Review
Endocrinology & Metabolism
Ziru Li, Clifford J. Rosen
Summary: Bone marrow adipose tissue (BMAT) is a significant component of the bone marrow space in healthy adults, but its expansion is associated with aging, obesity, anorexia nervosa, and irradiation. While traditionally viewed as a negative component, recent studies have revealed that BMAT can serve as an energy reservoir and also plays a role in regulating bone formation and hematopoiesis. This review summarizes the unique characteristics of BMAT and provides an updated understanding of its physiological roles based on a newly established mouse model.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Zhaowei Teng, Yun Zhu, Da Lin, Qinggang Hao, Qiaoning Yue, Xiaochao Yu, Shuo Sun, Lihong Jiang, Sheng Lu
Summary: We systematically investigate the genome and epigenetic landscape of BMMSCs and identify common and specific chromatin loops among BMMSCs, osteoblasts, and adipocytes. Multi-omics analysis reveals genes and SNPs associated with bone degeneration and osteoporosis. Additionally, potential drug targets such as DAAM2, TIMP2, and TMEM241 are identified.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Review
Endocrinology & Metabolism
Erica L. Scheller, Meghan E. McGee-Lawrence, Beata Lecka-Czernik
Summary: The BMA2020 meeting aimed to facilitate communication and collaboration among scientists worldwide interested in bone marrow adiposity research, attracting experts from various fields including bone biology, endocrinology, and stem cell biology.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Jun-Goo Kwak, Jungwoo Lee
Summary: Chemoresistance is a significant problem in the effective treatment of bone metastasis. Adipocytes in the bone marrow may play a crucial role in developing microenvironment-driven chemoresistance, but detailed investigation is challenging due to the anatomical inaccessibility and tissue complexity.
Article
Immunology
E. Yaneth Osorio, Zbigniew Gugala, Grace T. Patterson, Genesis Palacios, Erika Cordova, Ashanti Uscanga-Palomeque, Bruno L. Travi, Peter C. Melby
Summary: This study investigates how malnutrition and inflammation affect bone marrow composition and bone health, finding that inflammatory challenges exacerbate bone marrow changes and weaken bone formation in malnourished mice. Inflammatory challenge promotes the differentiation of mesenchymal stem cells towards adipocytes instead of osteoblasts, and increases bone resorption. However, dietary intake of omega-3 fatty acids may reduce inflammation and improve bone health in malnutrition.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Ziru Li, Ormond A. MacDougald
Summary: Laboratory mice are a valuable preclinical model for studying common human diseases related to osteopenia or hematopoietic disorders. However, factors such as species, age, sex, skeletal site, and treatment protocol should all be taken into consideration when choosing the appropriate model for future studies.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell & Tissue Engineering
Shiva Moein, Naser Ahmadbeigi, Rezvan Adibi, Sara Kamali, Kobra Moradzadeh, Pardis Nematollahi, Nance Beyer Nardi, Yousof Gheisari
Summary: Large multinucleated cells (LMCs) found in long-term culture of bone marrow mesenchymal cells play an important role in tissue regeneration and resistance to stressors. This study investigates the presence and characteristics of LMCs in native bone marrow and their role in bone marrow reconstitution following injury. The results indicate that LMCs can produce mononucleated cells that contribute to tissue repair and are associated with adipogenesis and bone marrow reconstruction.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Taoyuan Zhang, Linhe Lu, Man Li, Ding Zhang, Peng Yu, Xinhao Zhang, Zheng Zhang, Chong Lei
Summary: This study aimed to investigate the effects and underlying mechanism of bone marrow mesenchymal stem cell-derived exosomes (BMMSC-Exo) in acute lung injury (ALI) after cardiopulmonary bypass (CPB). The results showed that BMMSC-Exo treatment improved inflammation, oxidative stress, and pyroptosis-related protein expression, as well as decreased the secretion of inflammatory factors. Moreover, BMMSC-Exo suppressed ALI by activating the YAP/beta-catenin signaling pathway.
