Catching DNA with hoops—biophysical approaches to clarify the mechanism of SMC proteins

Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization

(2017) Marie-Laure Diebold-Durand et al.   MOLECULAR CELL

DNA's secret weapon against knots and tangles

(2017) Elie Dolgin   NATURE

SMC complexes differentially compact mitotic chromosomes according to genomic context

(2017) Stephanie Andrea Schalbetter et al.   NATURE CELL BIOLOGY

Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus

(2017) Xindan Wang et al.   SCIENCE

Overall Shapes of the SMC-ScpAB Complex Are Determined by Balance between Constraint and Relaxation of Its Structural Parts

(2017) Katsuhiko Kamada et al.   STRUCTURE

CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation

(2016) Matthias Merkenschlager et al.   Annual Review of Genomics and Human Genetics

Chromosome Compaction by Active Loop Extrusion

(2016) Anton Goloborodko et al.   BIOPHYSICAL JOURNAL

SnapShot: SMC Protein Complexes Part I

(2016) Christian H. Haering et al.   CELL

The 3D Genome as Moderator of Chromosomal Communication

(2016) Job Dekker et al.   CELL

Rapid movement and transcriptional re‐localization of human cohesin on DNA

(2016) Iain F Davidson et al.   EMBO JOURNAL

Cohesin acetylation and Wapl‐Pds5 oppositely regulate translocation of cohesin along DNA

(2016) Mai Kanke et al.   EMBO JOURNAL

MukB-mediated Catenation of DNA Is ATP and MukEF Independent

(2016) Soon Bahng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Reversible Association between Smc Coiled Coils Is Regulated by Lysine Acetylation and Is Required for Cohesin Association with the DNA

(2016) Irina Kulemzina et al.   MOLECULAR CELL

Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening

(2016) Ahmed M.O. Elbatsh et al.   MOLECULAR CELL

Intercalation-Based Single-Molecule Fluorescence Assay To Study DNA Supercoil Dynamics

(2016) Mahipal Ganji et al.   NANO LETTERS

SMC complexes: from DNA to chromosomes

(2016) Frank Uhlmann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Insights into Ring Formation of Cohesin and Related Smc Complexes

(2016) Thomas Gligoris et al.   TRENDS IN CELL BIOLOGY

Multistep assembly of DNA condensation clusters by SMC

(2016) HyeongJun Kim et al.   Nature Communications

Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic

(2016) Jorine M. Eeftens et al.   Cell Reports

Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin

(2016) Johannes Stigler et al.   Cell Reports

Formation of Chromosomal Domains by Loop Extrusion

(2016) Geoffrey Fudenberg et al.   Cell Reports

Compaction and segregation of sister chromatids via active loop extrusion

(2016) Anton Goloborodko et al.   eLife

Control of chromosome interactions by condensin complexes

(2015) Yuri Frosi et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA Binding

(2015) Young-Min Soh et al.   MOLECULAR CELL

Reconstitution of mitotic chromatids with a minimum set of purified factors

(2015) Keishi Shintomi et al.   NATURE CELL BIOLOGY

Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

(2015) Adrian L. Sanborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How cryo-EM is revolutionizing structural biology

(2015) Xiao-chen Bai et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Smc5/6 Complex Is an ATP-Dependent Intermolecular DNA Linker

(2015) Takaharu Kanno et al.   Cell Reports

SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis

(2015) Larissa Wilhelm et al.   eLife

Cohesin’s ATPase Activity Couples Cohesin Loading onto DNA with Smc3 Acetylation

(2014) Rene Ladurner et al.   CURRENT BIOLOGY

Interlinked Sister Chromosomes Arise in the Absence of Condensin during Fast Replication in B. subtilis

(2014) Stephan Gruber et al.   CURRENT BIOLOGY

The bright future of single-molecule fluorescence imaging

(2014) Manuel F Juette et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Single-molecule methods leap ahead

(2014) Taekjip Ha   NATURE METHODS

Characterization of a DNA exit gate in the human cohesin ring

(2014) P. J. Huis in 't Veld et al.   SCIENCE

The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement

(2014) Kristian Jeppsson et al.   PLoS Genetics

Entrapment of Chromosomes by Condensin Rings Prevents Their Breakage during Cytokinesis

(2013) Sara Cuylen et al.   DEVELOPMENTAL CELL

Chromosome segregation: how to open cohesin without cutting the ring?

(2013) Yasuto Murayama et al.   EMBO JOURNAL

Biochemical reconstitution of topological DNA binding by the cohesin ring

(2013) Yasuto Murayama et al.   NATURE

The SMC1-SMC3 cohesin heterodimer structures DNA through supercoiling-dependent loop formation

(2013) Mingxuan Sun et al.   NUCLEIC ACIDS RESEARCH

Molecular Basis of SMC ATPase Activation: Role of Internal Structural Changes of the Regulatory Subcomplex ScpAB

(2013) Katsuhiko Kamada et al.   STRUCTURE

Recent Advances in Magnetic Tweezers

(2012) Iwijn De Vlaminck et al.   Annual Review of Biophysics

Using DNA as a Fiducial Marker To Study SMC Complex Interactions with the Atomic Force Microscope

(2012) M.E. Fuentes-Perez et al.   BIOPHYSICAL JOURNAL

Condensin, Chromatin Crossbarring and Chromosome Condensation

(2012) Rahul Thadani et al.   CURRENT BIOLOGY

Condensins: universal organizers of chromosomes with diverse functions

(2012) T. Hirano   GENES & DEVELOPMENT

Self-organization of domain structures by DNA-loop-extruding enzymes

(2012) E. Alipour et al.   NUCLEIC ACIDS RESEARCH

High-Speed AFM Reveals the Dynamics of Single Biomolecules at the Nanometer Scale

(2011) Allard J. Katan et al.   CELL

Cohesin: a catenase with separate entry and exit gates?

(2011) Kim Nasmyth   NATURE CELL BIOLOGY

Condensin structures chromosomal DNA through topological links

(2011) Sara Cuylen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lessons Learned from UvrD Helicase: Mechanism for Directional Movement

(2010) Wei Yang   Annual Review of Biophysics

Targeting X chromosomes for repression

(2010) Barbara J Meyer   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mechanics of DNA bridging by bacterial condensin MukBEF in vitro and in singulo

(2010) Zoya M Petrushenko et al.   EMBO JOURNAL

Cohesin: Its Roles and Mechanisms

(2009) Kim Nasmyth et al.   Annual Review of Genetics

Recruitment of Condensin to Replication Origin Regions by ParB/SpoOJ Promotes Chromosome Segregation in B. subtilis

(2009) Stephan Gruber et al.   CELL

Recruitment of SMC by ParB-parS Organizes the Origin Region and Promotes Efficient Chromosome Segregation

(2009) Nora L. Sullivan et al.   CELL

Translocation and Unwinding Mechanisms of RNA and DNA Helicases

(2008) Anna Marie Pyle   Annual Review of Biophysics

Motor step size and ATP coupling efficiency of the dsDNA translocase EcoR124I

(2008) Ralf Seidel et al.   EMBO JOURNAL

The cohesin ring concatenates sister DNA molecules

(2008) Christian H. Haering et al.   NATURE

MukB acts as a macromolecular clamp in DNA condensation

(2008) Yuanbo Cui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY