A simplified characterization of S-adenosyl-l-methionine-consuming enzymes with 1-Step EZ-MTase: a universal and straightforward coupled-assay for in vitro and in vivo setting

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

(2016) H Chen et al.   ONCOGENE

A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase

(2016) Erik W. Debler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity

(2016) Yi-Ru Lee et al.   Scientific Reports

The emerging role of lysine methyltransferase SETD8 in human diseases

(2016) Ciro Milite et al.   Clinical Epigenetics

Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

(2016) Zbynek Heger et al.   PLoS One

A fluorescence resonance energy transfer-based method for histone methyltransferases

(2015) Kanchan Devkota et al.   ANALYTICAL BIOCHEMISTRY

Histone H2A and H4 N-terminal Tails Are Positioned by the MEP50 WD Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase

(2015) Emmanuel S. Burgos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

A continuous kinetic assay for protein and DNA methyltransferase enzymatic activities

(2015) Shai Duchin et al.   Epigenetics & Chromatin

A Sensitive Luminescent Assay for the Histone Methyltransferase NSD1 and Other SAM-Dependent Enzymes

(2014) Katherine M. Drake et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis

(2014) Lu Wang et al.   CANCER CELL

Small Molecule Control of Chromatin Remodeling

(2014) Aidan Finley et al.   CHEMISTRY & BIOLOGY

8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research

(2014) Jacek Wierzchowski et al.   Molecular BioSystems

Potent Inhibition of the C–P Lyase Nucleosidase PhnI by Immucillin-A Triphosphate

(2013) Siddhesh S. Kamat et al.   BIOCHEMISTRY

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

(2013) S. R. Daigle et al.   BLOOD

The role of genetics in the establishment and maintenance of the epigenome

(2013) Covadonga Huidobro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deciphering post-translational modification codes

(2013) Adam P. Lothrop et al.   FEBS LETTERS

Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer

(2013) Xiangxiang Bao et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Structure-Guided Discovery of New Deaminase Enzymes

(2013) Daniel S. Hitchcock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Post-translational modifications and the Warburg effect

(2013) T Hitosugi et al.   ONCOGENE

Impact of Site-Directed Mutant Luciferase on Quantitative Green and Orange/Red Emission Intensities in Firefly Bioluminescence

(2013) Yu Wang et al.   Scientific Reports

Luciferase-Based Assay for Adenosine: Application to S-Adenosyl-l-homocysteine Hydrolase

(2012) Emmanuel S. Burgos et al.   ANALYTICAL CHEMISTRY

Femtomolar Inhibitors Bind to 5′-Methylthioadenosine Nucleosidases with Favorable Enthalpy and Entropy

(2012) Keisha Thomas et al.   BIOCHEMISTRY

Methylthioadenosine Deaminase in an Alternative Quorum Sensing Pathway in Pseudomonas aeruginosa

(2012) Rong Guan et al.   BIOCHEMISTRY

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation

(2012) J. Song et al.   SCIENCE

Characterizing DNA Methyltransferases With An Ultrasensitive Luciferase-Linked Continuous Assay

(2011) Ivan Hemeon et al.   ANALYTICAL CHEMISTRY

The diverse functions of Dot1 and H3K79 methylation

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

Protein Arginine Methyltransferase Prmt5-Mep50 Methylates Histones H2A and H4 and the Histone Chaperone Nucleoplasmin inXenopus laevisEggs

(2011) Carola Wilczek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical evaluation of PRMT1 gene expression in breast cancer

(2011) Konstantina Mathioudaki et al.   TUMOR BIOLOGY

An enzyme-coupled ultrasensitive luminescence assay for protein methyltransferases

(2010) Glorymar Ibáñez et al.   ANALYTICAL BIOCHEMISTRY

Preliminary X-ray analysis of twinned crystals of sarcosine dimethylglycine methyltransferase fromHalorhodospira halochoris

(2009) Juha Pekka Kallio et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

A fast and efficient method for quantitative measurement of S-adenosyl-l-methionine-dependent methyltransferase activity with protein substrates

(2009) Brenda B. Suh-Lailam et al.   ANALYTICAL BIOCHEMISTRY

Enzymatic stereospecific preparation of fluorescent S-adenosyl-l-methionine analogs

(2009) Otmar M. Ottink et al.   ANALYTICAL BIOCHEMISTRY

The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans

(2009) S. S. Wolf   CELLULAR AND MOLECULAR LIFE SCIENCES

GlycineN-Methyltransferase and Regulation ofS-Adenosylmethionine Levels

(2009) Zigmund Luka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure−Activity Study of New Inhibitors of Human Betaine-HomocysteineS-Methyltransferase

(2009) Václav Vaněk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of sarcosine dimethylglycine methyltransferase fromGaldieria sulphuraria

(2008) Jason G. McCoy et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases

(2007) Tiffany L. Graves et al.   ANALYTICAL BIOCHEMISTRY