Linear-No-Threshold Default Assumptions are Unwarranted for Cytotoxic Endpoints Independently Triggered by Ultrasensitive Molecular Switches

Bogen's Critique of Linear-No-Threshold Default Assumptions

(2016) Kenny S. Crump   RISK ANALYSIS

Thresholds and ultrasensitivity from negative cooperativity

(2016) S. H. Ha et al.   SCIENCE

Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis

(2016) Vivek Raj Senthivel et al.   Scientific Reports

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma

(2015) Haizheng Hong et al.   MARINE POLLUTION BULLETIN

Linear-No-Threshold Default Assumptions for Noncancer and Nongenotoxic Cancer Risks: A Mathematical and Biological Critique

(2015) Kenneth T. Bogen   RISK ANALYSIS

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

(2015) Sharadha Dayalan Naidu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos

(2014) Cheng Zeng et al.   AQUATIC TOXICOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

The Cdk1–APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch

(2013) Qiong Yang et al.   NATURE CELL BIOLOGY

Influence of infection during pregnancy on fetal development

(2013) Kristina M Adams Waldorf et al.   REPRODUCTION

Ultrasensitive response motifs: basic amplifiers in molecular signalling networks

(2013) Q. Zhang et al.   Open Biology

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation

(2012) Barbara Szomolay et al.   BMC Systems Biology

Profiling Environmental Chemicals for Activity in the Antioxidant Response Element Signaling Pathway Using a High Throughput Screening Approach

(2012) Sunita J Shukla et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia

(2012) Kenneth T. Bogen   MEDICAL HYPOTHESES

Cadmium-induced teratogenicity: Association with ROS-mediated endoplasmic reticulum stress in placenta

(2012) Zhen Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of survival gene hsp70

(2011) Jordan Thomas Silver et al.   CELL STRESS & CHAPERONES

Use of threshold and mode of action in risk assessment

(2011) Kenny S. Crump   CRITICAL REVIEWS IN TOXICOLOGY

Quantitative analysis of transient and sustained transforming growth factor-  signaling dynamics

(2011) Z. Zi et al.   Molecular Systems Biology

Robust Network Topologies for Generating Switch-Like Cellular Responses

(2011) Najaf A. Shah et al.   PLoS Computational Biology

Thiol-Based Redox Switches and Gene Regulation

(2010) Haike Antelmann et al.   ANTIOXIDANTS & REDOX SIGNALING

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Protein Folding in the Cytoplasm and the Heat Shock Response

(2010) R. M. Vabulas et al.   Cold Spring Harbor Perspectives in Biology

Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development

(2010) G Wang et al.   Cell Death & Disease

Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention

(2009) M. C.-J. Cheeran et al.   CLINICAL MICROBIOLOGY REVIEWS

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues

(2009) A. Lipshtat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systems biology perspective on Nrf2-mediated antioxidant response

(2009) Qiang Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

In vivo analysis of heat-shock-protein-70 induction following pulsed laser irradiation in a transgenic reporter mouse

(2008) Caitlin E. O’Connell-Rodwell et al.   JOURNAL OF BIOMEDICAL OPTICS

Heat shock proteins: essential proteins for apoptosis regulation

(2008) D. Lanneau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE