Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

A multiscale view of therapeutic protein aggregation: A colloid science perspective

(2015) Lucrèce Nicoud et al.   Biotechnology Journal

Advanced analyses of kinetic stabilities of iggs modified by mutations and glycosylation

(2015) Erik Sedlák et al.   PROTEIN SCIENCE

A multiscale view of therapeutic protein aggregation: A colloid science perspective

(2015) Lucrèce Nicoud et al.   Biotechnology Journal

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life

(2014) Ranajoy Majumdar et al.   mAbs

High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability

(2013) Rajoshi Chaudhuri et al.   AAPS Journal

Non-Arrhenius Protein Aggregation

(2013) Wei Wang et al.   AAPS Journal

Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody

(2013) Ranajoy Majumdar et al.   BIOCHEMISTRY

Immunogenicity of therapeutic proteins: Influence of aggregation

(2013) Kirsty D. Ratanji et al.   Journal of Immunotoxicology

Polyethyleneimine-based transient gene expression processes for suspension-adapted HEK-293E and CHO-DG44 cells

(2013) David L. Hacker et al.   PROTEIN EXPRESSION AND PURIFICATION

Transfer of engineered biophysical properties between different antibody formats and expression systems

(2012) J. V. Schaefer et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions: Part 1. Unfolding, Colloidal Interactions, and Formation of High-Molecular-Weight Aggregates

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of a Non-Arrhenius Model for Therapeutic Monoclonal Antibody Aggregation

(2011) Veysel Kayser et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Forced Degradation of Therapeutic Proteins

(2011) Andrea Hawe et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding

(2011) Veysel Kayser et al.   mAbs

High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies

(2011) Amy C. King et al.   PROTEIN SCIENCE

High throughput thermostability screening of monoclonal antibody formulations

(2009) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Between-Species Variation in the Kinetic Stability of TIM Proteins Linked to Solvation-Barrier Free Energies

(2008) Miguel Costas et al.   JOURNAL OF MOLECULAR BIOLOGY

Principles, approaches, and challenges for predicting protein aggregation rates and shelf life

(2008) William F. Weiss et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Extrinsic Fluorescent Dyes as Tools for Protein Characterization

(2008) Andrea Hawe et al.   PHARMACEUTICAL RESEARCH

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

(2007) Roxana M. Ionescu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES