Toll-like receptor signaling and stages of addiction

Risky choice and brain CRF after adolescent ethanol vapor exposure and social stress in adulthood

(2016) Nathalie Boutros et al.   BEHAVIOURAL BRAIN RESEARCH

Circulating tumour necrosis factor is highly correlated with brainstem serotonin transporter availability in humans

(2016) Rajeev Krishnadas et al.   BRAIN BEHAVIOR AND IMMUNITY

Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence

(2016) Jorge Montesinos et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-1 receptor signaling in the basolateral amygdala modulates binge-like ethanol consumption in male C57BL/6J mice

(2016) S. Alex Marshall et al.   BRAIN BEHAVIOR AND IMMUNITY

A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood

(2016) Amul J. Sakharkar et al.   Brain Structure & Function

Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?

(2016) Sinéad M. Ryan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neurobiologic Advances from the Brain Disease Model of Addiction

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

All Roads Lead to the miRNome: miRNAs Have a Central Role in the Molecular Pathophysiology of Psychiatric Disorders

(2016) Richard M. O’Connor et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Brain pathways to recovery from alcohol dependence

(2015) Changhai Cui et al.   ALCOHOL

Chronic Intracerebroventricular Infusion of Monocyte Chemoattractant Protein-1 Leads to a Persistent Increase in Sweetened Ethanol Consumption During Operant Self-Administration But Does Not Influence Sucrose Consumption in Long-Evans Rats

(2015) John P. Valenta et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus

(2015) Mary-Louise Risher et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain

(2015) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming

(2015) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Adolescent Intermittent Ethanol Exposure Is Associated with Increased Risky Choice and Decreased Dopaminergic and Cholinergic Neuron Markers in Adult Rats

(2015) Nathalie Boutros et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages

(2015) Banishree Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

(2015) M. D. Weber et al.   JOURNAL OF NEUROSCIENCE

DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling

(2015) A L Northcutt et al.   MOLECULAR PSYCHIATRY

Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood

(2015) Subhash C. Pandey et al.   NEUROBIOLOGY OF DISEASE

Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2

(2015) María Pascual et al.   NEUROPHARMACOLOGY

CRF-Amplified Neuronal TLR4/MCP-1 Signaling Regulates Alcohol Self-Administration

(2015) Harry L June et al.   NEUROPSYCHOPHARMACOLOGY

Mechanisms of neuroimmune gene induction in alcoholism

(2015) Fulton T. Crews et al.   PSYCHOPHARMACOLOGY

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

(2015) Dora Brites et al.   Frontiers in Cellular Neuroscience

MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease

(2015) Sowmya V. Yelamanchili et al.   PLoS Pathogens

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning

(2015) Ryan P. Vetreno et al.   Frontiers in Neuroscience

Impulsive choice and anxiety-like behavior in adult rats exposed to chronic intermittent ethanol during adolescence and adulthood

(2014) Jana Mejia-Toiber et al.   BEHAVIOURAL BRAIN RESEARCH

Role of Inflammatory Pathways, Blood Mononuclear Cells, and Gut-Derived Bacterial Products in Alcohol Dependence

(2014) Sophie Leclercq et al.   BIOLOGICAL PSYCHIATRY

Peripheral Inflammation Acutely Impairs Human Spatial Memory via Actions on Medial Temporal Lobe Glucose Metabolism

(2014) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

A review of the relationship between proinflammatory cytokines and major depressive disorder

(2014) Juan Joseph Young et al.   JOURNAL OF AFFECTIVE DISORDERS

Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling

(2014) Jian Y. Zou et al.   PLoS One

Acute Binge Drinking Increases Serum Endotoxin and Bacterial DNA Levels in Healthy Individuals

(2014) Shashi Bala et al.   PLoS One

Adolescent, but Not Adult, Binge Ethanol Exposure Leads to Persistent Global Reductions of Choline Acetyltransferase Expressing Neurons in Brain

(2014) Ryan P. Vetreno et al.   PLoS One

Redox Modulation of HMGB1-Related Signaling

(2013) Christina Janko et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of Chronic Delivery of the Toll-like Receptor 4 Antagonist (+)-Naltrexone on Incubation of Heroin Craving

(2013) Florence R. Theberge et al.   BIOLOGICAL PSYCHIATRY

Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence

(2013) Yury O Nunez et al.   BMC GENOMICS

Neuroimmune signaling: a key component of alcohol abuse

(2013) Jody Mayfield et al.   CURRENT OPINION IN NEUROBIOLOGY

C-reactive protein and substance use disorders in adolescence and early adulthood: A prospective analysis

(2013) E. Jane Costello et al.   DRUG AND ALCOHOL DEPENDENCE

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

(2013) Liya Qin et al.   GLIA

Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

(2013) Dora Lippai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells

(2013) Sara Fernandez-Lizarbe et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNAs in the Brain: It's Regulatory Role in Neuroinflammation

