Regulatory T-cell therapy in liver transplantation

Hepatic Infiltrates in Operational Tolerant Patients After Liver Transplantation Show Enrichment of Regulatory T Cells Before Proinflammatory Genes Are Downregulated

(2016) R. Taubert et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation

(2016) Satoru Todo et al.   HEPATOLOGY

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation

(2016) Niloufar Safinia et al.   Oncotarget

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

Intrahepatic Activation of Naive CD4+T Cells by Liver-Resident Phagocytic Cells

(2014) Szun S. Tay et al.   JOURNAL OF IMMUNOLOGY

Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34+ Stem Cells-Reconstituted NOD-scid IL2rγnull Mice

(2014) Fang Xiao et al.   PLoS One

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

(2013) Carlos Benítez et al.   HEPATOLOGY

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Enrichment of Regulatory T Cells in Acutely Rejected Human Liver Allografts

(2012) R. Taubert et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Natural History of Clinical Operational Tolerance After Kidney Transplantation Through Twenty-Seven Cases

(2012) S. Brouard et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Differing Effects of Rapamycin or Calcineurin Inhibitor on T-Regulatory Cells in Pediatric Liver and Kidney Transplant Recipients

(2012) T. Akimova et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory T-cell therapy for transplantation

(2012) Qizhi Tang et al.   Current Opinion in Organ Transplantation

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Complete Immunosuppression Withdrawal and Subsequent Allograft Function Among Pediatric Recipients of Parental Living Donor Liver Transplants

(2012) Sandy Feng et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Early tacrolimus exposure after liver transplantation: Relationship with moderate/severe acute rejection and long-term outcome

(2012) Manuel Rodríguez-Perálvarez et al.   JOURNAL OF HEPATOLOGY

Reduced-Dose Tacrolimus with Mycophenolate Mofetil vs. Standard-Dose Tacrolimus in Liver Transplantation: A Randomized Study

(2011) K. Boudjema et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

The dynamic changes of Th17/Treg cytokines in rat liver transplant rejection and tolerance

(2011) Jinzheng Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Regulatory T Cells Produced by Inhibiting Cyclic Nucleotide Phosphodiesterase Type 3 Prevent Allograft Rejection

(2011) G. Feng et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression

(2010) Scott M. Steward-Tharp et al.   Annals of the New York Academy of Sciences

NFAT pulls the strings during CD4+ T helper cell effector functions

(2010) N. Hermann-Kleiter et al.   BLOOD

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Foxp3+ CD4 Regulatory T Cells Limit Pulmonary Immunopathology by Modulating the CD8 T Cell Response during Respiratory Syncytial Virus Infection

(2010) R. B. Fulton et al.   JOURNAL OF IMMUNOLOGY

Induced tolerance to rat liver allografts involves the apoptosis of intragraft T cells and the generation of CD4+CD25+FoxP3+T regulatory cells

(2010) Masato Fujiki et al.   LIVER TRANSPLANTATION

Preferential increase in memory and regulatory subsets during T-lymphocyte immune reconstitution after Thymoglobulin induction therapy with maintenance sirolimus vs cyclosporine

(2010) Emmanuel Morelon et al.   TRANSPLANT IMMUNOLOGY

Long-Term Follow-Up of 23 Operational Tolerant Liver Transplant Recipients

(2010) Panagiotis Tryphonopoulos et al.   TRANSPLANTATION

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Immunosuppression withdrawal improves long-term metabolic parameters, cardiovascular risk factors and renal function in liver transplant patients

(2009) Jose A. Pons et al.   CLINICAL TRANSPLANTATION

Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death

(2008) Lauren E. Holz et al.   GASTROENTEROLOGY

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

(2008) Julia Yuen-Shan Tsang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Tor Vergata weaning off immunosuppression protocol in stable HCV liver transplant patients: The updated follow up at 78 months

(2008) Giuseppe Orlando et al.   TRANSPLANT IMMUNOLOGY

Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective

(2008) Anthony J. Demetris et al.   TRANSPLANT INTERNATIONAL

Hepatic Stellate Cells Preferentially Expand Allogeneic CD4+CD25+FoxP3+ Regulatory T Cells in an IL-2-Dependent Manner

(2008) Guoping Jiang et al.   TRANSPLANTATION

Interferon-γ Conditioning Ex Vivo Generates CD25+CD62L+Foxp3+ Regulatory T Cells That Prevent Allograft Rejection: Potential Avenues for Cellular Therapy

(2008) Gang Feng et al.   TRANSPLANTATION

Exhaustive Differentiation of Alloreactive CD8+ T Cells: Critical for Determination of Graft Acceptance or Rejection

(2008) Ulrich Steger et al.   TRANSPLANTATION

The Presence of Foxp3 Expressing T Cells Within Grafts of Tolerant Human Liver Transplant Recipients

(2008) Ying Li et al.   TRANSPLANTATION

FoxP3 in Peripheral Blood Is Associated With Operational Tolerance in Liver Transplant Patients During Immunosuppression Withdrawal

(2008) José A. Pons et al.   TRANSPLANTATION