Cellular and molecular pathways of structural damage in rheumatoid arthritis

Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis

(2016) Somaiya Mateen et al.   CLINICA CHIMICA ACTA

Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation

(2016) MM Matzelle et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis

(2016) Nida Meednu et al.   Arthritis & Rheumatology

Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis

(2015) Kyoung-Woon Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

(2015) Lynett Danks et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts

(2015) Rebecca Baum et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Update on autoantibodies to modified proteins

(2015) René E.M. Toes et al.   CURRENT OPINION IN RHEUMATOLOGY

Immunopathology of synovitis: from histology to molecular pathways

(2015) Marleen G. van de Sande et al.   RHEUMATOLOGY

Fibroblasten als pathogene Zellen in der rheumatischen Entzündung

(2015) C. Schönfeld et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

Brief Report: Tumor Necrosis Factor and Interleukin-6 Differentially Regulate Dkk-1 in the Inflamed Arthritic Joint

(2015) Nataliya Yeremenko et al.   Arthritis & Rheumatology

Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases

(2015) Dulshara Sachini Amarasekara et al.   Journal of Immunology Research

Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss

(2015) Tania N. Crotti et al.   Journal of Immunology Research

Cellular and molecular mechanisms of cartilage damage and repair

(2014) Joanna C. Sherwood et al.   DRUG DISCOVERY TODAY

The pathogenic potential of autoreactive antibodies in rheumatoid arthritis

(2014) Marieke Bax et al.   Seminars in Immunopathology

Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies

(2013) Arnd Kleyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

(2013) Yoann Rombouts et al.   ANNALS OF THE RHEUMATIC DISEASES

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory monocytes and Fc  receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

(2013) M. Seeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

(2012) Diederik P C de Rooy et al.   ANNALS OF THE RHEUMATIC DISEASES

Moonlighting osteoclasts as undertakers of apoptotic cells

(2012) Ulrike Harre et al.   AUTOIMMUNITY

Citrullination under physiological and pathological conditions

(2012) Zsuzsanna Baka et al.   JOINT BONE SPINE

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

The role of sialic acid as a modulator of the anti-inflammatory activity of IgG

(2012) Sybille Böhm et al.   Seminars in Immunopathology

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

(2012) Christopher A. Nelson et al.   STRUCTURE

Epigenetic contributions in the development of rheumatoid arthritis

(2012) Kerstin Klein et al.   ARTHRITIS RESEARCH & THERAPY

The osteoclast and its unique cytoskeleton

(2011) Steven L. Teitelbaum   Annals of the New York Academy of Sciences

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

(2011) L. Yeo et al.   ANNALS OF THE RHEUMATIC DISEASES

Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis

(2011) P. Suwannalai et al.   ARTHRITIS AND RHEUMATISM

IL-1  and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

(2011) T. Mori et al.   INTERNATIONAL IMMUNOLOGY

Circulating Dickkopf-1 Is Correlated with Bone Erosion and Inflammation in Rheumatoid Arthritis

(2011) SHI-YAO WANG et al.   JOURNAL OF RHEUMATOLOGY

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

(2011) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

(2011) Heidi Kokkonen et al.   ARTHRITIS RESEARCH & THERAPY

Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis

(2011) Tobias Braun et al.   ARTHRITIS RESEARCH & THERAPY

Baseline RANKL:OPG ratio and markers of bone and cartilage degradation predict annual radiological progression over 11 years in rheumatoid arthritis

(2010) L. H. D. van Tuyl et al.   ANNALS OF THE RHEUMATIC DISEASES

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor α production

(2010) Ming-Chi Lu et al.   ARTHRITIS AND RHEUMATISM

Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid

(2010) Hans U. Scherer et al.   ARTHRITIS AND RHEUMATISM

IL-17A suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via IL-17RA or IL-17RC receptors in RAW264.7 cells

(2010) Satoshi Kitami et al.   BIOCHIMIE

Cellular communications in bone homeostasis and repair

(2010) Ken-ichi Nakahama   CELLULAR AND MOLECULAR LIFE SCIENCES

Interleukin-1β is a potent inhibitor of bone formation in vitro

(2010) Philip Stashenko et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

(2010) Shigeru Kotake et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Rheumatoid arthritis progression mediated by activated synovial fibroblasts

(2010) Elena Neumann et al.   TRENDS IN MOLECULAR MEDICINE

Denosumab-mediated increase in hand bone mineral density associated with decreased progression of bone erosion in rheumatoid arthritis patients

(2010) A. Deodhar et al.   ARTHRITIS CARE & RESEARCH

Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins

(2010) Katleen Van Steendam et al.   ARTHRITIS RESEARCH & THERAPY

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Bone remodeling in rheumatic disease: a question of balance

(2009) Nicole C. Walsh et al.   IMMUNOLOGICAL REVIEWS

Osteoblast Function Is Compromised at Sites of Focal Bone Erosion in Inflammatory Arthritis

(2009) Nicole C Walsh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Invadosomes at a glance

(2009) S. Linder   JOURNAL OF CELL SCIENCE

Anakinra for Rheumatoid Arthritis: A Systematic Review

(2009) M. MERTENS et al.   JOURNAL OF RHEUMATOLOGY

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

(2008) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis–specific autoantibodies to citrullinated proteins complexed with fibrinogen

(2008) Cyril Clavel et al.   ARTHRITIS AND RHEUMATISM

IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-  and IL-17

(2008) M. Hashizume et al.   RHEUMATOLOGY