Article
Medical Laboratory Technology
Peina Shi, Haojun Song, Xiaoyun Ding
Summary: The novel circRNA hsa_circ_001888 was significantly downregulated in gastric cancer cell lines, tissues, and plasma samples, indicating its potential as a biomarker for diagnosing gastric cancer and its involvement in gastric cancer development.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Cell Biology
Ruiting Guo, Xixi Cui, Xue Li, Wen Zang, Mingjie Chang, Zenghui Sun, Zhifang Liu, Yundong Sun, Jihui Jia, Wenjuan Li
Summary: This study found that Helicobacter pylori can induce the upregulation of circMAN1A2 in gastric cancer cells, and the downregulation of circMAN1A2 can inhibit the growth and invasion of gastric cancer cells. Furthermore, circMAN1A2 promotes the progression of H. pylori-induced gastric cancer by regulating the expression of MTA2. This study suggests that circMAN1A2 may be a potential diagnostic marker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Bangbo Zhao, Zeru Li, Cheng Qin, Tianhao Li, Yuanyang Wang, Hongtao Cao, Xiaoying Yang, Weibin Wang
Summary: Pancreatic cancer is a common digestive system cancer with poor prognosis. Circular RNAs have been found to play important roles in cancer progression and communication between cells, indicating potential as diagnostic biomarkers and predictors of treatment response and prognosis in pancreatic cancer. Further research efforts should focus on exploring the ceRNA networks involving circRNAs and their clinical applications.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xiaoqi Yang, Tao Ye, Haoran Liu, Peng Lv, Chen Duan, Xiaoliang Wu, Kehua Jiang, Hongyan Lu, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang, Zhangqun Ye
Summary: circRNAs play crucial regulatory roles in BCa by modulating various biological behaviors through miRNA sponging mechanisms. The expression levels of circRNAs are significantly associated with clinicopathologic characteristics and can be used to predict patient survival parameters. Due to their abundance, conservation, stability, specificity, and detectability, circRNAs are considered potential diagnostic and prognostic biomarkers for BCa.
Review
Biochemistry & Molecular Biology
Ligia I. Torsin, George E. D. Petrescu, Alexandru A. Sabo, Baoqing Chen, Felix M. Brehar, Mihnea P. Dragomir, George A. Calin
Summary: The text discusses the dysregulated levels and alterations of non-coding RNAs (ncRNAs) in cancer, as well as the emerging focus on modifications to ncRNAs as a potential part of the tumorigenic process. Understanding this extra regulatory layer is crucial in translating knowledge about ncRNAs and their modifications into clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Gongbo Du, Runsheng Ma, Hongqiang Li, Jiao He, Kaixiang Feng, Dongpeng Niu, Detao Yin
Summary: The over-expression of hsa_circ_0002111 promotes papillary thyroid cancer (PTC) and may serve as a potential diagnostic biomarker and therapeutic target for PTC according to the study findings.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yu Zhang, Dong-Dong Jia, Yi-Fei Zhang, Meng-Die Cheng, Wen-Xiu Zhu, Pei-Feng Li, Yin-Feng Zhang
Summary: Thyroid cancer is a common malignant tumor with high morbidity and mortality rates worldwide. Circular RNAs may serve as potential biomarkers and therapeutic targets for both thyroid cancer and autoimmune thyroid disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Shuo Ma, Xinliang Gu, Lei Shen, Yinhao Chen, Chen Qian, Xianjuan Shen, Shaoqing Ju
Summary: The specific circRNA circHAS2 was upregulated in gastric cancer tissues and cells, and was positively correlated with tumor metastasis. Knockdown of circHAS2 or addition of hsa-miR-944 mimics inhibited proliferation, migration, and invasion of GC cells. The circHAS2/hsa-miR-944/PPM1E axis may be involved in the progression of GC, suggesting circHAS2 as a potential biomarker and therapeutic target for GC.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Quanbin Zha, Xi Wu, Jingxin Zhang, Tingting Xu, YongKang Shi, Yayun Sun, Yuan Fang, Yunru Gu, Pei Ma, Yongqian Shu, Shengwang Tian
Summary: The highly expressed circular RNA hsa_circ_0007967 in gastric cancer was found to promote cell proliferation by acting as a sponge for miR-411-5p and increasing MAML3 expression. This suggests that hsa_circ_0007967 could serve as a potential biomarker for gastric cancer diagnosis and a target for treatment.
