The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5′ splice site that impacts splicing regulation in Q157R patients

Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals

(2017) Marco Preußner et al.   MOLECULAR CELL

Pathogenic variants that alter protein code often disrupt splicing

(2017) Rachel Soemedi et al.   NATURE GENETICS

Identification of pathogenic gene mutations inLMNAandMYBPC3that alter RNA splicing

(2017) Kaoru Ito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

(2016) C. Pabst et al.   BLOOD

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis

(2016) Daichi Inoue et al.   GENES & DEVELOPMENT

U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3′ End Formation

(2016) Sung Mi Park et al.   MOLECULAR CELL

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators

(2016) Jinsong Qiu et al.   RNA

Sec16 alternative splicing dynamically controls COPII transport efficiency

(2016) Ilka Wilhelmi et al.   Nature Communications

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

(2015) Cara Lunn Shirai et al.   CANCER CELL

A novel 3′ splice site recognition by the two zinc fingers in the U2AF small subunit

(2015) Hisashi Yoshida et al.   GENES & DEVELOPMENT

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

(2015) Tiffany Y.-T. Hsu et al.   NATURE

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

(2015) Cheryl M. Koh et al.   NATURE

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

(2015) Vincent-Philippe Lavallée et al.   NATURE GENETICS

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Genomic functions of U2AF in constitutive and regulated splicing

(2015) Tongbin Wu et al.   RNA Biology

Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

(2014) Christopher N. Hahn et al.   IMMUNOLOGICAL REVIEWS

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing

(2014) T Okeyo-Owuor et al.   LEUKEMIA

Rhythmic U2af26 Alternative Splicing Controls PERIOD1 Stability and the Circadian Clock in Mice

(2014) Marco Preußner et al.   MOLECULAR CELL

Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome

(2014) Changwei Shao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms

(2013) B. Przychodzen et al.   BLOOD

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data

(2011) H. Li   BIOINFORMATICS

RNA sequencing reveals two major classes of gene expression levels in metazoan cells

(2011) D. Hebenstreit et al.   Molecular Systems Biology

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

(2011) Timothy A Graubert et al.   NATURE GENETICS

Analysis and design of RNA sequencing experiments for identifying isoform regulation

(2010) Yarden Katz et al.   NATURE METHODS

TogoWS: integrated SOAP and REST APIs for interoperable bioinformatics Web services

(2010) T. Katayama et al.   NUCLEIC ACIDS RESEARCH

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice

(2008) Dong Wang et al.   BMC GENOMICS