(2013) Menaka C. Thounaojam et al.   MOLECULAR NEUROBIOLOGY

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking

(2013) Ryan P. Vetreno et al.   NEUROBIOLOGY OF DISEASE

Visceral Influences on Brain and Behavior

(2013) Hugo D. Critchley et al.   NEURON

Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility

(2013) Leon Garland Coleman et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Long-Term Effects of Chronic Intermittent Ethanol Exposure in Adolescent and Adult Rats: Radial-Arm Maze Performance and Operant Food Reinforced Responding

(2013) Mary-Louise Risher et al.   PLoS One

Chronic Alcohol-Induced microRNA-155 Contributes to Neuroinflammation in a TLR4-Dependent Manner in Mice

(2013) Dora Lippai et al.   PLoS One

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

H1 and HMGB1: modulators of chromatin structure

(2012) Jean O. Thomas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Stress-Induced Neuroinflammation: Role of the Toll-Like Receptor-4 Pathway

(2012) Iciar Gárate et al.   BIOLOGICAL PSYCHIATRY

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

(2012) Fulton T. Crews et al.   BIOLOGICAL PSYCHIATRY

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

(2012) Michael Maes et al.   BMC Medicine

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei

(2012) Kate Freeman et al.   Journal of Neuroinflammation

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and toll-like receptors in the adult prefrontal cortex

(2012) R.P. Vetreno et al.   NEUROSCIENCE

Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics

(2012) Yury O. Nunez et al.   Frontiers in Genetics

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

(2011) Yuri A. Blednov et al.   ADDICTION BIOLOGY

Up-Regulation of MicroRNAs in Brain of Human Alcoholics

(2011) Joanne M. Lewohl et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Adolescent Binge Drinking Alters Adult Brain Neurotransmitter Gene Expression, Behavior, Brain Regional Volumes, and Neurochemistry in Mice

(2011) Leon G. Coleman Jr et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Deficits in attentional control: Cholinergic mechanisms and circuitry-based treatment approaches.

(2011) Martin Sarter et al.   BEHAVIORAL NEUROSCIENCE

Minocycline reduces ethanol drinking

(2011) R.G. Agrawal et al.   BRAIN BEHAVIOR AND IMMUNITY

Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage

(2011) María Pascual et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice

(2011) Y.A. Blednov et al.   BRAIN BEHAVIOR AND IMMUNITY

Induction of innate immune genes in brain create the neurobiology of addiction

(2011) F.T. Crews et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1

(2011) M. Maroso et al.   JOURNAL OF INTERNAL MEDICINE

Binge alcohol drinking is associated with GABAA  2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the roles of microRNAs in drug addiction and neuroplasticity

(2011) Jean-Luc Dreyer   Genome Medicine

Associations Between Heavy Drinking and Changes in Impulsive Behavior Among Adolescent Boys

(2010) Helene R. White et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Induction of Innate Immune Gene Expression Cascades in Brain Slice Cultures by Ethanol: Key Role of NF-κB and Proinflammatory Cytokines

(2010) Jian Zou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Prospects for Minocycline Neuroprotection

(2010) Jennifer M. Plane et al.   ARCHIVES OF NEUROLOGY

Using glutamate homeostasis as a target for treating addictive disorders

(2010) Kathryn J. Reissner et al.   BEHAVIOURAL PHARMACOLOGY

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

(2010) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

(2010) E. Okun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder

(2009) Rushaniya A. Khairova et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

Neuro-inflammation induced in the hippocampus of ‘binge drinking’ rats may be mediated by elevated extracellular glutamate content

(2009) Roberta J. Ward et al.   JOURNAL OF NEUROCHEMISTRY

Nuclear Factor  B Signaling Regulates Neuronal Morphology and Cocaine Reward

(2009) S. J. Russo et al.   JOURNAL OF NEUROSCIENCE

Anti-RAGE and A  Immunoglobulin Levels Are Related to Dementia Level and Cognitive Performance

(2009) J. S. Wilson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

The blood–brain barrier and immune function and dysfunction

(2009) William A. Banks et al.   NEUROBIOLOGY OF DISEASE

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Impulsivity, frontal lobes and risk for addiction

(2009) Fulton Timm Crews et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inflammation and the Redox-sensitive AGE-RAGE Pathway as a Therapeutic Target in Alzheimer's Disease

(2008) Annette Maczurek et al.   Annals of the New York Academy of Sciences

Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment

(2008) Liya Qin et al.   Journal of Neuroinflammation

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Abstinence following Alcohol Drinking Produces Depression-Like Behavior and Reduced Hippocampal Neurogenesis in Mice

(2008) Jennie R Stevenson et al.   NEUROPSYCHOPHARMACOLOGY

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased MCP-1 and microglia in various regions of the human alcoholic brain

(2007) Jun He et al.   EXPERIMENTAL NEUROLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Induction of nuclear factor-κB in nucleus accumbens by chronic cocaine administration

(2003) Eugenius Ang et al.   JOURNAL OF NEUROCHEMISTRY