocarcinoma (PDAC) and melanoma and found that DCPIB directly targeted BK channels and increased intracellular Ca2+ levels. These findings are important for the development of DCPIB-based modulators of ion channels and membrane proteins in the future.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jihyun Park, Kyung Mi Jang, Kwan-Kyu Park
Summary: Parkinson's disease (PD) is a neurodegenerative disorder associated with factors like oxidative stress, inflammation, and mitochondrial dysfunction. Ca2+ signaling plays a key role in PD and other neuronal diseases. This study found that apamin (APM), a selective antagonist of the SK channel, can suppress neuroinflammatory response. The researchers discovered that APM reduces Ca2+ overload from MPP+-induced neurotoxicity by regulating CaMKII, ERK, and NF kappa B / STAT3 signaling pathways. This suggests that APM may prevent loss of dopaminergic neurons through inhibition of Ca2+-overload-mediated signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shuai Guo, Zhenhui Chen, Peng-Sheng Chen, Michael Rubart
Summary: Ondansetron inhibits hSK2 currents even under altered ionic conditions, potentially showing antiarrhythmic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Samira Ztaou, Nicolas Maurice, Jeremy Camon, Gaelle Guiraudie-Capraz, Lydia Kerkerian-Le Goff, Corinne Beurrier, Martine Liberge, Marianne Amalric
JOURNAL OF NEUROSCIENCE
(2016)
Article
Behavioral Sciences
J. Mione, C. Manrique, Y. Duhoo, F. S. Roman, G. Guiraudie-Capraz
NEUROBIOLOGY OF LEARNING AND MEMORY
(2016)
Article
Neurosciences
Fanny Gaudel, Delphine Stephan, Verena Landel, Gilles Sicard, Francois Feron, Gaelle Guiraudie-Capraz
MOLECULAR NEUROBIOLOGY
(2019)
Article
Environmental Sciences
X. Moreau, G. Saez, A. Thiery, O. Clot-Faybesse, G. Guiraudie-Capraz, C. Bienboire-Frosini, C. Martin, L. De Jong
ENVIRONMENTAL POLLUTION
(2008)
Article
Neurosciences
G. Guiraudie-Capraz, F. A. Chaillan, B. Truchet, J. L. Franc, C. Mourre, F. S. Roman
Article
Neurosciences
Christine Manrique, Martine Migliorati, Valerie Gilbert, Jean-Michel Brezun, Franck A. Chaillan, Bruno Truchet, Michel Khrestchatisky, Gaelle Guiraudie-Capraz, Francois S. Roman
Article
Biochemistry & Molecular Biology
Chrystelle Le Danvic, Gaelle Guiraudie-Capraz, Djamel Abderrahmani, Jean-Pierre Zanetta, Patricia Nagnan-Le Meillour
JOURNAL OF CHEMICAL ECOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Maxime Bonnet, Gaelle Guiraudie-Capraz, Tanguy Marqueste, Stephane Garcia, Charlotte Jaloux, Patrick Decherchi, Francois Feron
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Romain Duroux, Anne Mandeau, Gaelle Guiraudie-Capraz, Yannick Quesnel, Estelle Loing
Article
Biochemistry & Molecular Biology
Fanny Gaudel, Gaelle Guiraudie-Capraz, Francois Feron
Summary: Animals heavily rely on chemical senses to explore the external environment, with various chemoreceptors identified in the human brain, particularly in the limbic system. The brain can detect bitterness, trace amines, and pheromonal cues, and the expression of chemoreceptor RNA varies with age but not with dementia or brain trauma. Further research is needed to fully understand how the brain processes endogenous chemicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
C. Jaloux, M. Witters, J. Veran, L. Giraudo, F. Sabatier, R. Lacroix, F. Dignat-George, M. Bonnet, T. Marqueste, P. Decherchi, M. Montava, G. Guiraudie Capraz, F. Feron
Summary: The research team focuses on the potential of olfactory stem cells for treating peripheral nerve injuries and has validated the effectiveness of this treatment method. Through clinical trials and animal model studies, olfactory stem cell grafting is beneficial for nerve regeneration and has a lower potential carcinogenic risk.
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
(2021)
Article
Zoology
Gaelle Guiraudie-Capraz, Dang Ba Pho, Jean-Marc Jallon
INTEGRATIVE ZOOLOGY
(2007)
Article
Behavioral Sciences
V Matarazzo, O Clot-Faybesse, B Marcet, G Guiraudie-Capraz, B Atanasova, G Devauchelle, M Cerutti, P Etiévant, C Ronin
Article
Behavioral Sciences
G Guiraudie-Capraz, MC Slomianny, P Pageat, C Malosse, AH Cain, P Orgeur, P Nagnan-Le Meillour
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.