CELL DEATH DISCOVERY
(2022)
Review
Genetics & Heredity
Chun-Yi Xu, Xi-Xi Zeng, Li-Feng Xu, Ming Liu, Feng Zhang
Summary: Gastric cancer is the fourth leading cause of cancer death worldwide, especially prevalent in East Asia, where the lack of specific early-stage symptoms results in most patients being diagnosed at an advanced stage. Therefore, finding more sensitive and reliable biomarkers for gastric cancer screening and diagnosis is urgently needed.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Xianjuan Shen, Shan Kong, Shuo Ma, Lei Shen, Ming Zheng, Shiyi Qin, Jing Qi, Qiuhong Wang, Xiaopeng Cui, Shaoqing Ju
Summary: The circRNA hsa_circ_0000437 was found to play a significant role in gastric cancer progression, promoting cell proliferation, migration, invasion, and apoptosis resistance. It was also found to induce lymph node metastasis through the HSPA2-ERK signaling pathway. Clinical data showed that hsa_circ_0000437 was enriched in the serum of gastric cancer patients and was associated with lymph node metastasis. These findings suggest that hsa_circ_0000437 may serve as a potential biomarker for lymph node metastasis in gastric cancer patients.
Review
Pathology
Soudeh Ghafouri-Fard, Kasra Honarmand Tamizkar, Elena Jamali, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Gastric cancer is closely related to environmental factors such as chronic infection with Helicobacter pylori, and high-throughput genome and transcriptome analysis has provided insights into its molecular mechanisms. However, data on circRNA expression in gastric cancer remains inconsistent, requiring further investigation. CircRNA could potentially serve as biomarkers and therapeutic targets for gastric cancer, yet more experiments are needed for clinical application.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Medicine, Research & Experimental
Bo Cao, Guoxiao Liu, Wang Zhang, Yajiao Shi, Bo Wei
Summary: Gastric cancer is a malignancy with high incidence and mortality rates globally, and non-coding RNAs, including circRNAs and lncRNAs, have been shown to play important roles in gastric carcinogenesis, serving as potential biomarkers for clinical diagnosis and prognosis. While significant progress has been made, there are still numerous issues to be addressed and further development is needed in this field.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Ruogu Wang, Hongyao Zhang, Dan Zhang, Qilong Wang, Fang Wang, Qingsi He
Summary: In this study, the expression profile of circular RNA (cRNA) in gastric cancer tissues and plasma was explored as a potential molecular marker for gastric cancer detection. The expression profile of cRNA in normal gastric tissue was also investigated. The results showed that certain circRNAs have distinct expression patterns in the plasma and tissues of gastric cancer patients, and a quantitative RT ddPCR approach was developed to identify circRNAs associated with clinicopathological factors and prognosis. The study provides new insights into the diagnostic and prognostic potential of circRNAs in gastric cancer, and a dye-based RT ddPCR method is shown to be an effective and economical technique for plasma circRNA detection.
Article
Oncology
Liang Chen, Ge Shan
Summary: Circular RNAs play crucial roles in tumorigenesis and tumor development by promoting or suppressing cancers through different molecular mechanisms. With advancements in nucleic acid-based therapeutic tools, circRNAs could be explored as targetable molecules in future cancer treatments.
Review
Medicine, Research & Experimental
Li-Yun Fu, Shu-Wei Wang, Meng-Yuan Hu, Zhen-Luo Jiang, Li-Li Shen, Yu-Ping Zhou, Jun-Ming Guo, Yao-Ren Hu
Summary: Circular RNAs play a significant role in liver diseases, serving as potential diagnostic and prognostic markers with therapeutic translational value.
