Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity

Glycan-Based Cell Targeting To Modulate Immune Responses

(2017) Timo Johannssen et al.   TRENDS IN BIOTECHNOLOGY

Influence of Core β-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting

(2016) Katarzyna Brzezicka et al.   ACS Chemical Biology

C-type lectins: their network and roles in pathogen recognition and immunity

(2016) Sabine Mayer et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Intrahepatic regulation of antiviral T cell responses at initial stages of viral infection

(2016) Yuejin Liang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis

(2016) Ya-Lang Huang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions

(2016) Kshitij Khatri et al.   MOLECULAR & CELLULAR PROTEOMICS

Sweet fullerenes vanquish viruses

(2016) Sébastien Vidal   Nature Chemistry

Differential Use of the C-Type Lectins L-SIGN and DC-SIGN for Phlebovirus Endocytosis

(2016) Psylvia Léger et al.   TRAFFIC

Dengue Fever: Causes, Complications, and Vaccine Strategies

(2016) Niyati Khetarpal et al.   Journal of Immunology Research

Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN

(2016) Leah Gillespie et al.   Scientific Reports

Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes

(2016) Yi-Lin Cheng et al.   Scientific Reports

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

(2015) Stefania Ordanini et al.   CHEMICAL COMMUNICATIONS

Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

(2015) Stéphane P. Vincent et al.   CHEMISTRY-A EUROPEAN JOURNAL

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Recent insights into structures and functions of C-type lectins in the immune system

(2015) Kurt Drickamer et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The HIV glycan shield as a target for broadly neutralizing antibodies

(2015) Katie J. Doores   FEBS Journal

Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors

(2015) Salvador Iborra et al.   IMMUNOBIOLOGY

Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses

(2015) Ryoko Kiyotake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus

(2015) Wy Ching Ng et al.   JOURNAL OF VIROLOGY

The Roles of Direct Recognition by Animal Lectins in Antiviral Immunity and Viral Pathogenesis

(2015) Yang Liu et al.   MOLECULES

Human Lectins and Their Roles in Viral Infections

(2015) Christopher Mason et al.   MOLECULES

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

(2015) Antonio Muñoz et al.   Nature Chemistry

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

(2015) Zihou Deng et al.   NATURE IMMUNOLOGY

MGL Receptor and Immunity: When the Ligand Can Make the Difference

(2015) Ilaria Grazia Zizzari et al.   Journal of Immunology Research

Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology

(2015) Jonathan J. Lyons et al.   Frontiers in Pediatrics

Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In Vivo

(2015) Anne-Laure Flamar et al.   PLoS One

A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

(2014) Norbert Varga et al.   BIOMATERIALS

Biological Evaluation of Multivalent Lewis X-MGL-1 Interactions

(2014) Magdalena Eriksson et al.   CHEMBIOCHEM

Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death

(2014) Konstantin Neumann et al.   IMMUNITY

The sweet spot: defining virus–sialic acid interactions

(2014) Jennifer E. Stencel-Baerenwald et al.   NATURE REVIEWS MICROBIOLOGY

Investigating virus–glycan interactions using glycan microarrays

(2014) David F Smith et al.   Current Opinion in Virology

Correction: The Mannose Receptor Mediates Dengue Virus Infection of Macrophages

(2014) Joanna L Miller et al.   PLoS Pathogens

Targeting C-type lectin receptors with multivalent carbohydrate ligands

(2013) Bernd Lepenies et al.   ADVANCED DRUG DELIVERY REVIEWS

Glycofullerenes Inhibit Viral Infection

(2013) Joanna Luczkowiak et al.   BIOMACROMOLECULES

DCIR interacts with ligands from both endogenous and pathogenic origin

(2013) Karien Bloem et al.   IMMUNOLOGY LETTERS

Glycodendrimers prevent HIV transmission via DC-SIGN on dendritic cells

(2013) J. J. Garcia-Vallejo et al.   INTERNATIONAL IMMUNOLOGY

DC-SIGN, DC-SIGNR and LSECtin: C-Type Lectins for Infection

(2013) Feng Zhang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation

(2013) Maha Maglinao et al.   JOURNAL OF CONTROLLED RELEASE

The C-Type Lectin Receptor DCIR Is Crucial for the Development of Experimental Cerebral Malaria

