The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants

Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides

(2017) Jeffrey S. Derrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reexamining Alzheimer's Disease: Evidence for a Protective Role for Amyloid-β Protein Precursor and Amyloid-β

(2017) Rudy J. Castellani et al.   JOURNAL OF ALZHEIMERS DISEASE

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Simplest Monodentate Imidazole Stabilization of the oxy-Tyrosinase Cu2 O2 Core: Phenolate Hydroxylation through a CuIII Intermediate

(2016) Linus Chiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Wilson's disease and other neurological copper disorders

(2015) Oliver Bandmann et al.   LANCET NEUROLOGY

Dioxygen activation in the Cu–amyloid β complex

(2015) Andrea Mirats et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative proteomics using SILAC: Principles, applications, and developments

(2015) Xiulan Chen et al.   PROTEOMICS

Metalloproteins Containing Cytochrome, Iron–Sulfur, or Copper Redox Centers

(2014) Jing Liu et al.   CHEMICAL REVIEWS

Recent advances in stable isotope labeling based techniques for proteome relative quantification

(2014) Yuan Zhou et al.   JOURNAL OF CHROMATOGRAPHY A

3D Structures and Redox Potentials of Cu2+–Aβ(1–16) Complexes at Different pH: A Computational Study

(2014) Jorge Alí-Torres et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults

(2014) Miranka Wirth et al.   NEUROBIOLOGY OF AGING

Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β

(2014) Alaina S. DeToma et al.   Chemical Science

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production

(2013) Laure-Estelle Cassagnes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Hsp90 Is Cleaved by Reactive Oxygen Species at a Highly Conserved N-Terminal Amino Acid Motif

(2012) Raphaël Beck et al.   PLoS One

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Non-Conjugated Small Molecule FRET for Differentiating Monomers from Higher Molecular Weight Amyloid Beta Species

(2011) Chongzhao Ran et al.   PLoS One

Copper dioxygen (bio)inorganic chemistry

(2010) Edward I. Solomon et al.   FARADAY DISCUSSIONS

Alzheimer's Aβ Peptides with Disease-Associated N-Terminal Modifications: Influence of Isomerisation, Truncation and Mutation on Cu2+ Coordination

(2010) Simon C. Drew et al.   PLoS One

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening Assay for Metal-Catalyzed Oxidation Inhibitors Using Liquid Chromatography−Mass Spectrometry with an N-Terminal β-Amyloid Peptide

(2009) Koichi Inoue et al.   ANALYTICAL CHEMISTRY

Small Molecule Modulators of Copper-Induced Aβ Aggregation

(2009) Sarmad S. Hindo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Studies of Copper(I) Complexes of Amyloid-β Peptide Fragments: Formation of Two-Coordinate Bis(histidine) Complexes

(2008) Richard A. Himes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid β−Cu2+Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2Catalytically but Quench Hydroxyl Radicals†

(2008) Rebecca C. Nadal et al.   BIOCHEMISTRY

The Structure of the Amyloid-β Peptide High-Affinity Copper II Binding Site in Alzheimer Disease

(2008) Victor A. Streltsov et al.   BIOPHYSICAL JOURNAL

Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents

(2008) Wei-hui Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Neuroscience: The plaque plan

(2008) Alison Abbott   NATURE

Activation of large-conductance Ca2+-activated K+ channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 mice

(2008) Hui Ye et al.   NEUROBIOLOGY OF AGING

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

A mass spectrometry-based strategy for detecting and characterizing endogenous proteinase activities in complex biological samples

(2008) Sarah Robinson et al.   PROTEOMICS