CircRNA in cancer: Fundamental mechanism and clinical potential

Identification of mecciRNAs and their roles in the mitochondrial entry of proteins

(2020) Xu Liu et al.   Science China-Life Sciences

circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma

(2020) JunFeng Wang et al.   Cell Death & Disease

circRNA circFUT8 Upregulates Krüpple-like Factor 10 to Inhibit the Metastasis of Bladder Cancer via Sponging miR-570-3p

(2020) Qingqing He et al.   Molecular Therapy-Oncolytics

CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA Binding Proteins and Sponging MiR-942

(2020) Chi Hin Wong et al.   CANCER RESEARCH

Circular RNA circKIF4A Sponges miR-375/1231 to Promote Bladder Cancer Progression by Upregulating NOTCH2 Expression

(2020) Ying-rui Shi et al.   Frontiers in Pharmacology

The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells

(2020) Nele Van Der Steen et al.   Cancers

Circular RNA LPAR3 sponges microRNA‐198 to facilitate esophageal cancer migration, invasion, and metastasis

(2020) Yijun Shi et al.   CANCER SCIENCE

Hsa_circ_0009910: oncogenic circular RNA targets microRNA-145 in ovarian cancer cells

(2020) Ying Li et al.   CELL CYCLE

CircRNA circ_0072995 promotes the progression of epithelial ovarian cancer by modulating miR-147a/CDK6 axis

(2020) Jin Ding et al.   Aging-US

Identification and characterization of tumorigenic circular RNAs in cervical cancer

(2020) Huan Huang et al.   CELLULAR SIGNALLING

Circular RNA circEXOC6B Inhibits the Progression of Ovarian Cancer by Sponging miR-421 and Regulating RUS1 Expression

(2020) Zhonghai Wang et al.   OncoTargets and Therapy

Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression

(2020) Tingting Zhang et al.   Molecular Therapy-Nucleic Acids

Up-regulation of circ-SMAD7 inhibits tumor proliferation and migration in esophageal squamous cell carcinoma

(2019) Yanzhou Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Analyses of a Panel of Transcripts Identified From a Small Sample Size and Construction of RNA Networks in Hepatocellular Carcinoma

(2019) Zhiyong Sheng et al.   Frontiers in Genetics

Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKα signaling in STK11 mutant lung cancer

(2019) Xiuyuan Chen et al.   Autophagy

Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression

(2019) Liling Deng et al.   GENE

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

(2019) Zhuoan Cheng et al.   Nature Communications

Circular RNA Cdr1as upregulates SCAI to suppress cisplatin resistance in Ovarian Cancer via miR-1270 suppression

(2019) Zhao Zhao et al.   Molecular Therapy-Nucleic Acids

Immune checkpoint inhibitors of PD-L1 as cancer therapeutics

(2019) Akintunde Akinleye et al.   Journal of Hematology & Oncology

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

ΔNp63α exerts antitumor functions in cervical squamous cell carcinoma

(2019) Ying Zhou et al.   ONCOGENE

Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1

(2019) Qiu Tang et al.   Aging-US

Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer

(2019) Fengjiao Wang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation

(2019) Dong Yan et al.   EBioMedicine

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice

(2019) Chen Diling et al.   Aging-US

Comprehensive analysis of the regulatory network of differentially expressed mRNAs, lncRNAs and circRNAs in gastric cancer

(2019) Yingyi Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression

(2019) Hanqing Hong et al.   Cell Death & Disease

Twist1 regulates Vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma

(2018) Jing Meng et al.   CANCER RESEARCH

The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma

(2018) Mantang Qiu et al.   CANCER RESEARCH

RNA-binding protein trinucleotide repeat-containing 6A regulates the formation of circular RNA circ0006916, with important functions in lung cancer cells

(2018) Xin Dai et al.   CARCINOGENESIS

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1

(2018) Ling Fang et al.   CELL DEATH AND DIFFERENTIATION

Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer

(2018) Shuangyan Tan et al.   CELL RESEARCH

Recent advances in galactose-engineered nanocarriers for the site-specific delivery of siRNA and anticancer drugs

(2018) Ashay Jain et al.   DRUG DISCOVERY TODAY

A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs

(2018) Chuan Huang et al.   GENES & DEVELOPMENT

circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression

(2018) Bo Chen et al.   Theranostics

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Global microarray profiling identifiedhsa_circ_0064428as a potential immune-associated prognosis biomarker for hepatocellular carcinoma

(2018) Qiaoyou Weng et al.   JOURNAL OF MEDICAL GENETICS

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway

(2018) Haiyang Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression

(2017) Dan Han et al.   HEPATOLOGY

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

(2017) Tuğçe Aktaş et al.   NATURE

Circular RNAs in cancer: opportunities and challenges in the field

(2017) L S Kristensen et al.   ONCOGENE

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer

(2017) Fan Yang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

(2017) Lorenzo Errichelli et al.   Nature Communications

Global circular RNA expression profile of human gastric cancer and its clinical significance

(2017) Yongfu Shao et al.   Cancer Medicine

Defective control of pre–messenger RNA splicing in human disease

(2016) Benoit Chabot et al.   JOURNAL OF CELL BIOLOGY

Detecting circular RNAs: bioinformatic and experimental challenges

(2016) Linda Szabo et al.   NATURE REVIEWS GENETICS

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

The emerging landscape of circular RNA in life processes

(2016) Shibin Qu et al.   RNA Biology

Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation

(2016) Wenjia Xia et al.   Scientific Reports

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Circular RNAs in Eukaryotic Cells

(2015) Liang Chen et al.   CURRENT GENOMICS

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation

(2015) Liang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

Short intronic repeat sequences facilitate circular RNA production

(2014) Dongming Liang et al.   GENES & DEVELOPMENT

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

(2010) Christin E. Burd et al.   PLoS Genetics

RNA interference as a gene knockdown technique

(2009) Ge Shan   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The RNA-Binding Protein RBM3 Is Required for Cell Proliferation and Protects Against Serum Deprivation-Induced Cell Death

(2009) Sven Wellmann et al.   PEDIATRIC RESEARCH