(2013) M. Maglinao et al.   JOURNAL OF IMMUNOLOGY

Liver Sinusoidal Endothelial Cell Lectin Inhibits CTL-Dependent Virus Clearance in Mouse Models of Viral Hepatitis

(2013) B. Liu et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Immunoreceptor Regulates Chikungunya Virus Pathogenesis in Mice

(2013) K. M. Long et al.   JOURNAL OF VIROLOGY

The Macrophage Galactose-Type Lectin Can Function as an Attachment and Entry Receptor for Influenza Virus

(2013) W. C. Ng et al.   JOURNAL OF VIROLOGY

Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain

(2013) Karien Bloem et al.   PLoS One

Binding of HIV-1 gp120 to DC-SIGN Promotes ASK-1-Dependent Activation-Induced Apoptosis of Human Dendritic Cells

(2013) Yongxiong Chen et al.   PLoS Pathogens

Glycan-based DC-SIGN targeting to enhance antigen cross-presentation in anticancer vaccines

(2013) Juan J. García-Vallejo et al.   OncoImmunology

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Cellular Uptake of Gold Nanoparticles Bearing HIV gp120 Oligomannosides

(2012) Blanca Arnáiz et al.   BIOCONJUGATE CHEMISTRY

CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages

(2012) M.-F. Wu et al.   BLOOD

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Targeting tumor antigens to dendritic cells using particulate carriers

(2012) Medha D. Joshi et al.   JOURNAL OF CONTROLLED RELEASE

The mannose receptor

(2012) Luisa Martinez-Pomares   JOURNAL OF LEUKOCYTE BIOLOGY

The Glycopolymer Code: Synthesis of Glycopolymers and Multivalent Carbohydrate-Lectin Interactions

(2012) C. Remzi Becer   MACROMOLECULAR RAPID COMMUNICATIONS

Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation

(2012) Yvette van Kooyk et al.   MOLECULAR IMMUNOLOGY

Forty-Five Years of Marburg Virus Research

(2012) Kristina Brauburger et al.   Viruses-Basel

Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection

(2012) Renato Ribeiro-Viana et al.   Nature Communications

CLEC5A Regulates Japanese Encephalitis Virus-Induced Neuroinflammation and Lethality

(2012) Szu-Ting Chen et al.   PLoS Pathogens

A glycomimetic compound inhibits DC-SIGN-mediated HIV infection in cellular and cervical explant models

(2011) Angela Berzi et al.   AIDS

Involvement of viral envelope GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin

(2011) Katsuaki Usami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pseudosaccharide Functionalized Dendrimers as Potent Inhibitors of DC-SIGN Dependent Ebola Pseudotyped Viral Infection

(2011) Joanna Luczkowiak et al.   BIOCONJUGATE CHEMISTRY

DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway

(2011) A. A. Lambert et al.   BLOOD

Mechanisms and principles of N-linked protein glycosylation

(2011) Flavio Schwarz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Langerin, the “Catcher in the Rye”: An important receptor for pathogens on Langerhans cells

(2011) Patrizia Stoitzner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation

(2011) Michiel van der Vlist et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission

(2011) Ronaldo Celerino da Silva et al.   HUMAN IMMUNOLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

(2011) Fabiola Osorio et al.   IMMUNITY

Structural Flexibility of the Macrophage Dengue Virus Receptor CLEC5A

(2011) Aleksandra A. Watson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 N-Glycan Composition Governs a Balance between Dendritic Cell-Mediated Viral Transmission and Antigen Presentation

(2011) T. van Montfort et al.   JOURNAL OF IMMUNOLOGY

Exploiting Dendrimer Multivalency To Combat Emerging and Re-Emerging Infectious Diseases

(2011) Meredith A. Mintzer et al.   MOLECULAR PHARMACEUTICS

Glycodendrimers as functional antigens and antitumor vaccines

(2011) Tze Chieh Shiao et al.   NEW JOURNAL OF CHEMISTRY

Syk-coupled C-type lectins in immunity

(2011) Ann M. Kerrigan et al.   TRENDS IN IMMUNOLOGY

Inhibition of DC-SIGN-Mediated HIV Infection by a Linear Trimannoside Mimic in a Tetravalent Presentation

