Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis

Inhibition of T cell-dependent and RANKL-dependent osteoclastogenic processes associated with high levels of bone mass in interleukin-15 receptor-deficient mice

(2010) Souad Djaafar et al.   ARTHRITIS AND RHEUMATISM

Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes

(2010) Se Hwan Mun et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Radiographic study on the pattern of wrist joint destruction in rheumatoid arthritis

(2010) Takashi Kitamura et al.   CLINICAL RHEUMATOLOGY

Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis

(2010) Benoit Le Goff et al.   JOINT BONE SPINE

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells

(2010) Jochen Schulze et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium

(2010) A. J. Hueber et al.   JOURNAL OF IMMUNOLOGY

Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis

(2010) Marc Baud'Huin et al.   JOURNAL OF PATHOLOGY

Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis

(2010) M. Güler-Yüksel et al.   OSTEOARTHRITIS AND CARTILAGE

Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis

(2010) K. Soderstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

Osteoporosis in Ankylosing Spondylitis

(2010) Marina Magrey et al.   Current Rheumatology Reports

A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner

(2009) Leonard Rifas et al.   ARTHRITIS AND RHEUMATISM

Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo

(2009) Roland Axmann et al.   ARTHRITIS AND RHEUMATISM

Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis

(2009) Gaby Palmer et al.   ARTHRITIS AND RHEUMATISM

Prevention of glucocorticoid-induced bone loss in mice by inhibition of RANKL

(2009) Lorenz C. Hofbauer et al.   ARTHRITIS AND RHEUMATISM

M-CSF elevates c-Fos and phospho-C/EBP (S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification

(2009) G. D. Jack et al.   BLOOD

Control of RANKL gene expression

(2009) Charles A. O'Brien   BONE

Colony-Stimulating Factor-1 (CSF-1) Directly Inhibits Receptor Activator of Nuclear Factor-κB Ligand (RANKL) Expression by Osteoblasts

(2009) Y. Wittrant et al.   ENDOCRINOLOGY

Transcriptional regulation of bone and joint remodeling by NFAT

(2009) Despina Sitara et al.   IMMUNOLOGICAL REVIEWS

IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-α antibody: A novel mechanism of osteoclastogenesis by IL-17

(2009) Toru Yago et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Osteoimmunology: Crosstalk Between the Immune and Bone Systems

(2009) Tomoki Nakashima et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The  -Isoform of p38 MAPK Specifically Regulates Arthritic Bone Loss

(2009) C. Bohm et al.   JOURNAL OF IMMUNOLOGY

RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies

(2009) Marina Stolina et al.   ARTHRITIS RESEARCH & THERAPY

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

(2008) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals

(2008) Masahiro Shinohara et al.   CELL

Interleukin-6 Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclastogenesis by Diverting Cells into the Macrophage Lineage: Key Role of Serine727Phosphorylation of Signal Transducer and Activator of Transcription 3

(2008) Laurence Duplomb et al.   ENDOCRINOLOGY

Interleukin-6 Directly Inhibits Osteoclast Differentiation by Suppressing Receptor Activator of NF-κB Signaling Pathways

(2008) Fumio Yoshitake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

The IL-33/ST2 pathway: therapeutic target and novel biomarker

(2008) Rahul Kakkar et al.   NATURE REVIEWS DRUG DISCOVERY

IL-33 exacerbates antigen-induced arthritis by activating mast cells

(2008) D. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE

TNF-mediated inflammatory disease

(2007) JR Bradley   JOURNAL OF PATHOLOGY