Article
Gastroenterology & Hepatology
Jianing Yan, Yongfu Shao, Haoxuan Lu, Qihua Ye, Guoliang Ye, Junming Guo
Summary: The study revealed that hsa_circ_0001020 is significantly upregulated in GC cell lines, tissue samples, and plasma, showing associations with distal metastasis and blood CA19-9. High hsa_circ_0001020 expression in GC patients correlated with decreased survival time, indicating its potential as an independent prognostic factor. The circRNA demonstrated superior screening potential as a biomarker for GC compared to traditional markers like CEA and CA19-9, and may provide insights into oncogenic pathways like the FoxO and p53 signaling pathways.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Cell & Tissue Engineering
Linwen Zhu, Zhe Li, Xiuchong Yu, Yao Ruan, Yijing Shen, Yongfu Shao, Xinjun Zhang, Guoliang Ye, Junming Guo
Summary: tRF-5026a is downregulated in gastric cancer patients and has a certain diagnostic value for predicting overall survival. It suppresses proliferation, migration, and cell cycle progression of gastric cancer cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Yibo Ma, Zhe Li, Dongnan Ma, Junming Guo, Weiliang Sun
Summary: The study found that hsa_circ_0003195 plays an important role in the diagnosis and prognosis of gastric cancer, and may be a new diagnostic and prognostic marker. The expression level of hsa_circ_0003195 is down-regulated in tissues and plasma from gastric cancer patients, and is correlated with differentiation, TNM stages, lymphatic metastasis, and distal metastasis.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Yongfu Shao, Changlei Qi, Jianing Yan, Rongdan Lu, Guoliang Ye, Junming Guo
Summary: Hsa_circ_0086720 is found to be downregulated in gastric cancer and stably exists in plasma. As a biomarker for early gastric cancer screening, plasma Hsa_circ_0086720 has good sensitivity and specificity, and it can predict the prognosis of patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Genetics & Heredity
Qiuyan Weng, Yao Wang, Yaoyao Xie, Xiuchong Yu, Shuangshuang Zhang, Jiaxin Ge, Zhe Li, Guoliang Ye, Junming Guo
Summary: This review summarizes the biogenesis and classification of tRFs, discusses the biological functions of EV-associated tRFs, and explores their roles as potential biomarkers in human diseases.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Medicine, General & Internal
Qiuyan Weng, Zhe Li, Yaoyao Xie, Junming Guo, Yong Zhang, Guoliang Ye
Summary: This study analyzed the clinicopathological characteristics of long-term survivors with non-metastatic gastric signet ring cell carcinoma and identified independent predictors of long-term survival. Age, race, sex, marital status, tumor size, tumor infiltration, and lymph node involvement were found to be significant factors in predicting long-term survival.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Oncology
Zhe Li, Yi Xie, Bingxiu Xiao, Junming Guo
Summary: This study reveals that hsa_circ_0006282 is downregulated in gastric cancer and suppresses the growth of gastric cancer by regulating the PTEN/AKT signaling pathway.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiuchong Yu, Xuemei Song, Yaoyao Xie, Shuangshuang Zhang, Junming Guo
Summary: In this study, a quantitative method was established to detect plasma tRF-27 in gastric cancer patients. It was found that plasma tRF-27 levels were significantly increased and closely related to tumor size and Ki67 expression in gastric cancer patients. tRF-27 may serve as an independent predictor of overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medical Laboratory Technology
Chunli Cao, Yao Wang, Xinxin Wu, Zhe Li, Junming Guo, Weiliang Sun
Summary: This review describes the expression, function, and mechanism of circRNA-associated mTOR in various cancers. CircRNA-associated mTOR can regulate the progression and therapy of cancers through multiple signaling pathways.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Yao Wang, Qiuyan Weng, Jiaxin Ge, Xinjun Zhang, Junming Guo, Guoliang Ye
Summary: tsRNAs, derived from tRNAs, play versatile roles in protein synthesis and fundamental biological processes. They regulate gene silencing, RNA stability, and translation, and are closely associated with cell proliferation, migration, cell cycle, and apoptosis. Abnormal expression of tsRNAs is linked to various human diseases, particularly cancer.
Article
Biochemistry & Molecular Biology
Ruan Yao, Guo Jun-Ming, Xiao Bing-Xiu
Summary: Circular RNAs are considered potential tumor biomarkers due to their unique structure and widespread presence in body fluids. Digital PCR technology, as the third generation PCR, enhances detection sensitivity without the need for a standard curve, thus improving detection accuracy, especially for low-expressed RNAs.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Oncology
Xueping Tao, Yongfu Shao, Jianing Yan, Liyang Yang, Qihua Ye, Qingling Wang, Rongdan Lu, Junming Guo
Summary: Circular RNAs (circRNAs) are endogenous RNA molecules produced by alternative splicing, which play important roles in the proliferation, differentiation, invasion, and metastasis of cancer cells through various mechanisms. They are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Oncology
Yijing Shen, Yaoyao Xie, Xiuchong Yu, Shuangshuang Zhang, Qiuyan Wen, Guoliang Ye, Junming Guo
Summary: The study identified a new tRF, tRF-19-3L7L73JD, with lower expression in gastric cancer patients, and its levels were found to be related to tumor size. Screening with tRF-19-3L7L73JD may serve as a diagnostic tool for gastric cancer. Furthermore, tRF-19-3L7L73JD demonstrated inhibitory effects on the growth of gastric cancer cells.
Article
Medicine, General & Internal
Yijing Shen, Xiuchong Yu, Yao Ruan, Zhe Li, Yaoyao Xie, Zhilong Yan, Junming Guo
Summary: This study identified a global tsRNA profile in plasma from gastric cancer patients, revealing 21 upregulated and 46 downregulated tsRNAs. Among them, tRF-33-P4R8YP9LON4VDP was found to inhibit proliferation of gastric cancer cells, suggesting its potential as a diagnostic biomarker and therapeutic target for gastric cancer.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