(2010) Sara Sattin et al.   ACS Chemical Biology

Chemical Approaches to Glycobiology

(2010) Laura L. Kiessling et al.   Annual Review of Biochemistry

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

(2010) E. Klechevsky et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Fullerene sugar balls

(2010) Jean-François Nierengarten et al.   CHEMICAL COMMUNICATIONS

Glycans as receptors for influenza pathogenesis

(2010) Karthik Viswanathan et al.   GLYCOCONJUGATE JOURNAL

Viruses and Langerhans cells

(2010) Anthony L Cunningham et al.   IMMUNOLOGY AND CELL BIOLOGY

Langerin functions as an antiviral receptor on Langerhans cells

(2010) Michiel van der Vlist et al.   IMMUNOLOGY AND CELL BIOLOGY

Adaptive immunity

(2010) Francisco A. Bonilla et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Different Potential of C-Type Lectin-Mediated Entry between Marburg Virus Strains

(2010) K. Matsuno et al.   JOURNAL OF VIROLOGY

Macrophage Receptors for Influenza A Virus: Role of the Macrophage Galactose-Type Lectin and Mannose Receptor in Viral Entry

(2010) J. P. Upham et al.   JOURNAL OF VIROLOGY

C-type lectin Langerin is a β-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi

(2010) Marein A.W.P. de Jong et al.   MOLECULAR IMMUNOLOGY

Targeting early infection to prevent HIV-1 mucosal transmission

(2010) Ashley T. Haase   NATURE

HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells

(2010) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Dendritic Cells and HIV-1 Trans-Infection

(2010) David McDonald   Viruses-Basel

HIV-1 Induces DCIR Expression in CD4+ T Cells

(2010) Alexandra A. Lambert et al.   PLoS Pathogens

Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor

(2009) Aleksandra A. Watson et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

Multivalent Manno-Glyconanoparticles Inhibit DC-SIGN-Mediated HIV-1 Trans-Infection of Human T Cells

(2009) Olga Martínez-Ávila et al.   CHEMBIOCHEM

Multivalent ligand presentation as a central concept to study intricate carbohydrate–protein interactions

(2009) Narayanaswamy Jayaraman   CHEMICAL SOCIETY REVIEWS

GoldManno-Glyconanoparticles: Multivalent Systems to Block HIV-1 gp120 Binding to the Lectin DC-SIGN

(2009) Olga Martínez-Ávila et al.   CHEMISTRY-A EUROPEAN JOURNAL

Liver Sinusoidal Endothelial Cell Lectin, LSECtin, Negatively Regulates Hepatic T-Cell Immune Response

(2009) Li Tang et al.   GASTROENTEROLOGY

Lectins as pattern recognition molecules: The effects of epitope density in innate immunity

(2009) T. K Dam et al.   GLYCOBIOLOGY

Influence of the mannose receptor in host immune responses

(2009) Umut Gazi et al.   IMMUNOBIOLOGY

Oligomerization of the Macrophage Mannose Receptor Enhances gp120-mediated Binding of HIV-1

(2009) Joey Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12

(2009) M. Inui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells

(2009) Marjoleine L. Op den Brouw et al.   VIROLOGY

The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways

(2008) A. A. Lambert et al.   BLOOD

Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-  production

(2008) F. Meyer-Wentrup et al.   BLOOD

Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses

(2008) Sandra J van Vliet et al.   IMMUNOLOGY AND CELL BIOLOGY

TNF-α and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo

(2008) Marein A.W.P. de Jong et al.   JOURNAL OF CLINICAL INVESTIGATION

DC-SIGN and L-SIGN: the SIGNs for infection

(2008) Ui-Soon Khoo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Branched oligosaccharide structures on HBV prevent interaction with both DC-SIGN and L-SIGN

(2008) M. L. Op den Brouw et al.   JOURNAL OF VIRAL HEPATITIS

CLEC5A is critical for dengue-virus-induced lethal disease

(2008) Szu-Ting Chen et al.   NATURE

Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells

(2008) Noriyuki Fujikado et al.   NATURE MEDICINE

Sialic acids in human health and disease

(2008) Ajit Varki   TRENDS IN MOLECULAR MEDICINE

Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding

(2008) Thomas Gramberg et al.   VIROLOGY