Article
Endocrinology & Metabolism
Ji Yeon Lee, Jae-Yeon Yang, Sang Wan Kim
Summary: Lineage-tracing studies have shown that parathyroid hormone and anti-sclerostin antibody can convert bone lining cells into active osteoblasts, while these cells may also differentiate into bone marrow adipocytes. Rosiglitazone can stimulate this differentiation process, but Scl-Ab administration may suppress it, contributing to anabolic effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Nina N. Sorensen, Christina M. Andreasen, Pia R. Jensen, Ellen M. Hauge, Jens Bollerslev, Jean-Marie Delaisse, Moustapha Kassem, Abbas Jafari, Marta Diaz-delCastillo, Thomas L. Andersen
Summary: This study found that increased cortisol production in patients with CS leads to increased bone marrow adiposity, primarily mediated by adipocyte hypertrophy. The differential pattern of adiposity in patients with CS and GC-O highlights that bone marrow adipocytes and their progenitors may respond differently in these two GC-mediated bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Kazuki Inoue, Yongli Qin, Yuhan Xia, Jie Han, Ruoxi Yuan, Jun Sun, Ren Xu, Jean X. Jiang, Matthew B. Greenblatt, Baohong Zhao
Summary: Adipoq-lineage progenitors in bone marrow are the main cellular source of M-CSF, producing much higher levels than osteoblast lineage cells. Deficiency of M-CSF in these progenitors significantly reduces the generation of bone marrow macrophages and osteoclasts, leading to severe osteopetrosis.
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: MSCs are a heterogeneous cell population found in various tissues in the body, with important regulatory functions, especially in the bone marrow where they play a critical role in regulating HSCs. They contribute to maintaining bone integrity and hormonal nutrition supply, as well as regulating the homeostasis and differentiation of the HSC niche through differentiation into different cell types. Research on MSCs helps understand their role in regulating cell interactions and homeostasis in the body.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: Mesenchymal stromal cells (MSCs) are a diverse cell population known for their nutrient-producing and immunomodulatory functions, crucial in regulating hematopoietic stem cells (HSC) in the bone marrow for blood production and immunity. MSCs contribute to bone integrity and hormone supply by differentiating into osteoblasts and adipocytes, playing a key role in the complex interactions of the HSC niche.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shinya Sato, Toru Hiruma, Mitsuyuki Koizumi, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Hiroko Tadokoro, Sadako Motomatsu, Takashi Yamanaka, Kota Washimi, Yoichiro Okubo, Emi Yoshioka, Rika Kasajima, Toshinari Yamashita, Takeshi Kishida, Tomoyuki Yokose, Yohei Miyagi
Summary: Bone metastasis is a common occurrence in cancer patients, and it is crucial to explore the mechanisms of cancer progression in order to develop effective therapies. In this study, the role of bone marrow adipocytes in cancer cells was investigated, revealing that they create a favorable tumor microenvironment for cancer invasion and therapeutic resistance through the induction of cancer-associated fibroblasts (CAFs) and immune evasion. These findings provide a potential target for the treatment of bone metastasis.
Review
Oncology
Michaela R. Reagan, Heather Fairfield, Clifford J. Rosen
Summary: This review discusses the important roles of bone marrow adipose tissue in cancer progression and the potential clinical implications. It highlights the expansion of bone marrow adipose tissue during aging and obesity, primarily comprised of adipocytes and other cells. Research is ongoing to understand the origins, functions, and interactions of these cells in cancer, with a focus on developing better therapies for bone cancers.
