Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease

In This Issue

(2015)   CELL

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

(2015) Corina E. Antal et al.   Cell Reports

Intramolecular Conformational Changes Optimize Protein Kinase C Signaling

(2014) Corina E. Antal et al.   CHEMISTRY & BIOLOGY

Synapto-depressive effects of amyloid beta require PICK1

(2014) Stephanie Alfonso et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain

(2014) Kazuhiko Tagawa et al.   HUMAN MOLECULAR GENETICS

Alzheimer disease and cancer risk: a meta-analysis

(2014) Hai-bin Shi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

(2014) Catherine Chen et al.   MOLECULAR CELL

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

(2013) Carlos Cruchaga et al.   NATURE

Function and Dysfunction of Presenilin

(2013) Jie Shen   Neurodegenerative Diseases

Metabotropic NMDA receptor function is required for  -amyloid-induced synaptic depression

(2013) H. W. Kessels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Alzheimer Disease in 2020

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

GEMINI: Integrative Exploration of Genetic Variation and Genome Annotations

(2013) Umadevi Paila et al.   PLoS Computational Biology

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

(2011) Kyle C. Wilcox et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Protein Kinase Cα Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs Large Homolog 1 (DLG1)

(2011) Audrey K. O'Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1

(2011) Rachel F Lane et al.   Molecular Neurodegeneration

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

(2010) S. W. Pimplikar et al.   JOURNAL OF NEUROSCIENCE

Interaction with AKAP79 Modifies the Cellular Pharmacology of PKC

(2010) Naoto Hoshi et al.   MOLECULAR CELL

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protein kinase C: poised to signal

(2009) Alexandra C. Newton   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

(2009) Jürgen Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

PKC  mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling

(2008) D. S. Verbeek et al.   JOURNAL OF CELL SCIENCE

Enhanced generation of Alzheimer’s amyloid-β following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C

(2008) Odete A. B. da Cruz e Silva et al.   JOURNAL OF NEUROCHEMISTRY