Mechanisms of HIV persistence in HIV reservoirs

HIV-1 Alters Intestinal Expression of Drug Transporters and Metabolic Enzymes: Implications for Antiretroviral Drug Disposition

(2016) Olena Kis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HIV-1 Reservoirs During Suppressive Therapy

(2016) Kirston Barton et al.   TRENDS IN MICROBIOLOGY

Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine

(2015) Maria Blasi et al.   AIDS

Healthy HIV-1-Infected Individuals on Highly Active Antiretroviral Therapy Harbor HIV-1 in Their Alveolar Macrophages

(2015) Sushma K. Cribbs et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The Role of Human Dendritic Cells in HIV-1 Infection

(2015) Zahra Ahmed et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Detection of Simian Immunodeficiency Virus in Semen, Urethra, and Male Reproductive Organs during Efficient Highly Active Antiretroviral Therapy

(2015) G. Matusali et al.   JOURNAL OF VIROLOGY

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

CD4 mimetics sensitize HIV-1-infected cells to ADCC

(2015) Jonathan Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

(2015) Meghan K. Rothenberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: results of a randomized phase II exploratory clinical trial

(2015) Fabrizio Ensoli et al.   Retrovirology

Towards an HIV-1 cure: measuring the latent reservoir

(2015) Katherine M. Bruner et al.   TRENDS IN MICROBIOLOGY

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

(2015) Christa Buckheit Sturdevant et al.   PLoS Pathogens

Compartmentalization, Viral Evolution, and Viral Latency of HIV in the CNS

(2015) Maria M. Bednar et al.   Current HIV/AIDS Reports

HIV-1 Infection: The Role of the Gastrointestinal Tract

(2014) Mariangela Cavarelli et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation

(2014) Timothy J. Henrich et al.   ANNALS OF INTERNAL MEDICINE

Gastrointestinal Tract and the Mucosal Macrophage Reservoir in HIV Infection

(2014) Dallas Brown et al.   Clinical and Vaccine Immunology

Humanized mouse models for HIV-1 infection of the CNS

(2014) Jenna B. Honeycutt et al.   JOURNAL OF NEUROVIROLOGY

Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients

(2014) A Kök et al.   Mucosal Immunology

Small alveolar macrophages are infected preferentially by HIV and exhibit impaired phagocytic function

(2014) K C Jambo et al.   Mucosal Immunology

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathogenesis of HIV-associated neurocognitive disorders

(2014) Maria F. Chen et al.   Current Opinion in HIV and AIDS

Universal Tre (uTre) recombinase specifically targets the majority of HIV-1 isolates

(2014) Janet Karpinski et al.   Journal of the International AIDS Society

Highly Active Antiretroviral Therapies Are Effective against HIV-1 Cell-to-Cell Transmission

(2014) Luis M. Agosto et al.   PLoS Pathogens

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

(2014) Paul W. Denton et al.   PLoS Pathogens

HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

(2014) Nuria Izquierdo-Useros et al.   PLoS Pathogens

Understanding HIV Compartments and Reservoirs

(2014) Valentina Svicher et al.   Current HIV/AIDS Reports

High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacy

(2013) Christopher J.A. Duncan et al.   AIDS

Analysis of HIV Quasispecies Suggests Compartmentalization in the Liver

(2013) Patricia K. Penton et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes

(2013) Xiaoyu Pan et al.   CELL RESEARCH

Quasispecies tropism and compartmentalization in gut and peripheral blood during early and chronic phases of HIV-1 infection: possible correlation with immune activation markers

(2013) G. Rozera et al.   CLINICAL MICROBIOLOGY AND INFECTION

An Example of Genetically Distinct HIV Type 1 Variants in Cerebrospinal Fluid and Plasma During Suppressive Therapy

(2013) Viktor Dahl et al.   JOURNAL OF INFECTIOUS DISEASES

CD133+ Hematopoietic Progenitor Cells Harbor HIV Genomes in a Subset of Optimally Treated People With Long-Term Viral Suppression