Article
Cell & Tissue Engineering
Kentaro Endo, Naoki Fujita, Takayuki Nakagawa, Ryohei Nishimura
TISSUE ENGINEERING PART A
(2019)
Article
Medicine, Research & Experimental
So Suzuki, Mitsuru Mizuno, Yuriko Sakamaki, Ayako Mimata, Kentaro Endo, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya
LABORATORY INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Ayako Tsuji, Naomi Kojima, Ken Watanabe, Norio Shimizu, Tomohiro Morio, Ichiro Sekiya
Article
Multidisciplinary Sciences
Kiyotaka Horiuchi, Nobutake Ozeki, Kentaro Endo, Mitsuru Mizuno, Hisako Katano, Masako Akiyama, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya
Summary: The study demonstrates that thawed MSCs show comparable inhibitory effects on OA progression in rats to cultured MSCs. Additionally, in the rat OA model, the thawed MSC group had significantly lower gross finding and histological scores compared to the cryopreservation fluid group.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Naoki Amano, Masaki Nomura, Yoshinori Hasegawa, Nobutake Ozeki, Hideyuki Koga, Naoko Takasu, Osamu Ohara, Tomohiro Morio, Ichiro Sekiya
Summary: The study aimed to investigate the safety of synovial MSCs with trisomy 7 by transplanting them into patients and following up for 5 years. Results showed that synovial MSCs with trisomy 7 were comparable to MSCs without trisomy 7 in terms of safety.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Misaki Yagi, Mitsuru Mizuno, Ryota Fujisawa, Hisako Katano, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya
Summary: This study investigated the optimal pore size of honeycomb PLA films for in vitro cartilage formation using synovial MSCs. The results showed that the 5 μm pore size was more suitable for cartilage formation compared to the 20 μm pore size.
STEM CELLS INTERNATIONAL
(2021)
Article
Anatomy & Morphology
Yuji Kohno, Mitsuru Mizuno, Kentaro Endo, Nobutake Ozeki, Hisako Katano, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Koga, Ichiro Sekiya
Summary: This study aimed to determine whether the yield of synovial fluid MSCs could predict the ultimate yield of primary MSCs from the synovium of patients with RA. The results showed a positive correlation between the number of synovial fluid cells and synovial cells, and the synovial fluid MSCs exhibited MSC-like characteristics and multi-differentiation potential. These findings reveal the feasibility of using synovial fluid MSC yield to predict the synovial MSC yield.
Article
Cell & Tissue Engineering
Yugo Miura, Kentaro Endo, Keiichiro Komori, Ichiro Sekiya
Summary: This study aimed to improve the biological function of osteoarthritis (OA) synovial mesenchymal stem cells (MSCs) by removing senescent cells using the senolytic drug ABT-263. The results showed that ABT-263 pretreatment significantly reduced the percentage of senescent cells and increased apoptosis in MSCs. The pretreated cells also showed enhanced colony formation ability and adipogenic and chondrogenic capabilities, as well as lower expression of senescence markers and inflammation factors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Shunichi Fujii, Kentaro Endo, Seiya Matsuta, Keiichiro Komori, Ichiro Sekiya
Summary: The study compared the yields and biological properties of infrapatellar fat pad-derived mesenchymal stem cells (MSCs) and dedifferentiated fat (DFAT) cells. The results showed that MSCs had higher cell yields, while DFAT cells exhibited higher adipogenic and chondrogenic potentials.
REGENERATIVE THERAPY
(2022)
Article
Cell & Tissue Engineering
Hideto Furuoka, Kentaro Endo, Ichiro Sekiya
Summary: This study clarified the relationship between the numbers of synovial fluid mesenchymal stem cells (SF-MSCs) and joint structural changes during osteoarthritis (OA) progression. It was found that SF-MSCs in an OA environment had phenotypes favorable for tissue repair.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Kentaro Endo, Kiyotaka Horiuchi, Hisako Katano, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya
Summary: A new in vitro model was developed to explore cytokines for synovial MSC mobilization, with PDGF-BB identified as the most effective. Intra-articular injection of PDGF-BB led to increased MSC numbers in synovial fluid in rats.
STEM CELL REVIEWS AND REPORTS
(2021)
Article
Cell & Tissue Engineering
Naoto Watanabe, Kentaro Endo, Keiichiro Komori, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Yuji Kohno, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya
STEM CELL REVIEWS AND REPORTS
(2020)
Article
Veterinary Sciences
Kentaro Endo, Naoki Fujita, Takayuki Nakagawa, Ryohei Nishimura
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2019)
Article
Veterinary Sciences
Eunryel Nam, Naoki Fujita, Maresuke Morita, Hsing-Yi Lin, Kentaro Endo, Takayuki Nakagawa, Ryohei Nishimura, Keiko Tsuzuki
JAPANESE JOURNAL OF VETERINARY RESEARCH
(2018)