Recent advances in imine reductase-catalyzed reactions

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

(2018) Scott P. France et al.   ChemCatChem

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

(2017) P. Matzel et al.   GREEN CHEMISTRY

Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

(2017) Tanja Knaus et al.   GREEN CHEMISTRY

Reductive amination of ketones catalyzed by whole cell biocatalysts containing imine reductases (IREDs)

(2017) Zaira Maugeri et al.   JOURNAL OF BIOTECHNOLOGY

A reductive aminase from Aspergillus oryzae

(2017) Godwin A. Aleku et al.   Nature Chemistry

Enantioselective Synthesis of 1-Aryl-Substituted Tetrahydroisoquinolines Employing Imine Reductase

(2017) Jinmei Zhu et al.   ACS Catalysis

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

(2017) Lorna J. Hepworth et al.   ACS Catalysis

Application of Imine Reductases (IREDs) in Micro-Aqueous Reaction Systems

(2016) Zaira Maugeri et al.   ADVANCED SYNTHESIS & CATALYSIS

The biochemical characterization of three imine-reducing enzymes from Streptosporangium roseum DSM43021, Streptomyces turgidiscabies and Paenibacillus elgii

(2016) Philipp N. Scheller et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Asymmetric Ketone Reduction by Imine Reductases

(2016) Maike Lenz et al.   CHEMBIOCHEM

A NADH-accepting imine reductase variant: Immobilization and cofactor regeneration by oxidative deamination

(2016) Martin Gand et al.   JOURNAL OF BIOTECHNOLOGY

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

(2016) Scott P. France et al.   ACS Catalysis

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

(2016) Scott P. France et al.   ACS Catalysis

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

(2016) Godwin A. Aleku et al.   ACS Catalysis

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases

(2016) Jackson K. B. Cahn et al.   ACS Synthetic Biology

Efficient Synthesis of Chiral Indolines using an Imine Reductase from Paenibacillus lactis

(2015) Hao Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalytic Imine Reduction and Reductive Amination of Ketones

(2015) Joerg H. Schrittwieser et al.   ADVANCED SYNTHESIS & CATALYSIS

Structure, Activity and Stereoselectivity of NADPH-Dependent Oxidoreductases Catalysing theS-Selective Reduction of the Imine Substrate 2-Methylpyrroline

(2015) Henry Man et al.   CHEMBIOCHEM

Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein-Sequence Space

(2015) Dennis Wetzl et al.   CHEMBIOCHEM

Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles

(2015) Rachel S. Heath et al.   ChemCatChem

An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

(2015) Shahed Hussain et al.   ChemCatChem

Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones

(2015) Philipp N. Scheller et al.   ChemCatChem

Cascade catalysis – strategies and challenges en route to preparative synthetic biology

(2015) Jan Muschiol et al.   CHEMICAL COMMUNICATIONS

InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines

(2015) Gideon Grogan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases

(2014) Philipp N. Scheller et al.   CHEMBIOCHEM

Direct Reductive Amination of Ketones: Structure and Activity ofS-Selective Imine Reductases fromStreptomyces

(2014) Tobias Huber et al.   ChemCatChem

A novel chimeric amine dehydrogenase shows altered substrate specificity compared to its parent enzymes

(2014) Bettina R. Bommarius et al.   CHEMICAL COMMUNICATIONS

Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis

(2014) Hannes Kohls et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Characterization of three novel enzymes with imine reductase activity

(2014) M. Gand et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Structure and Activity of NADPH-Dependent Reductase Q1EQE0 fromStreptomyces kanamyceticus, which Catalyses theR-Selective Reduction of an Imine Substrate

(2013) María Rodríguez-Mata et al.   CHEMBIOCHEM

Asymmetric Reduction of Cyclic Imines Catalyzed by a Whole-Cell Biocatalyst Containing an (S)-Imine Reductase

(2013) Friedemann Leipold et al.   ChemCatChem

Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

(2013) Diego Ghislieri et al.   TOPICS IN CATALYSIS

Development of an Amine Dehydrogenase for Synthesis of Chiral Amines

(2012) Michael J. Abrahamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A NADPH-dependent (S)-imine reductase (SIR) from Streptomyces sp. GF3546 for asymmetric synthesis of optically active amines: purification, characterization, gene cloning, and expression

(2012) Koichi Mitsukura et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Systematic evaluation of the dihydrogen-oxidising and NAD+-reducing soluble [NiFe]-hydrogenase from Ralstonia eutropha H16 as a cofactor regeneration catalyst

(2011) Juliane Ratzka et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Purification and Characterization of a Novel (R)-Imine Reductase fromStreptomycessp. GF3587

(2011) Koichi MITSUKURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Hydrolases in the Stereoselective Synthesis ofN-Heterocyclic Amines and Amino Acid Derivatives

(2011) Eduardo Busto et al.   CHEMICAL REVIEWS

Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

(2010) Thomas C. Nugent et al.   ADVANCED SYNTHESIS & CATALYSIS

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Fully Enzymatic Resolution of Chiral Amines: Acylation and Deacylation in the Presence ofCandida antarcticaLipase B

(2008) Hilda Ismail et al.   ADVANCED SYNTHESIS & CATALYSIS