(2013) L. A. McNamara et al.   JOURNAL OF INFECTIOUS DISEASES

The Kidney as a Reservoir for HIV-1 after Renal Transplantation

(2013) G. Canaud et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

(2013) Christine Katlama et al.   LANCET

The search for an HIV cure: tackling latent infection

(2013) Stephen J Kent et al.   LANCET INFECTIOUS DISEASES

Molecular and pathologic insights from latent HIV-1 infection in the human brain

(2013) P. Desplats et al.   NEUROLOGY

Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant

(2013) Deborah Persaud et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV-1 Nef Sequence and Functional Compartmentalization in the Gut Is Not Due to Differential Cytotoxic T Lymphocyte Selective Pressure

(2013) Martha J. Lewis et al.   PLoS One

Cell-associated HIV RNA: a dynamic biomarker of viral persistence

(2013) Alexander O Pasternak et al.   Retrovirology

The HIV-1-containing macrophage compartment: a perfect cellular niche?

(2013) Joshua Tan et al.   TRENDS IN MICROBIOLOGY

How to best measure HIV reservoirs?

(2013) Christine Rouzioux et al.   Current Opinion in HIV and AIDS

Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

(2013) Susanne Eriksson et al.   PLoS Pathogens

Highly active antiretroviral therapy does not completely suppress HIV in semen of sexually active HIV-infected men who have sex with men

(2012) Joseph A. Politch et al.   AIDS

Low Cerebrospinal Fluid Concentrations of the Nucleotide HIV Reverse Transcriptase Inhibitor, Tenofovir

(2012) Brookie M. Best et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HIV-1 DNA Is Detected in Bone Marrow Populations Containing CD4+ T Cells but Is not Found in Purified CD34+ Hematopoietic Progenitor Cells in Most Patients on Antiretroviral Therapy

(2012) Christine M. Durand et al.   JOURNAL OF INFECTIOUS DISEASES

Hematopoietic Precursor Cells Isolated From Patients on Long-term Suppressive HIV Therapy Did Not Contain HIV-1 DNA

(2012) Lina Josefsson et al.   JOURNAL OF INFECTIOUS DISEASES

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF- B Activation

(2012) L. A. McNamara et al.   JOURNAL OF VIROLOGY

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Excision of HIV-1 Proviral DNA by Recombinant Cell Permeable Tre-Recombinase

(2012) Lakshmikanth Mariyanna et al.   PLoS One

Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection

(2012) N. M. Archin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-level HIV infection of hepatocytes

(2012) Ling Kong et al.   Virology Journal

Absence of HIV-1 Evolution in the Gut-Associated Lymphoid Tissue from Patients on Combination Antiviral Therapy Initiated during Primary Infection

(2012) Teresa H. Evering et al.   PLoS Pathogens

Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy

(2011) Duncan Chege et al.   AIDS

HIV Variability in the Liver and Evidence of Possible Compartmentalization

(2011) Jason T. Blackard et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Brain Cell Reservoirs of Latent Virus in Presymptomatic HIV-Infected Individuals

(2011) Katherine A. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract

(2011) Laura J Else et al.   ANTIVIRAL THERAPY

Valganciclovir Reduces T Cell Activation in HIV-Infected Individuals With Incomplete CD4+ T Cell Recovery on Antiretroviral Therapy

(2011) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Lack of Compartmentalization of HIV-1 Quasispecies Between the Gut and Peripheral Blood Compartments

(2011) Hiromi Imamichi et al.   JOURNAL OF INFECTIOUS DISEASES

Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism

(2011) E. A. Eugenin et al.   JOURNAL OF NEUROSCIENCE

The association of HIV viral load with indirect markers of liver injury

(2011) J. E. Forrester et al.   JOURNAL OF VIRAL HEPATITIS

The Gut Mucosal Viral Reservoir in HIV-Infected Patients Is Not the Major Source of Rebound Plasma Viremia following Interruption of Highly Active Antiretroviral Therapy

(2011) P. Lerner et al.   JOURNAL OF VIROLOGY

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

(2011) Alex Sigal et al.   NATURE

Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro

(2011) Vanessa A Evans et al.   Retrovirology

Tissue Says Blood Is Misleading, Confusing HIV Cure Efforts

(2011) J. Cohen   SCIENCE

Lymph nodes harbor viral reservoirs that cause rebound of plasma viremia in SIV-infected macaques upon cessation of combined antiretroviral therapy

(2011) Mariko Horiike et al.   VIROLOGY

Eradication of HIV from the brain: reasons for pause

(2010) Avindra Nath et al.   AIDS

Effects of central nervous system antiretroviral penetration on cognitive functioning in the ALLRT cohort

(2010) Marlene Smurzynski et al.   AIDS

Evidence for Adaptive Evolution at the Divergence Between Lymphoid and Brain HIV-1 nef Genes

(2010) Kevin C. Olivieri et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1 proviral DNA copy number in peripheral blood leucocytes and bronchoalveolar lavage cells of AIDS patients

(2010) J. R. CLARKE et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Discordance Between Cerebral Spinal Fluid and Plasma HIV Replication in Patients with Neurological Symptoms Who Are Receiving Suppressive Antiretroviral Therapy

(2010) Ana Canestri et al.   CLINICAL INFECTIOUS DISEASES

Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: Implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis

(2010) Ana C. Tuyama et al.   HEPATOLOGY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

(2010) Christoph C Carter et al.   NATURE MEDICINE

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

CD4+ T Cell Depletion, Immune Activation and Increased Production of Regulatory T Cells in the Thymus of HIV-Infected Individuals

(2010) Alessandra Bandera et al.   PLoS One

Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton

(2010) P. U. Cameron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiretroviral drug concentrations in the male and female genital tract: implications for the sexual transmission of HIV

(2010) Stephen Taylor et al.   Current Opinion in HIV and AIDS

Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescents

(2009) Kunjal Patel et al.   AIDS

HIV integration site distributions in resting and activated CD4+ T cells infected in culture

(2009) Troy Brady et al.   AIDS

The transport of anti-HIV drugs across blood–CNS interfaces: Summary of current knowledge and recommendations for further research

(2009) Lavanya Varatharajan et al.   ANTIVIRAL RESEARCH

gp120 modulates the biology of human hepatic stellate cells: a link between HIV infection and liver fibrogenesis

(2009) R. Bruno et al.   GUT

No Evidence for Decay of the Latent Reservoir in HIV‐1–Infected Patients Receiving Intensive Enfuvirtide‐Containing Antiretroviral Therapy

(2009) Rajesh T. Gandhi et al.   JOURNAL OF INFECTIOUS DISEASES

Monotypic Human Immunodeficiency Virus Type 1 Genotypes across the Uterine Cervix and in Blood Suggest Proliferation of Cells with Provirus

(2009) M. E. Bull et al.   JOURNAL OF VIROLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Evidence for Limited Genetic Compartmentalization of HIV-1 between Lung and Blood

(2009) Laura Heath et al.   PLoS One

Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

(2009) J. B. Dinoso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Characterization of a CD4-independent clinical HIV-1 that can efficiently infect human hepatocytes through chemokine (C-X-C motif) receptor 4

(2008) Peng Xiao et al.   AIDS

Low atazanavir concentrations in cerebrospinal fluid

(2008) Brookie M Best et al.   AIDS

Male Genital Tract Compartmentalization of Human Immunodeficiency Virus Type 1 (HIV)

(2008) Kurt Diem et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Emerging Concepts in the Immunopathogenesis of AIDS

(2008) Daniel C. Douek et al.   Annual Review of Medicine

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

(2008) A. Bosque et al.   BLOOD

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of the Follicular Dendritic Cell Reservoir of Human Immunodeficiency Virus Type 1

(2008) B. F. Keele et al.   JOURNAL OF VIROLOGY

HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination

(2008) Aikaterini Alexaki et al.   PLoS Pathogens

Effect of Highly Active Antiretroviral Therapy on Viral Burden in the Lungs of HIV‐Infected Subjects

(2007) Homer L. Twigg III et al.   JOURNAL OF INFECTIOUS DISEASES

The genital tract immune milieu: an important determinant of HIV susceptibility and secondary transmission

(2007) R. Kaul et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY